Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9NPX

SARS-CoV-2 nsp1 bound to the Rhinolophus lepidus 40S ribosomal subunit (local refinement of the 40S body)

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0003735	molecular_function	structural constituent of ribosome
a	0005840	cellular_component	ribosome
a	0006412	biological_process	translation
A	0003723	molecular_function	RNA binding
A	0003735	molecular_function	structural constituent of ribosome
A	0005840	cellular_component	ribosome
A	0006412	biological_process	translation
A	0015935	cellular_component	small ribosomal subunit
A	0022627	cellular_component	cytosolic small ribosomal subunit
A	1990904	cellular_component	ribonucleoprotein complex
B	0003723	molecular_function	RNA binding
B	0003735	molecular_function	structural constituent of ribosome
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0005743	cellular_component	mitochondrial inner membrane
B	0005819	cellular_component	spindle
B	0006412	biological_process	translation
B	0015935	cellular_component	small ribosomal subunit
B	0022626	cellular_component	cytosolic ribosome
B	0022627	cellular_component	cytosolic small ribosomal subunit
B	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B	2001235	biological_process	positive regulation of apoptotic signaling pathway
C	0003735	molecular_function	structural constituent of ribosome
C	0005634	cellular_component	nucleus
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005840	cellular_component	ribosome
C	0006412	biological_process	translation
C	0022627	cellular_component	cytosolic small ribosomal subunit
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0019843	molecular_function	rRNA binding
D	0022627	cellular_component	cytosolic small ribosomal subunit
e	0003735	molecular_function	structural constituent of ribosome
e	0005829	cellular_component	cytosol
e	0005840	cellular_component	ribosome
e	0006412	biological_process	translation
e	0022627	cellular_component	cytosolic small ribosomal subunit
f	0003735	molecular_function	structural constituent of ribosome
f	0005840	cellular_component	ribosome
f	0006412	biological_process	translation
F	0003735	molecular_function	structural constituent of ribosome
F	0005840	cellular_component	ribosome
F	0006412	biological_process	translation
G	0003735	molecular_function	structural constituent of ribosome
G	0005840	cellular_component	ribosome
G	0006364	biological_process	rRNA processing
G	0006412	biological_process	translation
G	0022627	cellular_component	cytosolic small ribosomal subunit
G	0030686	cellular_component	90S preribosome
G	0032040	cellular_component	small-subunit processome
G	0042274	biological_process	ribosomal small subunit biogenesis
h	0000028	biological_process	ribosomal small subunit assembly
h	0003735	molecular_function	structural constituent of ribosome
h	0005055	molecular_function	laminin receptor activity
h	0005634	cellular_component	nucleus
h	0005737	cellular_component	cytoplasm
h	0005840	cellular_component	ribosome
h	0005886	cellular_component	plasma membrane
h	0006412	biological_process	translation
h	0007155	biological_process	cell adhesion
h	0015935	cellular_component	small ribosomal subunit
h	0022627	cellular_component	cytosolic small ribosomal subunit
h	0043236	molecular_function	laminin binding
H	0003735	molecular_function	structural constituent of ribosome
H	0005737	cellular_component	cytoplasm
H	0005840	cellular_component	ribosome
H	0006412	biological_process	translation
H	0022626	cellular_component	cytosolic ribosome
I	0003723	molecular_function	RNA binding
I	0003735	molecular_function	structural constituent of ribosome
I	0005730	cellular_component	nucleolus
I	0005737	cellular_component	cytoplasm
I	0006412	biological_process	translation
I	0015935	cellular_component	small ribosomal subunit
I	0019843	molecular_function	rRNA binding
I	0022627	cellular_component	cytosolic small ribosomal subunit
I	0042274	biological_process	ribosomal small subunit biogenesis
k	0003723	molecular_function	RNA binding
k	0003743	molecular_function	translation initiation factor activity
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005737	cellular_component	cytoplasm
k	0006413	biological_process	translational initiation
k	0006446	biological_process	regulation of translational initiation
k	0008135	molecular_function	translation factor activity, RNA binding
k	0010468	biological_process	regulation of gene expression
k	0016282	cellular_component	eukaryotic 43S preinitiation complex
k	0033290	cellular_component	eukaryotic 48S preinitiation complex
k	0043024	molecular_function	ribosomal small subunit binding
k	0043614	cellular_component	multi-eIF complex
K	0003735	molecular_function	structural constituent of ribosome
K	0005737	cellular_component	cytoplasm
K	0005840	cellular_component	ribosome
K	0006412	biological_process	translation
K	0022626	cellular_component	cytosolic ribosome
K	0022627	cellular_component	cytosolic small ribosomal subunit
M	0003735	molecular_function	structural constituent of ribosome
M	0005730	cellular_component	nucleolus
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
M	0022627	cellular_component	cytosolic small ribosomal subunit
M	0070181	molecular_function	small ribosomal subunit rRNA binding
N	0003735	molecular_function	structural constituent of ribosome
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0022627	cellular_component	cytosolic small ribosomal subunit
P	0003735	molecular_function	structural constituent of ribosome
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
R	0003735	molecular_function	structural constituent of ribosome
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	0022626	cellular_component	cytosolic ribosome
V	0003735	molecular_function	structural constituent of ribosome
V	0005791	cellular_component	rough endoplasmic reticulum
V	0005829	cellular_component	cytosol
V	0005840	cellular_component	ribosome
V	0006412	biological_process	translation
V	0022626	cellular_component	cytosolic ribosome
W	0003735	molecular_function	structural constituent of ribosome
W	0005791	cellular_component	rough endoplasmic reticulum
W	0005840	cellular_component	ribosome
W	0006412	biological_process	translation
W	0015935	cellular_component	small ribosomal subunit
W	0022626	cellular_component	cytosolic ribosome
X	0003735	molecular_function	structural constituent of ribosome
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	0022627	cellular_component	cytosolic small ribosomal subunit
Z	0003729	molecular_function	mRNA binding
Z	0003735	molecular_function	structural constituent of ribosome
Z	0005840	cellular_component	ribosome
Z	0006412	biological_process	translation
Z	0022626	cellular_component	cytosolic ribosome
Z	0022627	cellular_component	cytosolic small ribosomal subunit

