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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9N9G

Cryo-EM structure of the human Hec1-Nuf2 dimer bound to the paclitaxel-stabilized microtubule

Functional Information from GO Data
ChainGOidnamespacecontents
10000070biological_processmitotic sister chromatid segregation
10000132biological_processestablishment of mitotic spindle orientation
10000278biological_processmitotic cell cycle
10000775cellular_componentchromosome, centromeric region
10000776cellular_componentkinetochore
10000940cellular_componentouter kinetochore
10005515molecular_functionprotein binding
10005634cellular_componentnucleus
10005654cellular_componentnucleoplasm
10005737cellular_componentcytoplasm
10005813cellular_componentcentrosome
10005829cellular_componentcytosol
10007052biological_processmitotic spindle organization
10007057biological_processspindle assembly involved in female meiosis I
10007059biological_processchromosome segregation
10007094biological_processmitotic spindle assembly checkpoint signaling
10008017molecular_functionmicrotubule binding
10008315biological_processG2/MI transition of meiotic cell cycle
10008608biological_processattachment of spindle microtubules to kinetochore
10016020cellular_componentmembrane
10016607cellular_componentnuclear speck
10030332molecular_functioncyclin binding
10031262cellular_componentNdc80 complex
10042802molecular_functionidentical protein binding
10051276biological_processchromosome organization
10051298biological_processcentrosome duplication
10051310biological_processmetaphase chromosome alignment
10051315biological_processattachment of mitotic spindle microtubules to kinetochore
10090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
10140483molecular_functionkinetochore adaptor activity
a0000226biological_processmicrotubule cytoskeleton organization
a0000278biological_processmitotic cell cycle
a0003924molecular_functionGTPase activity
a0005200molecular_functionstructural constituent of cytoskeleton
a0005525molecular_functionGTP binding
a0005856cellular_componentcytoskeleton
a0015630cellular_componentmicrotubule cytoskeleton
a0030182biological_processneuron differentiation
A0000226biological_processmicrotubule cytoskeleton organization
A0000278biological_processmitotic cell cycle
A0003924molecular_functionGTPase activity
A0005200molecular_functionstructural constituent of cytoskeleton
A0005525molecular_functionGTP binding
A0005856cellular_componentcytoskeleton
A0015630cellular_componentmicrotubule cytoskeleton
A0030182biological_processneuron differentiation
b0000278biological_processmitotic cell cycle
b0001764biological_processneuron migration
b0005200molecular_functionstructural constituent of cytoskeleton
b0005515molecular_functionprotein binding
b0005525molecular_functionGTP binding
b0005856cellular_componentcytoskeleton
b0007010biological_processcytoskeleton organization
B0000278biological_processmitotic cell cycle
B0001764biological_processneuron migration
B0005200molecular_functionstructural constituent of cytoskeleton
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005856cellular_componentcytoskeleton
B0007010biological_processcytoskeleton organization
f0000776cellular_componentkinetochore
f0000940cellular_componentouter kinetochore
f0005515molecular_functionprotein binding
f0005634cellular_componentnucleus
f0005654cellular_componentnucleoplasm
f0005829cellular_componentcytosol
f0007059biological_processchromosome segregation
f0007094biological_processmitotic spindle assembly checkpoint signaling
f0008017molecular_functionmicrotubule binding
f0008608biological_processattachment of spindle microtubules to kinetochore
f0016020cellular_componentmembrane
f0031262cellular_componentNdc80 complex
f0044877molecular_functionprotein-containing complex binding
f0045132biological_processmeiotic chromosome segregation
f0051315biological_processattachment of mitotic spindle microtubules to kinetochore
f0051383biological_processkinetochore organization
F0000776cellular_componentkinetochore
F0000940cellular_componentouter kinetochore
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005829cellular_componentcytosol
F0007059biological_processchromosome segregation
F0007094biological_processmitotic spindle assembly checkpoint signaling
F0008017molecular_functionmicrotubule binding
F0008608biological_processattachment of spindle microtubules to kinetochore
F0016020cellular_componentmembrane
F0031262cellular_componentNdc80 complex
F0044877molecular_functionprotein-containing complex binding
F0045132biological_processmeiotic chromosome segregation
F0051315biological_processattachment of mitotic spindle microtubules to kinetochore
F0051383biological_processkinetochore organization
n0000070biological_processmitotic sister chromatid segregation
