9LWF

Cryo-EM structure of dual sensor bound GATOR2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005765	cellular_component	lysosomal membrane
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0031503	biological_process	protein-containing complex localization
A	0031669	biological_process	cellular response to nutrient levels
A	0032289	biological_process	central nervous system myelin formation
A	0034198	biological_process	cellular response to amino acid starvation
A	0046872	molecular_function	metal ion binding
A	0048709	biological_process	oligodendrocyte differentiation
A	0061700	cellular_component	GATOR2 complex
A	0070444	biological_process	oligodendrocyte progenitor proliferation
A	1904262	biological_process	negative regulation of TORC1 signaling
A	1904263	biological_process	positive regulation of TORC1 signaling
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005765	cellular_component	lysosomal membrane
B	0005829	cellular_component	cytosol
B	0008270	molecular_function	zinc ion binding
B	0031503	biological_process	protein-containing complex localization
B	0031669	biological_process	cellular response to nutrient levels
B	0032289	biological_process	central nervous system myelin formation
B	0034198	biological_process	cellular response to amino acid starvation
B	0046872	molecular_function	metal ion binding
B	0048709	biological_process	oligodendrocyte differentiation
B	0061700	cellular_component	GATOR2 complex
B	0070444	biological_process	oligodendrocyte progenitor proliferation
B	1904262	biological_process	negative regulation of TORC1 signaling
B	1904263	biological_process	positive regulation of TORC1 signaling
C	0005515	molecular_function	protein binding
C	0005765	cellular_component	lysosomal membrane
C	0005774	cellular_component	vacuolar membrane
C	0005829	cellular_component	cytosol
C	0006914	biological_process	autophagy
C	0008270	molecular_function	zinc ion binding
C	0010506	biological_process	regulation of autophagy
C	0016239	biological_process	positive regulation of macroautophagy
C	0016567	biological_process	protein ubiquitination
C	0016740	molecular_function	transferase activity
C	0031669	biological_process	cellular response to nutrient levels
C	0032008	biological_process	positive regulation of TOR signaling
C	0034198	biological_process	cellular response to amino acid starvation
C	0046872	molecular_function	metal ion binding
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0061700	cellular_component	GATOR2 complex
C	0072659	biological_process	protein localization to plasma membrane
C	0085020	biological_process	protein K6-linked ubiquitination
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904263	biological_process	positive regulation of TORC1 signaling
D	0005515	molecular_function	protein binding
D	0005765	cellular_component	lysosomal membrane
D	0005774	cellular_component	vacuolar membrane
D	0008270	molecular_function	zinc ion binding
D	0031669	biological_process	cellular response to nutrient levels
D	0034198	biological_process	cellular response to amino acid starvation
D	0035591	molecular_function	signaling adaptor activity
D	0035859	cellular_component	Seh1-associated complex
D	0046872	molecular_function	metal ion binding
D	0061700	cellular_component	GATOR2 complex
D	0072659	biological_process	protein localization to plasma membrane
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1904263	biological_process	positive regulation of TORC1 signaling
E	0000776	cellular_component	kinetochore
E	0005515	molecular_function	protein binding
E	0005635	cellular_component	nuclear envelope
E	0005643	cellular_component	nuclear pore
E	0005765	cellular_component	lysosomal membrane
E	0005829	cellular_component	cytosol
E	0006913	biological_process	nucleocytoplasmic transport
E	0006999	biological_process	nuclear pore organization
E	0007059	biological_process	chromosome segregation
E	0007080	biological_process	mitotic metaphase chromosome alignment
E	0015031	biological_process	protein transport
E	0031080	cellular_component	nuclear pore outer ring
E	0031503	biological_process	protein-containing complex localization
E	0031669	biological_process	cellular response to nutrient levels
E	0034198	biological_process	cellular response to amino acid starvation
E	0035859	cellular_component	Seh1-associated complex
E	0051028	biological_process	mRNA transport
E	0051301	biological_process	cell division
E	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
E	0061700	cellular_component	GATOR2 complex
E	1904262	biological_process	negative regulation of TORC1 signaling
E	1904263	biological_process	positive regulation of TORC1 signaling
F	0000776	cellular_component	kinetochore
F	0005515	molecular_function	protein binding
F	0005635	cellular_component	nuclear envelope
F	0005643	cellular_component	nuclear pore
F	0005765	cellular_component	lysosomal membrane
F	0005829	cellular_component	cytosol
F	0006913	biological_process	nucleocytoplasmic transport
F	0006999	biological_process	nuclear pore organization
F	0007059	biological_process	chromosome segregation
F	0007080	biological_process	mitotic metaphase chromosome alignment