Functional Information from PROSITE/UniProt

site_id	PS00053
Number of Residues	18
Details	RIBOSOMAL_S8 Ribosomal protein S8 signature. GfiVLTTSaGIMdheeAR

Chain	Residue	Details
P	GLY100-ARG117

site_id	PS00054
Number of Residues	23
Details	RIBOSOMAL_S11 Ribosomal protein S11 signature. LrALarS.GMkIgrieDvTPiPSD

Chain	Residue	Details
N	LEU116-IAS138

site_id	PS00055
Number of Residues	8
Details	RIBOSOMAL_S12 Ribosomal protein S12 signature. KqPNSAiR

Chain	Residue	Details
W	LYS60-ARG67

site_id	PS00056
Number of Residues	13
Details	RIBOSOMAL_S17 Ribosomal protein S17 signature. GDiVtVgEcRPLS

Chain	Residue	Details
K	GLY123-SER135

site_id	PS00362
Number of Residues	31
Details	RIBOSOMAL_S15 Ribosomal protein S15 signature. VrkHLernRkDkdAkfrLilIesrihrLarY

Chain	Residue	Details
M	VAL98-TYR128

site_id	PS00528
Number of Residues	15
Details	RIBOSOMAL_S4E Ribosomal protein S4e signature. HlKRVAaPkhWmLdK

Chain	Residue	Details
D	HIS8-LYS22

site_id	PS00529
Number of Residues	23
Details	RIBOSOMAL_S24E Ribosomal protein S24e signature. FGggKTtGFGmIYDSldyakknE

Chain	Residue	Details
X	PHE64-GLU86

site_id	PS00548
Number of Residues	37
Details	RIBOSOMAL_S3 Ribosomal protein S3 signature. AKsmkfvdGlMihSgdpVnyyVDtavrhvlLrqGvlG

Chain	Residue	Details
B	ALA147-GLY183

site_id	PS00578
Number of Residues	12
Details	RIBOSOMAL_S6E Ribosomal protein S6e signature. ISGGnDkqGfPM

Chain	Residue	Details
F	ILE52-MET63

site_id	PS00585
Number of Residues	33
Details	RIBOSOMAL_S5 Ribosomal protein S5 signature. GQrtrFkAfvAIGDyn.GhVGlGvkcsk.EVat.AI

Chain	Residue	Details
A	GLY119-ILE151

site_id	PS00632
Number of Residues	25
Details	RIBOSOMAL_S4 Ribosomal protein S4 signature. LErRLqtqVFKlglAkSihhARvLI

Chain	Residue	Details
I	LEU106-ILE130

site_id	PS00712
Number of Residues	16
Details	RIBOSOMAL_S17E Ribosomal protein S17e signature. IpSKkLRNkIAGYvTH

Chain	Residue	Details
R	ILE41-HIS56

site_id	PS00733
Number of Residues	8
Details	RIBOSOMAL_S26E Ribosomal protein S26e signature. YCVSCAIH

Chain	Residue	Details
Z	TYR73-HIS80

site_id	PS00948
Number of Residues	14
Details	RIBOSOMAL_S7E Ribosomal protein S7e signature. RLvRELEKKFSgKH

Chain	Residue	Details
G	ARG78-HIS91

site_id	PS00962
Number of Residues	12
Details	RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. VlKFLAAGTHLG

Chain	Residue	Details
h	VAL15-GLY26

site_id	PS00963
Number of Residues	25
Details	RIBOSOMAL_S2_2 Ribosomal protein S2 signature 2. PrlLVVtDpraDhqpLtEasyvNLP

Chain	Residue	Details
h	PRO119-PRO143

site_id	PS00996
Number of Residues	9
Details	RIBOSOMAL_S21E Ribosomal protein S21e signature. LYVPRKCSA

Chain	Residue	Details
V	LEU11-ALA19

site_id	PS01168
Number of Residues	33
Details	RIBOSOMAL_S27E Ribosomal protein S27e signature. KCpgCykittvFShAqtvvlCvgCStvLcqPtG

Chain	Residue	Details
a	LYS36-GLY68

site_id	PS01191
Number of Residues	13
Details	RIBOSOMAL_S3AE Ribosomal protein S3Ae signature. LkGRVfEvSLaDL

Chain	Residue	Details
C	LEU62-LEU74

site_id	PS01193
Number of Residues	20
Details	RIBOSOMAL_S8E Ribosomal protein S8e signature. RrkTGGkrkpy.HkKrKyELG

Chain	Residue	Details
H	ARG11-GLY30

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	31
Details	Domain: {"description":"BetaCoV Nsp1 C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01308","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Binds 40S ribosomal subunit","evidences":[{"source":"PubMed","id":"29987188","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)