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9MHF

Cryo-EM reconstruction of PI3KC3-C1 in complex with Human RAB1A(Q70L)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000425biological_processpexophagy
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005770cellular_componentlate endosome
A0005776cellular_componentautophagosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005929cellular_componentcilium
A0005930cellular_componentaxoneme
A0006468biological_processprotein phosphorylation
A0006622biological_processprotein targeting to lysosome
A0006623biological_processprotein targeting to vacuole
A0010506biological_processregulation of autophagy
A0015630cellular_componentmicrotubule cytoskeleton
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016241biological_processregulation of macroautophagy
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0030670cellular_componentphagocytic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0032465biological_processregulation of cytokinesis
A0032801biological_processreceptor catabolic process
A0034271cellular_componentphosphatidylinositol 3-kinase complex, class III, type I
A0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
A0035032cellular_componentphosphatidylinositol 3-kinase complex, class III
A0036064cellular_componentciliary basal body
A0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
A0042149biological_processcellular response to glucose starvation
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0045022biological_processearly endosome to late endosome transport
A0045171cellular_componentintercellular bridge
A0045324biological_processlate endosome to vacuole transport
A0071561cellular_componentnucleus-vacuole junction
A0097352biological_processautophagosome maturation
A0106310molecular_functionprotein serine kinase activity
B0000045biological_processautophagosome assembly
B0000166molecular_functionnucleotide binding
B0000407cellular_componentphagophore assembly site
B0000425biological_processpexophagy
B0004672molecular_functionprotein kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005770cellular_componentlate endosome
B0005776cellular_componentautophagosome
B0005777cellular_componentperoxisome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005930cellular_componentaxoneme
B0006622biological_processprotein targeting to lysosome
B0006629biological_processlipid metabolic process
B0006897biological_processendocytosis
B0006914biological_processautophagy
B0007032biological_processendosome organization
B0009267biological_processcellular response to starvation
B0010506biological_processregulation of autophagy
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016241biological_processregulation of macroautophagy
B0016301molecular_functionkinase activity
B0016303molecular_function1-phosphatidylinositol-3-kinase activity
B0016485biological_processprotein processing
B0016740molecular_functiontransferase activity
B0016773molecular_functionphosphotransferase activity, alcohol group as acceptor
B0030496cellular_componentmidbody
B0030670cellular_componentphagocytic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0032465biological_processregulation of cytokinesis
B0034271cellular_componentphosphatidylinositol 3-kinase complex, class III, type I
B0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
B0034497biological_processprotein localization to phagophore assembly site
B0035032cellular_componentphosphatidylinositol 3-kinase complex, class III
B0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
B0042149biological_processcellular response to glucose starvation
B0043201biological_processresponse to L-leucine
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0044754cellular_componentautolysosome
B0044829biological_processpositive regulation by host of viral genome replication
B0045022biological_processearly endosome to late endosome transport
B0045335cellular_componentphagocytic vesicle
B0045954biological_processpositive regulation of natural killer cell mediated cytotoxicity
B0046854biological_processphosphatidylinositol phosphate biosynthetic process
B0048015biological_processphosphatidylinositol-mediated signaling
B0048488biological_processsynaptic vesicle endocytosis
B0051301biological_processcell division
B0052742molecular_functionphosphatidylinositol kinase activity
B0060333biological_processtype II interferon-mediated signaling pathway
B0070102biological_processinterleukin-6-mediated signaling pathway
B0097352biological_processautophagosome maturation
B0098794cellular_componentpostsynapse
B0098830cellular_componentpresynaptic endosome
B0098845cellular_componentpostsynaptic endosome
B0098978cellular_componentglutamatergic synapse
B0098982cellular_componentGABA-ergic synapse
B1903061biological_processpositive regulation of protein lipidation
C0000045biological_processautophagosome assembly
C0000407cellular_componentphagophore assembly site
C0000421cellular_componentautophagosome membrane
C0000423biological_processmitophagy
C0001933biological_processnegative regulation of protein phosphorylation
C0001934biological_processpositive regulation of protein phosphorylation
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005776cellular_componentautophagosome
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005930cellular_componentaxoneme
C0006622biological_processprotein targeting to lysosome
C0006914biological_processautophagy
C0008333biological_processendosome to lysosome transport
C0009267biological_processcellular response to starvation
C0010608biological_processpost-transcriptional regulation of gene expression
C0016020cellular_componentmembrane
C0016236biological_processmacroautophagy
C0016240biological_processautophagosome membrane docking
C0016241biological_processregulation of macroautophagy
C0031410cellular_componentcytoplasmic vesicle
C0032991cellular_componentprotein-containing complex
C0034045cellular_componentphagophore assembly site membrane
C0035014molecular_functionphosphatidylinositol 3-kinase regulator activity
C0035032cellular_componentphosphatidylinositol 3-kinase complex, class III
C0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
C0042149biological_processcellular response to glucose starvation
C0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
C0043495molecular_functionprotein-membrane adaptor activity
C0044233cellular_componentmitochondria-associated endoplasmic reticulum membrane contact site
C0045022biological_processearly endosome to late endosome transport
C0045087biological_processinnate immune response
C0045335cellular_componentphagocytic vesicle
C0051020molecular_functionGTPase binding
C0051607biological_processdefense response to virus
C0061635biological_processregulation of protein complex stability
C0090207biological_processregulation of triglyceride metabolic process
C0097352biological_processautophagosome maturation