F	0015031	biological_process	protein transport
F	0031080	cellular_component	nuclear pore outer ring
F	0031503	biological_process	protein-containing complex localization
F	0031669	biological_process	cellular response to nutrient levels
F	0034198	biological_process	cellular response to amino acid starvation
F	0035859	cellular_component	Seh1-associated complex
F	0051028	biological_process	mRNA transport
F	0051301	biological_process	cell division
F	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
F	0061700	cellular_component	GATOR2 complex
F	1904262	biological_process	negative regulation of TORC1 signaling
F	1904263	biological_process	positive regulation of TORC1 signaling
G	0000776	cellular_component	kinetochore
G	0005515	molecular_function	protein binding
G	0005635	cellular_component	nuclear envelope
G	0005643	cellular_component	nuclear pore
G	0005765	cellular_component	lysosomal membrane
G	0005829	cellular_component	cytosol
G	0006913	biological_process	nucleocytoplasmic transport
G	0006999	biological_process	nuclear pore organization
G	0007059	biological_process	chromosome segregation
G	0007080	biological_process	mitotic metaphase chromosome alignment
G	0015031	biological_process	protein transport
G	0031080	cellular_component	nuclear pore outer ring
G	0031503	biological_process	protein-containing complex localization
G	0031669	biological_process	cellular response to nutrient levels
G	0034198	biological_process	cellular response to amino acid starvation
G	0035859	cellular_component	Seh1-associated complex
G	0051028	biological_process	mRNA transport
G	0051301	biological_process	cell division
G	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
G	0061700	cellular_component	GATOR2 complex
G	1904262	biological_process	negative regulation of TORC1 signaling
G	1904263	biological_process	positive regulation of TORC1 signaling
H	0000776	cellular_component	kinetochore
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005635	cellular_component	nuclear envelope
H	0005643	cellular_component	nuclear pore
H	0005654	cellular_component	nucleoplasm
H	0005765	cellular_component	lysosomal membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005829	cellular_component	cytosol
H	0006606	biological_process	protein import into nucleus
H	0006886	biological_process	intracellular protein transport
H	0006913	biological_process	nucleocytoplasmic transport
H	0012507	cellular_component	ER to Golgi transport vesicle membrane
H	0015031	biological_process	protein transport
H	0016192	biological_process	vesicle-mediated transport
H	0030127	cellular_component	COPII vesicle coat
H	0031080	cellular_component	nuclear pore outer ring
H	0031410	cellular_component	cytoplasmic vesicle
H	0031669	biological_process	cellular response to nutrient levels
H	0032008	biological_process	positive regulation of TOR signaling
H	0032527	biological_process	protein exit from endoplasmic reticulum
H	0042802	molecular_function	identical protein binding
H	0051028	biological_process	mRNA transport
H	0061700	cellular_component	GATOR2 complex
H	0070062	cellular_component	extracellular exosome
H	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
H	0090110	biological_process	COPII-coated vesicle cargo loading
H	0090114	biological_process	COPII-coated vesicle budding
H	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
H	1904262	biological_process	negative regulation of TORC1 signaling
H	1904263	biological_process	positive regulation of TORC1 signaling
I	0005515	molecular_function	protein binding
I	0005765	cellular_component	lysosomal membrane
I	0005774	cellular_component	vacuolar membrane
I	0005829	cellular_component	cytosol
I	0006914	biological_process	autophagy
I	0008270	molecular_function	zinc ion binding
I	0010506	biological_process	regulation of autophagy
I	0016239	biological_process	positive regulation of macroautophagy
I	0016567	biological_process	protein ubiquitination
I	0016740	molecular_function	transferase activity
I	0031669	biological_process	cellular response to nutrient levels
I	0032008	biological_process	positive regulation of TOR signaling
I	0034198	biological_process	cellular response to amino acid starvation
I	0046872	molecular_function	metal ion binding
I	0061630	molecular_function	ubiquitin protein ligase activity
I	0061700	cellular_component	GATOR2 complex
I	0072659	biological_process	protein localization to plasma membrane
I	0085020	biological_process	protein K6-linked ubiquitination
I	1904262	biological_process	negative regulation of TORC1 signaling
I	1904263	biological_process	positive regulation of TORC1 signaling
K	0005515	molecular_function	protein binding
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005765	cellular_component	lysosomal membrane
K	0005829	cellular_component	cytosol
K	0008270	molecular_function	zinc ion binding
K	0031503	biological_process	protein-containing complex localization
K	0031669	biological_process	cellular response to nutrient levels
K	0032289	biological_process	central nervous system myelin formation
K	0034198	biological_process	cellular response to amino acid starvation
K	0046872	molecular_function	metal ion binding
