9NB5
Cryo-EM structure of the autoinhibitory CD163 trimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005044 | molecular_function | scavenger receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006953 | biological_process | acute-phase response |
| A | 0006954 | biological_process | inflammatory response |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0030666 | cellular_component | endocytic vesicle membrane |
| A | 0097110 | molecular_function | scaffold protein binding |
| B | 0005044 | molecular_function | scavenger receptor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006953 | biological_process | acute-phase response |
| B | 0006954 | biological_process | inflammatory response |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0016192 | biological_process | vesicle-mediated transport |
| B | 0030666 | cellular_component | endocytic vesicle membrane |
| B | 0097110 | molecular_function | scaffold protein binding |
| C | 0005044 | molecular_function | scavenger receptor activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006953 | biological_process | acute-phase response |
| C | 0006954 | biological_process | inflammatory response |
| C | 0009897 | cellular_component | external side of plasma membrane |
| C | 0016020 | cellular_component | membrane |
| C | 0016192 | biological_process | vesicle-mediated transport |
| C | 0030666 | cellular_component | endocytic vesicle membrane |
| C | 0097110 | molecular_function | scaffold protein binding |
Functional Information from PROSITE/UniProt
| site_id | PS00420 |
| Number of Residues | 38 |
| Details | SRCR_1 SRCR domain signature. GenkcsGrvEvkvqeeWGtvCnngWsmeavsviCnqlG |
| Chain | Residue | Details |
| A | GLY56-GLY93 | |
| A | GLY271-GLY308 | |
| A | GLY724-GLY761 | |
| A | GLY934-GLY971 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 300 |
| Details | Domain: {"description":"SRCR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 300 |
| Details | Domain: {"description":"SRCR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 300 |
| Details | Domain: {"description":"SRCR 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 300 |
| Details | Domain: {"description":"SRCR 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 300 |
| Details | Domain: {"description":"SRCR 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 300 |
| Details | Domain: {"description":"SRCR 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 306 |
| Details | Domain: {"description":"SRCR 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 300 |
| Details | Domain: {"description":"SRCR 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 12 |
| Details | Site: {"description":"Cleavage; in calcium-free condition"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