C0097629cellular_componentextrinsic component of omegasome membrane
C0097632cellular_componentextrinsic component of phagophore assembly site membrane
C0098780biological_processresponse to mitochondrial depolarisation
C0141039molecular_functionphosphatidylinositol 3-kinase inhibitor activity
D0000045biological_processautophagosome assembly
D0000407cellular_componentphagophore assembly site
D0000423biological_processmitophagy
D0001666biological_processresponse to hypoxia
D0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005768cellular_componentendosome
D0005776cellular_componentautophagosome
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0005802cellular_componenttrans-Golgi network
D0005829cellular_componentcytosol
D0006622biological_processprotein targeting to lysosome
D0006897biological_processendocytosis
D0006914biological_processautophagy
D0006915biological_processapoptotic process
D0006968biological_processcellular defense response
D0006995biological_processcellular response to nitrogen starvation
D0007040biological_processlysosome organization
D0007080biological_processmitotic metaphase chromosome alignment
D0007254biological_processJNK cascade
D0007623biological_processcircadian rhythm
D0008285biological_processnegative regulation of cell population proliferation
D0009410biological_processresponse to xenobiotic stimulus
D0010008cellular_componentendosome membrane
D0010040biological_processresponse to iron(II) ion
D0010288biological_processresponse to lead ion
D0010506biological_processregulation of autophagy
D0010507biological_processnegative regulation of autophagy
D0010508biological_processpositive regulation of autophagy
D0010613biological_processpositive regulation of cardiac muscle hypertrophy
D0016020cellular_componentmembrane
D0016236biological_processmacroautophagy
D0016241biological_processregulation of macroautophagy
D0016604cellular_componentnuclear body
D0019901molecular_functionprotein kinase binding
D0030425cellular_componentdendrite
D0030674molecular_functionprotein-macromolecule adaptor activity
D0031410cellular_componentcytoplasmic vesicle
D0031625molecular_functionubiquitin protein ligase binding
D0031667biological_processresponse to nutrient levels
D0031966cellular_componentmitochondrial membrane
D0032465biological_processregulation of cytokinesis
D0032473cellular_componentcytoplasmic side of mitochondrial outer membrane
D0032801biological_processreceptor catabolic process
D0032991cellular_componentprotein-containing complex
D0033197biological_processresponse to vitamin E
D0034198biological_processcellular response to amino acid starvation
D0034271cellular_componentphosphatidylinositol 3-kinase complex, class III, type I
D0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
D0035032cellular_componentphosphatidylinositol 3-kinase complex, class III
D0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
D0038066biological_processp38MAPK cascade
D0042149biological_processcellular response to glucose starvation
D0042802molecular_functionidentical protein binding
D0043066biological_processnegative regulation of apoptotic process
D0043069biological_processnegative regulation of programmed cell death
D0043548molecular_functionphosphatidylinositol 3-kinase binding
D0043652biological_processengulfment of apoptotic cell
D0045022biological_processearly endosome to late endosome transport
D0045324biological_processlate endosome to vacuole transport
D0045335cellular_componentphagocytic vesicle
D0048666biological_processneuron development
D0050435biological_processamyloid-beta metabolic process
D0051020molecular_functionGTPase binding
D0051301biological_processcell division
D0051607biological_processdefense response to virus
D0051707biological_processresponse to other organism
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0060090molecular_functionmolecular adaptor activity
D0060395biological_processSMAD protein signal transduction
D0062029biological_processpositive regulation of stress granule assembly
D0065003biological_processprotein-containing complex assembly
D0070301biological_processcellular response to hydrogen peroxide
D0071275biological_processcellular response to aluminum ion
D0071280biological_processcellular response to copper ion
D0071364biological_processcellular response to epidermal growth factor stimulus
D0090650biological_processcellular response to oxygen-glucose deprivation
D0097352biological_processautophagosome maturation
D0098780biological_processresponse to mitochondrial depolarisation
D1902425biological_processpositive regulation of attachment of mitotic spindle microtubules to kinetochore
D1902902biological_processnegative regulation of autophagosome assembly
D1905672biological_processnegative regulation of lysosome organization
D2000786biological_processpositive regulation of autophagosome assembly
D2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
E0000045biological_processautophagosome assembly
E0000139cellular_componentGolgi membrane
E0000166molecular_functionnucleotide binding
E0003924molecular_functionGTPase activity
E0003925molecular_functionG protein activity
E0005515molecular_functionprotein binding
E0005525molecular_functionGTP binding
E0005737cellular_componentcytoplasm
E0005768cellular_componentendosome
E0005769cellular_componentearly endosome
E0005783cellular_componentendoplasmic reticulum
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0006886biological_processintracellular protein transport
E0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
E0006897biological_processendocytosis
E0006914biological_processautophagy
E0007030biological_processGolgi organization
E0012505cellular_componentendomembrane system
E0015031biological_processprotein transport
E0016020cellular_componentmembrane
E0016192biological_processvesicle-mediated transport
E0016477biological_processcell migration
E0016787molecular_functionhydrolase activity
E0019068biological_processvirion assembly
E0030252biological_processgrowth hormone secretion
E0030658cellular_componenttransport vesicle membrane
E0032402biological_processmelanosome transport
E0032757biological_processpositive regulation of interleukin-8 production
E0034446biological_processsubstrate adhesion-dependent cell spreading
E0042470cellular_componentmelanosome
E0042742biological_processdefense response to bacterium
E0045296molecular_functioncadherin binding
E0046872molecular_functionmetal ion binding
E0047496biological_processvesicle transport along microtubule
E0060271biological_processcilium assembly
E0070062cellular_componentextracellular exosome
E0090110biological_processCOPII-coated vesicle cargo loading
E0090557biological_processestablishment of endothelial intestinal barrier
E1903020biological_processpositive regulation of glycoprotein metabolic process
Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VrHgDIKteNVMV
ChainResidueDetails
AVAL144-VAL156

