Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9LXE

Structure of compacted DNA-free MCM DH at 3.9 Angstroms resolution

Functional Information from GO Data
ChainGOidnamespacecontents
20000228cellular_componentnuclear chromosome
20000727biological_processdouble-strand break repair via break-induced replication
20000781cellular_componentchromosome, telomeric region
20000785cellular_componentchromatin
20003677molecular_functionDNA binding
20003678molecular_functionDNA helicase activity
20003688molecular_functionDNA replication origin binding
20003697molecular_functionsingle-stranded DNA binding
20005515molecular_functionprotein binding
20005634cellular_componentnucleus
20005654cellular_componentnucleoplasm
20005664cellular_componentnuclear origin of replication recognition complex
20005694cellular_componentchromosome
20005730cellular_componentnucleolus
20005737cellular_componentcytoplasm
20006260biological_processDNA replication
20006270biological_processDNA replication initiation
20006915biological_processapoptotic process
20016887molecular_functionATP hydrolysis activity
20017116molecular_functionsingle-stranded DNA helicase activity
20019899molecular_functionenzyme binding
20030174biological_processregulation of DNA-templated DNA replication initiation
20042393molecular_functionhistone binding
20042555cellular_componentMCM complex
20043138molecular_function3'-5' DNA helicase activity
20071162cellular_componentCMG complex
20090102biological_processcochlea development
21902975biological_processmitotic DNA replication initiation
30000727biological_processdouble-strand break repair via break-induced replication
30000781cellular_componentchromosome, telomeric region
30003677molecular_functionDNA binding
30003678molecular_functionDNA helicase activity
30003697molecular_functionsingle-stranded DNA binding
30005515molecular_functionprotein binding
30005634cellular_componentnucleus
30005654cellular_componentnucleoplasm
30005658cellular_componentalpha DNA polymerase:primase complex
30005694cellular_componentchromosome
30005730cellular_componentnucleolus
30005737cellular_componentcytoplasm
30006259biological_processDNA metabolic process
30006260biological_processDNA replication
30006270biological_processDNA replication initiation
30006271biological_processDNA strand elongation involved in DNA replication
30016020cellular_componentmembrane
30016887molecular_functionATP hydrolysis activity
30017116molecular_functionsingle-stranded DNA helicase activity
30030174biological_processregulation of DNA-templated DNA replication initiation
30042555cellular_componentMCM complex
30048471cellular_componentperinuclear region of cytoplasm
30071162cellular_componentCMG complex
31902975biological_processmitotic DNA replication initiation
40000727biological_processdouble-strand break repair via break-induced replication
40000781cellular_componentchromosome, telomeric region
40003678molecular_functionDNA helicase activity
40003697molecular_functionsingle-stranded DNA binding
40005515molecular_functionprotein binding
40005634cellular_componentnucleus
40005654cellular_componentnucleoplasm
40005694cellular_componentchromosome
40006259biological_processDNA metabolic process
40006260biological_processDNA replication
40006271biological_processDNA strand elongation involved in DNA replication
40016020cellular_componentmembrane
40016887molecular_functionATP hydrolysis activity
40017116molecular_functionsingle-stranded DNA helicase activity
40030174biological_processregulation of DNA-templated DNA replication initiation
40042555cellular_componentMCM complex
40071162cellular_componentCMG complex
41902975biological_processmitotic DNA replication initiation
50000727biological_processdouble-strand break repair via break-induced replication
50000781cellular_componentchromosome, telomeric region
50003678molecular_functionDNA helicase activity
50003697molecular_functionsingle-stranded DNA binding
50005515molecular_functionprotein binding
50005634cellular_componentnucleus
50005654cellular_componentnucleoplasm
50005694cellular_componentchromosome
50006260biological_processDNA replication
50006270biological_processDNA replication initiation
50016020cellular_componentmembrane
50016887molecular_functionATP hydrolysis activity
50017116molecular_functionsingle-stranded DNA helicase activity
50030174biological_processregulation of DNA-templated DNA replication initiation
50042555cellular_componentMCM complex
50043138molecular_function3'-5' DNA helicase activity
50071162cellular_componentCMG complex
60000727biological_processdouble-strand break repair via break-induced replication
60000781cellular_componentchromosome, telomeric region
60003678molecular_functionDNA helicase activity
60003697molecular_functionsingle-stranded DNA binding
60005515molecular_functionprotein binding
60005524molecular_functionATP binding
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
60005694cellular_componentchromosome
60006259biological_processDNA metabolic process
60006260biological_processDNA replication
60016887molecular_functionATP hydrolysis activity
60030174biological_processregulation of DNA-templated DNA replication initiation
60042555cellular_componentMCM complex
60042802molecular_functionidentical protein binding
60071162cellular_componentCMG complex
61902969biological_processmitotic DNA replication
61990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
70000727biological_processdouble-strand break repair via break-induced replication
70000781cellular_componentchromosome, telomeric region