n0000132biological_processestablishment of mitotic spindle orientation
n0000278biological_processmitotic cell cycle
n0000775cellular_componentchromosome, centromeric region
n0000776cellular_componentkinetochore
n0000940cellular_componentouter kinetochore
n0005515molecular_functionprotein binding
n0005634cellular_componentnucleus
n0005654cellular_componentnucleoplasm
n0005737cellular_componentcytoplasm
n0005813cellular_componentcentrosome
n0005829cellular_componentcytosol
n0007052biological_processmitotic spindle organization
n0007057biological_processspindle assembly involved in female meiosis I
n0007059biological_processchromosome segregation
n0007094biological_processmitotic spindle assembly checkpoint signaling
n0008017molecular_functionmicrotubule binding
n0008315biological_processG2/MI transition of meiotic cell cycle
n0008608biological_processattachment of spindle microtubules to kinetochore
n0016020cellular_componentmembrane
n0016607cellular_componentnuclear speck
n0030332molecular_functioncyclin binding
n0031262cellular_componentNdc80 complex
n0042802molecular_functionidentical protein binding
n0051276biological_processchromosome organization
n0051298biological_processcentrosome duplication
n0051310biological_processmetaphase chromosome alignment
n0051315biological_processattachment of mitotic spindle microtubules to kinetochore
n0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
n0140483molecular_functionkinetochore adaptor activity
N0000070biological_processmitotic sister chromatid segregation
N0000132biological_processestablishment of mitotic spindle orientation
N0000278biological_processmitotic cell cycle
N0000775cellular_componentchromosome, centromeric region
N0000776cellular_componentkinetochore
N0000940cellular_componentouter kinetochore
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005737cellular_componentcytoplasm
N0005813cellular_componentcentrosome
N0005829cellular_componentcytosol
N0007052biological_processmitotic spindle organization
N0007057biological_processspindle assembly involved in female meiosis I
N0007059biological_processchromosome segregation
N0007094biological_processmitotic spindle assembly checkpoint signaling
N0008017molecular_functionmicrotubule binding
N0008315biological_processG2/MI transition of meiotic cell cycle
N0008608biological_processattachment of spindle microtubules to kinetochore
N0016020cellular_componentmembrane
N0016607cellular_componentnuclear speck
N0030332molecular_functioncyclin binding
N0031262cellular_componentNdc80 complex
N0042802molecular_functionidentical protein binding
N0051276biological_processchromosome organization
N0051298biological_processcentrosome duplication
N0051310biological_processmetaphase chromosome alignment
N0051315biological_processattachment of mitotic spindle microtubules to kinetochore
N0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
N0140483molecular_functionkinetochore adaptor activity
Functional Information from PROSITE/UniProt
site_idPS00227
Number of Residues7
DetailsTUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG
ChainResidueDetails
BGLY142-GLY148
AGLY142-GLY148
site_idPS00228
Number of Residues4
DetailsTUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI
ChainResidueDetails
BMET1-ILE4
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues246
DetailsRegion: {"description":"Interaction with RB1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues26
DetailsCompositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30409912","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30409912","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by NEK2","evidences":[{"source":"PubMed","id":"12386167","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9D0F1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues59
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues6
DetailsMotif: {"description":"MREC motif","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsActive site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues36
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsSite: {"description":"Involved in polymerization","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"UniProtKB","id":"P68369","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"Q71U36","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues6
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues6
DetailsMotif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues16
DetailsCompositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P99024","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"Q13885","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues2
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"UniProtKB","id":"Q2T9S0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

254587

PDB entries from 2026-06-03

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