9MN6

Structure of the human mitochondrial late-stage transcription initiation complex, IC8

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000179	molecular_function	rRNA (adenine-N6,N6-)-dimethyltransferase activity
B	0003723	molecular_function	RNA binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006351	biological_process	DNA-templated transcription
B	0006364	biological_process	rRNA processing
B	0006390	biological_process	mitochondrial transcription
B	0006391	biological_process	transcription initiation at mitochondrial promoter
B	0008168	molecular_function	methyltransferase activity
B	0008988	molecular_function	rRNA (adenine-N6-)-methyltransferase activity
B	0016740	molecular_function	transferase activity
B	0031167	biological_process	rRNA methylation
B	0032259	biological_process	methylation
B	0034246	molecular_function	mitochondrial transcription factor activity
B	0042645	cellular_component	mitochondrial nucleoid
E	0000175	molecular_function	3'-5'-RNA exonuclease activity
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0001018	molecular_function	mitochondrial promoter sequence-specific DNA binding
E	0003723	molecular_function	RNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006264	biological_process	mitochondrial DNA replication
E	0006390	biological_process	mitochondrial transcription
E	0006391	biological_process	transcription initiation at mitochondrial promoter
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0032991	cellular_component	protein-containing complex
E	0034062	molecular_function	5'-3' RNA polymerase activity
E	0034245	cellular_component	mitochondrial DNA-directed RNA polymerase complex
E	0042645	cellular_component	mitochondrial nucleoid
E	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00489
Number of Residues	15
Details	RNA_POL_PHAGE_2 Bacteriophage-type RNA polymerase family active site signature 2. ItRkvvKqtVMTvvY

Chain	Residue	Details
E	ILE985-TYR999

---

site_id	PS00900
Number of Residues	12
Details	RNA_POL_PHAGE_1 Bacteriophage-type RNA polymerase family active site signature 1. PVhqDGSCNGLQ

Chain	Residue	Details
E	PRO918-GLN929

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	428
Details	Region: {"description":"Mediates interaction with TEFM","evidences":[{"source":"PubMed","id":"21278163","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"29149603","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ERP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ERQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01026","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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