K	0048709	biological_process	oligodendrocyte differentiation
K	0061700	cellular_component	GATOR2 complex
K	0070444	biological_process	oligodendrocyte progenitor proliferation
K	1904262	biological_process	negative regulation of TORC1 signaling
K	1904263	biological_process	positive regulation of TORC1 signaling
L	0005515	molecular_function	protein binding
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005765	cellular_component	lysosomal membrane
L	0005829	cellular_component	cytosol
L	0008270	molecular_function	zinc ion binding
L	0031503	biological_process	protein-containing complex localization
L	0031669	biological_process	cellular response to nutrient levels
L	0032289	biological_process	central nervous system myelin formation
L	0034198	biological_process	cellular response to amino acid starvation
L	0046872	molecular_function	metal ion binding
L	0048709	biological_process	oligodendrocyte differentiation
L	0061700	cellular_component	GATOR2 complex
L	0070444	biological_process	oligodendrocyte progenitor proliferation
L	1904262	biological_process	negative regulation of TORC1 signaling
L	1904263	biological_process	positive regulation of TORC1 signaling
N	0005515	molecular_function	protein binding
N	0005765	cellular_component	lysosomal membrane
N	0005774	cellular_component	vacuolar membrane
N	0008270	molecular_function	zinc ion binding
N	0031669	biological_process	cellular response to nutrient levels
N	0034198	biological_process	cellular response to amino acid starvation
N	0035591	molecular_function	signaling adaptor activity
N	0035859	cellular_component	Seh1-associated complex
N	0046872	molecular_function	metal ion binding
N	0061700	cellular_component	GATOR2 complex
N	0072659	biological_process	protein localization to plasma membrane
N	1904262	biological_process	negative regulation of TORC1 signaling
N	1904263	biological_process	positive regulation of TORC1 signaling
O	0000776	cellular_component	kinetochore
O	0005515	molecular_function	protein binding
O	0005635	cellular_component	nuclear envelope
O	0005643	cellular_component	nuclear pore
O	0005765	cellular_component	lysosomal membrane
O	0005829	cellular_component	cytosol
O	0006913	biological_process	nucleocytoplasmic transport
O	0006999	biological_process	nuclear pore organization
O	0007059	biological_process	chromosome segregation
O	0007080	biological_process	mitotic metaphase chromosome alignment
O	0015031	biological_process	protein transport
O	0031080	cellular_component	nuclear pore outer ring
O	0031503	biological_process	protein-containing complex localization
O	0031669	biological_process	cellular response to nutrient levels
O	0034198	biological_process	cellular response to amino acid starvation
O	0035859	cellular_component	Seh1-associated complex
O	0051028	biological_process	mRNA transport
O	0051301	biological_process	cell division
O	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
O	0061700	cellular_component	GATOR2 complex
O	1904262	biological_process	negative regulation of TORC1 signaling
O	1904263	biological_process	positive regulation of TORC1 signaling
P	0000776	cellular_component	kinetochore
P	0005515	molecular_function	protein binding
P	0005635	cellular_component	nuclear envelope
P	0005643	cellular_component	nuclear pore
P	0005765	cellular_component	lysosomal membrane
P	0005829	cellular_component	cytosol
P	0006913	biological_process	nucleocytoplasmic transport
P	0006999	biological_process	nuclear pore organization
P	0007059	biological_process	chromosome segregation
P	0007080	biological_process	mitotic metaphase chromosome alignment
P	0015031	biological_process	protein transport
P	0031080	cellular_component	nuclear pore outer ring
P	0031503	biological_process	protein-containing complex localization
P	0031669	biological_process	cellular response to nutrient levels
P	0034198	biological_process	cellular response to amino acid starvation
P	0035859	cellular_component	Seh1-associated complex
P	0051028	biological_process	mRNA transport
P	0051301	biological_process	cell division
P	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
P	0061700	cellular_component	GATOR2 complex
P	1904262	biological_process	negative regulation of TORC1 signaling
P	1904263	biological_process	positive regulation of TORC1 signaling
Q	0000776	cellular_component	kinetochore
Q	0005515	molecular_function	protein binding
Q	0005635	cellular_component	nuclear envelope
Q	0005643	cellular_component	nuclear pore
Q	0005765	cellular_component	lysosomal membrane
Q	0005829	cellular_component	cytosol
Q	0006913	biological_process	nucleocytoplasmic transport
Q	0006999	biological_process	nuclear pore organization
Q	0007059	biological_process	chromosome segregation
Q	0007080	biological_process	mitotic metaphase chromosome alignment
Q	0015031	biological_process	protein transport
Q	0031080	cellular_component	nuclear pore outer ring
Q	0031503	biological_process	protein-containing complex localization
Q	0031669	biological_process	cellular response to nutrient levels
Q	0034198	biological_process	cellular response to amino acid starvation
Q	0035859	cellular_component	Seh1-associated complex
Q	0051028	biological_process	mRNA transport