70000785cellular_componentchromatin
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003697molecular_functionsingle-stranded DNA binding
70005515molecular_functionprotein binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005694cellular_componentchromosome
70005730cellular_componentnucleolus
70006259biological_processDNA metabolic process
70006260biological_processDNA replication
70006270biological_processDNA replication initiation
70006271biological_processDNA strand elongation involved in DNA replication
70006974biological_processDNA damage response
70009410biological_processresponse to xenobiotic stimulus
70016020cellular_componentmembrane
70016887molecular_functionATP hydrolysis activity
70017116molecular_functionsingle-stranded DNA helicase activity
70030174biological_processregulation of DNA-templated DNA replication initiation
70042325biological_processregulation of phosphorylation
70042555cellular_componentMCM complex
70071162cellular_componentCMG complex
70071364biological_processcellular response to epidermal growth factor stimulus
A0000727biological_processdouble-strand break repair via break-induced replication
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0003677molecular_functionDNA binding
A0003678molecular_functionDNA helicase activity
A0003697molecular_functionsingle-stranded DNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005730cellular_componentnucleolus
A0006259biological_processDNA metabolic process
A0006260biological_processDNA replication
A0006270biological_processDNA replication initiation
A0006271biological_processDNA strand elongation involved in DNA replication
A0006974biological_processDNA damage response
A0009410biological_processresponse to xenobiotic stimulus
A0016020cellular_componentmembrane
A0016887molecular_functionATP hydrolysis activity
A0017116molecular_functionsingle-stranded DNA helicase activity
A0030174biological_processregulation of DNA-templated DNA replication initiation
A0042325biological_processregulation of phosphorylation
A0042555cellular_componentMCM complex
A0071162cellular_componentCMG complex
A0071364biological_processcellular response to epidermal growth factor stimulus
B0000727biological_processdouble-strand break repair via break-induced replication
B0000781cellular_componentchromosome, telomeric region
B0003677molecular_functionDNA binding
B0003678molecular_functionDNA helicase activity
B0003697molecular_functionsingle-stranded DNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005658cellular_componentalpha DNA polymerase:primase complex
B0005694cellular_componentchromosome
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0006259biological_processDNA metabolic process
B0006260biological_processDNA replication
B0006270biological_processDNA replication initiation
B0006271biological_processDNA strand elongation involved in DNA replication
B0016020cellular_componentmembrane
B0016887molecular_functionATP hydrolysis activity
B0017116molecular_functionsingle-stranded DNA helicase activity
B0030174biological_processregulation of DNA-templated DNA replication initiation
B0042555cellular_componentMCM complex
B0048471cellular_componentperinuclear region of cytoplasm
B0071162cellular_componentCMG complex
B1902975biological_processmitotic DNA replication initiation
C0000727biological_processdouble-strand break repair via break-induced replication
C0000781cellular_componentchromosome, telomeric region
C0003677molecular_functionDNA binding
C0003678molecular_functionDNA helicase activity
C0003697molecular_functionsingle-stranded DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005658cellular_componentalpha DNA polymerase:primase complex
C0005694cellular_componentchromosome
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0006259biological_processDNA metabolic process
C0006260biological_processDNA replication
C0006270biological_processDNA replication initiation
C0006271biological_processDNA strand elongation involved in DNA replication
C0016020cellular_componentmembrane
C0016887molecular_functionATP hydrolysis activity
C0017116molecular_functionsingle-stranded DNA helicase activity
C0030174biological_processregulation of DNA-templated DNA replication initiation
C0042555cellular_componentMCM complex
C0048471cellular_componentperinuclear region of cytoplasm
C0071162cellular_componentCMG complex
C1902975biological_processmitotic DNA replication initiation
D0000228cellular_componentnuclear chromosome
D0000727biological_processdouble-strand break repair via break-induced replication
D0000781cellular_componentchromosome, telomeric region
D0000785cellular_componentchromatin
D0003677molecular_functionDNA binding
D0003678molecular_functionDNA helicase activity
D0003688molecular_functionDNA replication origin binding
D0003697molecular_functionsingle-stranded DNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005664cellular_componentnuclear origin of replication recognition complex
D0005694cellular_componentchromosome
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0006260biological_processDNA replication
D0006270biological_processDNA replication initiation
D0006915biological_processapoptotic process
D0016887molecular_functionATP hydrolysis activity
D0017116molecular_functionsingle-stranded DNA helicase activity
D0019899molecular_functionenzyme binding
D0030174biological_processregulation of DNA-templated DNA replication initiation
D0042393molecular_functionhistone binding
D0042555cellular_componentMCM complex
D0043138molecular_function3'-5' DNA helicase activity
