Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9MLC

Pol II-DSIF-SPT6-PAF1c-TFIIS-IWS1-ELOF1-LEDGF-nucleosome activated elongation complex Composite map T

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000781	cellular_component	chromosome, telomeric region
B	0001172	biological_process	RNA-templated transcription
B	0003682	molecular_function	chromatin binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005665	cellular_component	RNA polymerase II, core complex
B	0006354	biological_process	DNA-templated transcription elongation
B	0006366	biological_process	transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006368	biological_process	transcription elongation by RNA polymerase II
B	0034062	molecular_function	5'-3' RNA polymerase activity
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005665	cellular_component	RNA polymerase II, core complex
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0016607	cellular_component	nuclear speck
E	0005634	cellular_component	nucleus
E	0005665	cellular_component	RNA polymerase II, core complex
F	0001650	cellular_component	fibrillar center
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0006360	biological_process	transcription by RNA polymerase I
F	0006362	biological_process	transcription elongation by RNA polymerase I
F	0006366	biological_process	transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006368	biological_process	transcription elongation by RNA polymerase II
F	0006383	biological_process	transcription by RNA polymerase III
F	0006384	biological_process	transcription initiation at RNA polymerase III promoter
F	0006386	biological_process	termination of RNA polymerase III transcription
F	0042797	biological_process	tRNA transcription by RNA polymerase III
G	0005634	cellular_component	nucleus
G	0006352	biological_process	DNA-templated transcription initiation
G	0055029	cellular_component	nuclear DNA-directed RNA polymerase complex
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0006351	biological_process	DNA-templated transcription
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0006338	biological_process	chromatin remodeling
i	0010467	biological_process	gene expression
i	0010793	biological_process	regulation of mRNA export from nucleus
i	0016973	biological_process	poly(A)+ mRNA export from nucleus
i	0050684	biological_process	regulation of mRNA processing
i	0140673	biological_process	transcription elongation-coupled chromatin remodeling
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0006368	biological_process	transcription elongation by RNA polymerase II
I	0008270	molecular_function	zinc ion binding
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0005634	cellular_component	nucleus
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005736	cellular_component	RNA polymerase I complex
J	0006360	biological_process	transcription by RNA polymerase I
J	0006366	biological_process	transcription by RNA polymerase II
J	0008270	molecular_function	zinc ion binding
J	0042797	biological_process	tRNA transcription by RNA polymerase III
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
L	0001650	cellular_component	fibrillar center
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0006362	biological_process	transcription elongation by RNA polymerase I
L	0006366	biological_process	transcription by RNA polymerase II
L	0006367	biological_process	transcription initiation at RNA polymerase II promoter
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0006383	biological_process	transcription by RNA polymerase III
L	0006384	biological_process	transcription initiation at RNA polymerase III promoter
L	0006386	biological_process	termination of RNA polymerase III transcription
O	0000993	molecular_function	RNA polymerase II complex binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005694	cellular_component	chromosome
O	0006283	biological_process	transcription-coupled nucleotide-excision repair
O	0008023	cellular_component	transcription elongation factor complex
O	0030674	molecular_function	protein-macromolecule adaptor activity
Q	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Q	0000791	cellular_component	euchromatin
Q	0000993	molecular_function	RNA polymerase II complex binding
Q	0001711	biological_process	endodermal cell fate commitment
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0006325	biological_process	chromatin organization
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0006368	biological_process	transcription elongation by RNA polymerase II
Q	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
Q	0016593	cellular_component	Cdc73/Paf1 complex
Q	0016607	cellular_component	nuclear speck
Q	0019827	biological_process	stem cell population maintenance
Q	0042169	molecular_function	SH2 domain binding
Q	0045638	biological_process	negative regulation of myeloid cell differentiation
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0070102	biological_process	interleukin-6-mediated signaling pathway
Q	0071222	biological_process	cellular response to lipopolysaccharide
S	0003711	molecular_function	transcription elongation factor activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005669	cellular_component	transcription factor TFIID complex
S	0006368	biological_process	transcription elongation by RNA polymerase II
U	0001650	cellular_component	fibrillar center