Q	0051301	biological_process	cell division
Q	0051315	biological_process	attachment of mitotic spindle microtubules to kinetochore
Q	0061700	cellular_component	GATOR2 complex
Q	1904262	biological_process	negative regulation of TORC1 signaling
Q	1904263	biological_process	positive regulation of TORC1 signaling
R	0000776	cellular_component	kinetochore
R	0005198	molecular_function	structural molecule activity
R	0005515	molecular_function	protein binding
R	0005635	cellular_component	nuclear envelope
R	0005643	cellular_component	nuclear pore
R	0005654	cellular_component	nucleoplasm
R	0005765	cellular_component	lysosomal membrane
R	0005783	cellular_component	endoplasmic reticulum
R	0005789	cellular_component	endoplasmic reticulum membrane
R	0005829	cellular_component	cytosol
R	0006606	biological_process	protein import into nucleus
R	0006886	biological_process	intracellular protein transport
R	0006913	biological_process	nucleocytoplasmic transport
R	0012507	cellular_component	ER to Golgi transport vesicle membrane
R	0015031	biological_process	protein transport
R	0016192	biological_process	vesicle-mediated transport
R	0030127	cellular_component	COPII vesicle coat
R	0031080	cellular_component	nuclear pore outer ring
R	0031410	cellular_component	cytoplasmic vesicle
R	0031669	biological_process	cellular response to nutrient levels
R	0032008	biological_process	positive regulation of TOR signaling
R	0032527	biological_process	protein exit from endoplasmic reticulum
R	0042802	molecular_function	identical protein binding
R	0051028	biological_process	mRNA transport
R	0061700	cellular_component	GATOR2 complex
R	0070062	cellular_component	extracellular exosome
R	0070863	biological_process	positive regulation of protein exit from endoplasmic reticulum
R	0090110	biological_process	COPII-coated vesicle cargo loading
R	0090114	biological_process	COPII-coated vesicle budding
R	1902953	biological_process	positive regulation of ER to Golgi vesicle-mediated transport
R	1904262	biological_process	negative regulation of TORC1 signaling
R	1904263	biological_process	positive regulation of TORC1 signaling
U	0005515	molecular_function	protein binding
U	0005829	cellular_component	cytosol
U	0034198	biological_process	cellular response to amino acid starvation
U	0034618	molecular_function	arginine binding
U	0042802	molecular_function	identical protein binding
U	0061700	cellular_component	GATOR2 complex
U	0140299	molecular_function	molecular sensor activity
U	0140311	molecular_function	protein sequestering activity
U	1903577	biological_process	cellular response to L-arginine
U	1904262	biological_process	negative regulation of TORC1 signaling
U	1904263	biological_process	positive regulation of TORC1 signaling
V	0005515	molecular_function	protein binding
V	0005829	cellular_component	cytosol
V	0034198	biological_process	cellular response to amino acid starvation
V	0034618	molecular_function	arginine binding
V	0042802	molecular_function	identical protein binding
V	0061700	cellular_component	GATOR2 complex
V	0140299	molecular_function	molecular sensor activity
V	0140311	molecular_function	protein sequestering activity
V	1903577	biological_process	cellular response to L-arginine
V	1904262	biological_process	negative regulation of TORC1 signaling
V	1904263	biological_process	positive regulation of TORC1 signaling
X	0001932	biological_process	regulation of protein phosphorylation
X	0004601	molecular_function	peroxidase activity
X	0005092	molecular_function	GDP-dissociation inhibitor activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005765	cellular_component	lysosomal membrane
X	0005829	cellular_component	cytosol
X	0016239	biological_process	positive regulation of macroautophagy
X	0016491	molecular_function	oxidoreductase activity
X	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
X	0030308	biological_process	negative regulation of cell growth
X	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
X	0031588	cellular_component	nucleotide-activated protein kinase complex
X	0031932	cellular_component	TORC2 complex
X	0032147	biological_process	activation of protein kinase activity
X	0032542	molecular_function	sulfiredoxin activity
X	0034198	biological_process	cellular response to amino acid starvation
X	0034599	biological_process	cellular response to oxidative stress
X	0038203	biological_process	TORC2 signaling
X	0042149	biological_process	cellular response to glucose starvation
X	0042731	molecular_function	PH domain binding
X	0044877	molecular_function	protein-containing complex binding
X	0061700	cellular_component	GATOR2 complex
X	0070728	molecular_function	L-leucine binding
X	0071230	biological_process	cellular response to amino acid stimulus
X	0071233	biological_process	cellular response to L-leucine
X	0072593	biological_process	reactive oxygen species metabolic process
X	0072659	biological_process	protein localization to plasma membrane
X	0098869	biological_process	cellular oxidant detoxification
X	0140311	molecular_function	protein sequestering activity
X	1900182	biological_process	positive regulation of protein localization to nucleus
