9M3O
Crystal structure of human pyruvate dehydrogenase kinase isoform 1 in complex with ATP competitive inhibitor 8
This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU279 | |
| A | ASP318 | |
| A | SER337 | |
| A | GLY354 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by FGFR1 => ECO:0000269|PubMed:22195962 |
| Chain | Residue | Details |
| A | TYR136 | |
| A | TYR244 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by FGFR1, ABL1, FLT3 and JAK2 => ECO:0000269|PubMed:22195962 |
| Chain | Residue | Details |
| A | TYR243 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:26942675 |
| Chain | Residue | Details |
| A | THR338 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8BFP9 |
| Chain | Residue | Details |
| A | LYS405 |