U	0001711	biological_process	endodermal cell fate commitment
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0006368	biological_process	transcription elongation by RNA polymerase II
U	0016593	cellular_component	Cdc73/Paf1 complex
U	0019827	biological_process	stem cell population maintenance
U	0031124	biological_process	mRNA 3'-end processing
U	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
U	0045638	biological_process	negative regulation of myeloid cell differentiation
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	1990269	molecular_function	RNA polymerase II C-terminal domain phosphoserine binding
V	0000122	biological_process	negative regulation of transcription by RNA polymerase II
V	0000993	molecular_function	RNA polymerase II complex binding
V	0001650	cellular_component	fibrillar center
V	0001711	biological_process	endodermal cell fate commitment
V	0003682	molecular_function	chromatin binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0006368	biological_process	transcription elongation by RNA polymerase II
V	0016020	cellular_component	membrane
V	0016593	cellular_component	Cdc73/Paf1 complex
V	0019827	biological_process	stem cell population maintenance
V	0031124	biological_process	mRNA 3'-end processing
V	0034504	biological_process	protein localization to nucleus
V	0045638	biological_process	negative regulation of myeloid cell differentiation
V	0045944	biological_process	positive regulation of transcription by RNA polymerase II
V	0071222	biological_process	cellular response to lipopolysaccharide
V	1902808	biological_process	positive regulation of cell cycle G1/S phase transition
W	0000791	cellular_component	euchromatin
W	0000956	biological_process	nuclear-transcribed mRNA catabolic process
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0006368	biological_process	transcription elongation by RNA polymerase II
W	0016593	cellular_component	Cdc73/Paf1 complex
W	0045638	biological_process	negative regulation of myeloid cell differentiation
W	0055087	cellular_component	Ski complex
W	0070478	biological_process	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay
W	0072344	biological_process	rescue of stalled cytosolic ribosome
X	0000122	biological_process	negative regulation of transcription by RNA polymerase II
X	0000781	cellular_component	chromosome, telomeric region
X	0000993	molecular_function	RNA polymerase II complex binding
X	0001711	biological_process	endodermal cell fate commitment
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0006368	biological_process	transcription elongation by RNA polymerase II
X	0008285	biological_process	negative regulation of cell population proliferation
X	0016593	cellular_component	Cdc73/Paf1 complex
X	0019827	biological_process	stem cell population maintenance
X	0030177	biological_process	positive regulation of Wnt signaling pathway
X	0031124	biological_process	mRNA 3'-end processing
X	0031442	biological_process	positive regulation of mRNA 3'-end processing
X	0031648	biological_process	protein destabilization
X	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
X	0045638	biological_process	negative regulation of myeloid cell differentiation
X	0045944	biological_process	positive regulation of transcription by RNA polymerase II
X	0048147	biological_process	negative regulation of fibroblast proliferation
X	0050680	biological_process	negative regulation of epithelial cell proliferation
X	0071222	biological_process	cellular response to lipopolysaccharide
X	1902808	biological_process	positive regulation of cell cycle G1/S phase transition
X	2000134	biological_process	negative regulation of G1/S transition of mitotic cell cycle
Y	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Y	0000993	molecular_function	RNA polymerase II complex binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0006355	biological_process	regulation of DNA-templated transcription
Y	0006368	biological_process	transcription elongation by RNA polymerase II
Y	0032044	cellular_component	DSIF complex
Y	0032785	biological_process	negative regulation of DNA-templated transcription, elongation
Y	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
Y	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
Y	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Y	0046982	molecular_function	protein heterodimerization activity
Y	0140870	molecular_function	RNA polymerase inhibitor activity
Y	0160239	biological_process	transcription pausing by RNA polymerase II
Z	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Z	0003682	molecular_function	chromatin binding
Z	0003723	molecular_function	RNA binding
Z	0003729	molecular_function	mRNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0006368	biological_process	transcription elongation by RNA polymerase II
Z	0016239	biological_process	positive regulation of macroautophagy
Z	0019899	molecular_function	enzyme binding
Z	0032044	cellular_component	DSIF complex
Z	0032785	biological_process	negative regulation of DNA-templated transcription, elongation
Z	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
Z	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Z	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Z	0046982	molecular_function	protein heterodimerization activity
Z	0140870	molecular_function	RNA polymerase inhibitor activity
Z	0160239	biological_process	transcription pausing by RNA polymerase II