X	1902010	biological_process	negative regulation of translation in response to endoplasmic reticulum stress
X	1903432	biological_process	regulation of TORC1 signaling
X	1904262	biological_process	negative regulation of TORC1 signaling
X	1904263	biological_process	positive regulation of TORC1 signaling
X	1990253	biological_process	cellular response to leucine starvation
X	1990316	cellular_component	Atg1/ULK1 kinase complex
Y	0001932	biological_process	regulation of protein phosphorylation
Y	0004601	molecular_function	peroxidase activity
Y	0005092	molecular_function	GDP-dissociation inhibitor activity
Y	0005515	molecular_function	protein binding
Y	0005737	cellular_component	cytoplasm
Y	0005765	cellular_component	lysosomal membrane
Y	0005829	cellular_component	cytosol
Y	0016239	biological_process	positive regulation of macroautophagy
Y	0016491	molecular_function	oxidoreductase activity
Y	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
Y	0030308	biological_process	negative regulation of cell growth
Y	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
Y	0031588	cellular_component	nucleotide-activated protein kinase complex
Y	0031932	cellular_component	TORC2 complex
Y	0032147	biological_process	activation of protein kinase activity
Y	0032542	molecular_function	sulfiredoxin activity
Y	0034198	biological_process	cellular response to amino acid starvation
Y	0034599	biological_process	cellular response to oxidative stress
Y	0038203	biological_process	TORC2 signaling
Y	0042149	biological_process	cellular response to glucose starvation
Y	0042731	molecular_function	PH domain binding
Y	0044877	molecular_function	protein-containing complex binding
Y	0061700	cellular_component	GATOR2 complex
Y	0070728	molecular_function	L-leucine binding
Y	0071230	biological_process	cellular response to amino acid stimulus
Y	0071233	biological_process	cellular response to L-leucine
Y	0072593	biological_process	reactive oxygen species metabolic process
Y	0072659	biological_process	protein localization to plasma membrane
Y	0098869	biological_process	cellular oxidant detoxification
Y	0140311	molecular_function	protein sequestering activity
Y	1900182	biological_process	positive regulation of protein localization to nucleus
Y	1902010	biological_process	negative regulation of translation in response to endoplasmic reticulum stress
Y	1903432	biological_process	regulation of TORC1 signaling
Y	1904262	biological_process	negative regulation of TORC1 signaling
Y	1904263	biological_process	positive regulation of TORC1 signaling
Y	1990253	biological_process	cellular response to leucine starvation
Y	1990316	cellular_component	Atg1/ULK1 kinase complex

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATAatNgVVVTWNL

Chain	Residue	Details
C	LEU90-LEU104
C	LEU223-MET237
C	THR269-VAL283
D	LEU121-ILE135

---

site_id	PS01248
Number of Residues	37
Details	EGF_LAM_1 Laminin-type EGF-like (LE) domain signature. CshCrsevrGtqCaiCkgftFqcaichvavrgssnfC

Chain	Residue	Details
D	CYS902-CYS938

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	480
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	488
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	364
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	480
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	106
Details	Binding site: {"evidences":[{"source":"PubMed","id":"35831510","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7UHY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	Repeat: {"description":"WD 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	80
Details	Repeat: {"description":"WD 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	80
Details	Repeat: {"description":"WD 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	80
Details	Repeat: {"description":"WD 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	84
Details	Repeat: {"description":"WD 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	86
Details	Repeat: {"description":"WD 6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	82
Details	Zinc finger: {"description":"C4-type","evidences":[{"source":"PubMed","id":"35831510","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"PubMed","id":"36732624","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	153
Details	Zinc finger: {"description":"RING-type; atypical","evidences":[{"source":"PubMed","id":"35831510","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	76
Details	Repeat: {"description":"WD 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	13
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	82
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	86
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27487210","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5I2C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKB/AKT1","evidences":[{"source":"PubMed","id":"33594058","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"26612684","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26586190","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DJ4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"35114100","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---