D0071162cellular_componentCMG complex
D0090102biological_processcochlea development
D1902975biological_processmitotic DNA replication initiation
E0000727biological_processdouble-strand break repair via break-induced replication
E0000781cellular_componentchromosome, telomeric region
E0003677molecular_functionDNA binding
E0003678molecular_functionDNA helicase activity
E0003697molecular_functionsingle-stranded DNA binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005658cellular_componentalpha DNA polymerase:primase complex
E0005694cellular_componentchromosome
E0005730cellular_componentnucleolus
E0005737cellular_componentcytoplasm
E0006259biological_processDNA metabolic process
E0006260biological_processDNA replication
E0006270biological_processDNA replication initiation
E0006271biological_processDNA strand elongation involved in DNA replication
E0016020cellular_componentmembrane
E0016887molecular_functionATP hydrolysis activity
E0017116molecular_functionsingle-stranded DNA helicase activity
E0030174biological_processregulation of DNA-templated DNA replication initiation
E0042555cellular_componentMCM complex
E0048471cellular_componentperinuclear region of cytoplasm
E0071162cellular_componentCMG complex
E1902975biological_processmitotic DNA replication initiation
F0000727biological_processdouble-strand break repair via break-induced replication
F0000781cellular_componentchromosome, telomeric region
F0003678molecular_functionDNA helicase activity
F0003697molecular_functionsingle-stranded DNA binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005694cellular_componentchromosome
F0006259biological_processDNA metabolic process
F0006260biological_processDNA replication
F0006271biological_processDNA strand elongation involved in DNA replication
F0016020cellular_componentmembrane
F0016887molecular_functionATP hydrolysis activity
F0017116molecular_functionsingle-stranded DNA helicase activity
F0030174biological_processregulation of DNA-templated DNA replication initiation
F0042555cellular_componentMCM complex
F0071162cellular_componentCMG complex
F1902975biological_processmitotic DNA replication initiation
G0000727biological_processdouble-strand break repair via break-induced replication
G0000781cellular_componentchromosome, telomeric region
G0003678molecular_functionDNA helicase activity
G0003697molecular_functionsingle-stranded DNA binding
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005694cellular_componentchromosome
G0006259biological_processDNA metabolic process
G0006260biological_processDNA replication
G0016887molecular_functionATP hydrolysis activity
G0030174biological_processregulation of DNA-templated DNA replication initiation
G0042555cellular_componentMCM complex
G0042802molecular_functionidentical protein binding
G0071162cellular_componentCMG complex
G1902969biological_processmitotic DNA replication
G1990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
H0000727biological_processdouble-strand break repair via break-induced replication
H0000781cellular_componentchromosome, telomeric region
H0003678molecular_functionDNA helicase activity
H0003697molecular_functionsingle-stranded DNA binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005694cellular_componentchromosome
H0006260biological_processDNA replication
H0006270biological_processDNA replication initiation
H0016020cellular_componentmembrane
H0016887molecular_functionATP hydrolysis activity
H0017116molecular_functionsingle-stranded DNA helicase activity
H0030174biological_processregulation of DNA-templated DNA replication initiation
H0042555cellular_componentMCM complex
H0043138molecular_function3'-5' DNA helicase activity
H0071162cellular_componentCMG complex
Functional Information from PROSITE/UniProt
site_idPS00847
Number of Residues9
DetailsMCM_1 MCM family signature. GVCCIDEFD
ChainResidueDetails
7GLY440-ASP448
6GLY455-ASP463
4GLY569-ASP577
5GLY440-ASP448
3GLY404-ASP412
2GLY582-ASP590
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues84
DetailsMotif: {"description":"Walker A","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues36
DetailsMotif: {"description":"Walker B","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32453425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6XTX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsSite: {"description":"Arginine finger","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues12
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues14
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues16
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues64
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32453425","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6XTX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P25206","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1330
DetailsDomain: {"description":"MCM C-terminal AAA(+) ATPase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01410","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P49717","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)","evidences":[{"source":"PubMed","id":"40940420","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P97311","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues86
DetailsRegion: {"description":"Interaction with RAD17","evidences":[{"source":"PubMed","id":"15538388","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","von Kriegsheim A.","Kolch W."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

253389

PDB entries from 2026-05-13

PDB statisticsPDBj update infoContact PDBjnumon