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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9LU1

protein structure of DDB1-DDA1-DET1-Ube2e2 bound to COP1 dimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006511biological_processubiquitin-dependent protein catabolic process
A0010212biological_processresponse to ionizing radiation
A0016567biological_processprotein ubiquitination
A0016607cellular_componentnuclear speck
A0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045717biological_processnegative regulation of fatty acid biosynthetic process
A0061630molecular_functionubiquitin protein ligase activity
B0000209biological_processprotein polyubiquitination
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0016567biological_processprotein ubiquitination
B0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
B0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
B0032814biological_processregulation of natural killer cell activation
B0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
C0004842molecular_functionubiquitin-protein transferase activity
C0005515molecular_functionprotein binding
C0006513biological_processprotein monoubiquitination
C0006974biological_processDNA damage response
C0016567biological_processprotein ubiquitination
C0032020biological_processISG15-protein conjugation
C0042296molecular_functionISG15 transferase activity
C0061631molecular_functionubiquitin conjugating enzyme activity
C0070534biological_processprotein K63-linked ubiquitination
C0070936biological_processprotein K48-linked ubiquitination
C0070979biological_processprotein K11-linked ubiquitination
C1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
E0000139cellular_componentGolgi membrane
E0004842molecular_functionubiquitin-protein transferase activity
E0005515molecular_functionprotein binding
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006511biological_processubiquitin-dependent protein catabolic process
E0010212biological_processresponse to ionizing radiation
E0016567biological_processprotein ubiquitination
E0016607cellular_componentnuclear speck
E0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
E0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0045717biological_processnegative regulation of fatty acid biosynthetic process
E0061630molecular_functionubiquitin protein ligase activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0016567biological_processprotein ubiquitination
R0031461cellular_componentcullin-RING ubiquitin ligase complex
R0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
R0031625molecular_functionubiquitin protein ligase binding
R0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
R0044877molecular_functionprotein-containing complex binding
R0065003biological_processprotein-containing complex assembly
R0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
R1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
S0000109cellular_componentnucleotide-excision repair complex
S0000781cellular_componentchromosome, telomeric region
S0003677molecular_functionDNA binding
S0003684molecular_functiondamaged DNA binding
S0005515molecular_functionprotein binding
S0005576cellular_componentextracellular region
S0005634cellular_componentnucleus
S0005654cellular_componentnucleoplasm
S0005730cellular_componentnucleolus
S0005737cellular_componentcytoplasm
S0006281biological_processDNA repair
S0006289biological_processnucleotide-excision repair
S0006511biological_processubiquitin-dependent protein catabolic process
S0006974biological_processDNA damage response
S0007056biological_processspindle assembly involved in female meiosis
S0007283biological_processspermatogenesis
S0008283biological_processcell population proliferation
S0010498biological_processproteasomal protein catabolic process
S0010506biological_processregulation of autophagy
S0016567biological_processprotein ubiquitination
S0019076biological_processviral release from host cell
S0030174biological_processregulation of DNA-templated DNA replication initiation
S0030674molecular_functionprotein-macromolecule adaptor activity
S0031297biological_processreplication fork processing
S0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
S0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
S0032814biological_processregulation of natural killer cell activation
S0032991cellular_componentprotein-containing complex
S0034644biological_processcellular response to UV
S0035861cellular_componentsite of double-strand break
S0040029biological_processepigenetic regulation of gene expression
S0042127biological_processregulation of cell population proliferation
S0042752biological_processregulation of circadian rhythm
S0042981biological_processregulation of apoptotic process
S0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
S0044725biological_processepigenetic programming in the zygotic pronuclei
S0044877molecular_functionprotein-containing complex binding
S0045070biological_processpositive regulation of viral genome replication
S0045722biological_processpositive regulation of gluconeogenesis
S0045732biological_processpositive regulation of protein catabolic process
S0045995biological_processregulation of embryonic development
S0046726biological_processpositive regulation by virus of viral protein levels in host cell
S0051702biological_processbiological process involved in interaction with symbiont
S0060964biological_processregulation of miRNA-mediated gene silencing
S0070062cellular_componentextracellular exosome
S0070914biological_processUV-damage excision repair
S0071987molecular_functionWD40-repeat domain binding
S0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
S0080135biological_processregulation of cellular response to stress
S0097602molecular_functioncullin family protein binding
S0160072molecular_functionubiquitin ligase complex scaffold activity
S1901987biological_processregulation of cell cycle phase transition
S1901990biological_processregulation of mitotic cell cycle phase transition
S1902412biological_processregulation of mitotic cytokinesis
S1904178biological_processnegative regulation of adipose tissue development
S2000036biological_processregulation of stem cell population maintenance
Functional Information from PROSITE/UniProt
site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CgHsFCykCI
ChainResidueDetails
ACYS151-ILE160
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. IVSAstDsQLKLWNV
ChainResidueDetails
AILE613-VAL627
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues39
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues80
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues76
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues78
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsRegion: {"description":"Interaction with TRIB1","evidences":[{"source":"PubMed","id":"27041596","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsSite: {"description":"Interaction with TRIB1","evidences":[{"source":"PubMed","id":"27041596","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues40
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues40
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues146
DetailsDomain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsActive site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2026-05-27

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