site_idPS00675
Number of Residues14
DetailsSIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLLiGDSGVGKscL
ChainResidueDetails
ELEU14-LEU27

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. IAAVqgNnEVSMWDM
ChainResidueDetails
AILE1201-MET1215
ALEU1256-LEU1270

site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDqlilQ
ChainResidueDetails
BPHE635-GLN649

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVitYILgVgDRHldN
ChainResidueDetails
BSER728-ASN748

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:22416225, ECO:0007744|PDB:3TKL
ChainResidueDetails
ESER20
EASP127
EALA155
ELYS156
EGLY21
EGLY23
ELYS24
ECYS26
EGLU38
EGLY69
EASN124
ELYS125

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:22416225, ECO:0000269|PubMed:22939626, ECO:0000269|PubMed:23588383, ECO:0000269|PubMed:23821544, ECO:0000269|Ref.29, ECO:0007744|PDB:2FOL, ECO:0007744|PDB:3TKL, ECO:0007744|PDB:4FMB, ECO:0007744|PDB:4FMC, ECO:0007744|PDB:4FMD, ECO:0007744|PDB:4FME, ECO:0007744|PDB:4IRU, ECO:0007744|PDB:4JVS
ChainResidueDetails
ESER25
ALYS53

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:22416225, ECO:0000269|PubMed:22939626, ECO:0000269|PubMed:23588383, ECO:0000269|PubMed:23821544, ECO:0000269|Ref.29, ECO:0007744|PDB:3TKL, ECO:0007744|PDB:4FMB, ECO:0007744|PDB:4FMC, ECO:0007744|PDB:4FMD, ECO:0007744|PDB:4FME, ECO:0007744|PDB:4IRU, ECO:0007744|PDB:4JVS
ChainResidueDetails
ETHR43
ASER853
ASER865

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:22416225, ECO:0000269|PubMed:22939626, ECO:0000269|PubMed:23588383, ECO:0000269|Ref.29, ECO:0007744|PDB:3TKL, ECO:0007744|PDB:4FMB, ECO:0007744|PDB:4FMC, ECO:0007744|PDB:4FMD, ECO:0007744|PDB:4FME, ECO:0007744|PDB:4JVS
ChainResidueDetails
EASP66

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N-acetylserine => ECO:0000269|Ref.9, ECO:0007744|PubMed:22223895
ChainResidueDetails
ESER2

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-(2-cholinephosphoryl)serine => ECO:0000269|PubMed:21822290, ECO:0000269|PubMed:22158903
ChainResidueDetails
ESER79

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000305|PubMed:1902553
ChainResidueDetails
ESER194

site_idSWS_FT_FI8
Number of Residues2
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:7991565
ChainResidueDetails
ECYS204
ECYS205

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: (Microbial infection) N-beta-linked (GlcNAc) arginine => ECO:0000269|PubMed:32504010
ChainResidueDetails
EARG72
DLYS437

site_idSWS_FT_FI10
Number of Residues3
DetailsCARBOHYD: (Microbial infection) N-beta-linked (GlcNAc) arginine => ECO:0000269|PubMed:32504010, ECO:0000269|PubMed:32974215
ChainResidueDetails
EARG74
EARG82
EARG111

site_idSWS_FT_FI11
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P51153
ChainResidueDetails
ELYS49
ELYS61

237423

PDB entries from 2025-06-11

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