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI

Chain	Residue	Details
C	ASP136-ILE148

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
I	TYR112-HIS118

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
C	ASN32-PRO72

site_id	PS00466
Number of Residues	36
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CgkCkkknctytqVQTRSaDEPmttfvvCne...CgnrW

Chain	Residue	Details
S	CYS263-TRP298
I	CYS86-TRP123

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. AASSslDaHIRLWDL

Chain	Residue	Details
W	ALA79-LEU93

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
I	PHE16-CYS42

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
K	ILE35-PRO66

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY932-THR944

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI17
Number of Residues	45
Details	Zinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	42
Details	Zinc finger: {"description":"TFIIS-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10145","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38316879","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B3D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	34
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	33
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	33
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	33
Details	Repeat: {"description":"TPR 4"}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	33
Details	Repeat: {"description":"TPR 5"}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	33
Details	Repeat: {"description":"TPR 6"}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	33
Details	Repeat: {"description":"TPR 7"}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	32
Details	Repeat: {"description":"TPR 8"}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	33
Details	Repeat: {"description":"TPR 9"}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	33
Details	Repeat: {"description":"TPR 10"}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	33
Details	Repeat: {"description":"TPR 11"}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	32
Details	Repeat: {"description":"TPR 12"}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	33
Details	Repeat: {"description":"TPR 13"}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	33
Details	Repeat: {"description":"TPR 14"}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	33
Details	Repeat: {"description":"TPR 15"}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	33
Details	Repeat: {"description":"TPR 16"}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	116
Details	Domain: {"description":"TFIIS central","evidences":[{"source":"PROSITE-ProRule","id":"PRU00651","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00472","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IY6","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	43
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	39
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	39
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	41
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	39
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	39
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	38
Details	Region: {"description":"Interaction with SUPT5H"}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28892040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5OIK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	33
Details	Domain: {"description":"KOW 1"}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	31
Details	Domain: {"description":"KOW 2"}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	31
Details	Domain: {"description":"KOW 3"}

Chain

Residue

Details

site_id	SWS_FT_FI60
Number of Residues	33
Details	Domain: {"description":"KOW 4"}

Chain

Residue

Details

site_id	SWS_FT_FI61
Number of Residues	33
Details	Domain: {"description":"KOW 5"}

Chain

Residue

Details

site_id	SWS_FT_FI62
Number of Residues	5
Details	Repeat: {"description":"CTR1-1; approximate"}

Chain

Residue

Details

site_id	SWS_FT_FI63
Number of Residues	5
Details	Repeat: {"description":"CTR1-2"}

Chain

Residue

Details

site_id	SWS_FT_FI64
Number of Residues	6
Details	Repeat: {"description":"CTR1-4"}

Chain

Residue

Details

site_id	SWS_FT_FI65
Number of Residues	94
Details	Region: {"description":"Interaction with SUPT4H1"}

Chain

Residue

Details

site_id	SWS_FT_FI66
Number of Residues	6
Details	Motif: {"description":"UBR5-degron","evidences":[{"source":"PubMed","id":"37478862","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI67
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O55201","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI68
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by CDK9","evidences":[{"source":"PubMed","id":"10757782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16427012","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI69
Number of Residues	78
Details	Domain: {"description":"TFIIS N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00649","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI70
Number of Residues	11
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)