9LTP

Crystal structure of human RAB43 in GDP-AlF3 transition state complex with USP6NL TBC domain

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000045	biological_process	autophagosome assembly
B	0000139	cellular_component	Golgi membrane
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0006886	biological_process	intracellular protein transport
B	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
B	0007030	biological_process	Golgi organization
B	0012505	cellular_component	endomembrane system
B	0019068	biological_process	virion assembly
B	0030670	cellular_component	phagocytic vesicle membrane
B	0032588	cellular_component	trans-Golgi network membrane
B	0033106	cellular_component	cis-Golgi network membrane
B	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
B	0035526	biological_process	retrograde transport, plasma membrane to Golgi
B	0045335	cellular_component	phagocytic vesicle
B	0070062	cellular_component	extracellular exosome
B	0090382	biological_process	phagosome maturation
B	1903358	biological_process	regulation of Golgi organization
D	0000045	biological_process	autophagosome assembly
D	0000139	cellular_component	Golgi membrane
D	0003924	molecular_function	GTPase activity
D	0003925	molecular_function	G protein activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005794	cellular_component	Golgi apparatus
D	0006886	biological_process	intracellular protein transport
D	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
D	0007030	biological_process	Golgi organization
D	0012505	cellular_component	endomembrane system
D	0019068	biological_process	virion assembly
D	0030670	cellular_component	phagocytic vesicle membrane
D	0032588	cellular_component	trans-Golgi network membrane
D	0033106	cellular_component	cis-Golgi network membrane
D	0033116	cellular_component	endoplasmic reticulum-Golgi intermediate compartment membrane
D	0035526	biological_process	retrograde transport, plasma membrane to Golgi
D	0045335	cellular_component	phagocytic vesicle
D	0070062	cellular_component	extracellular exosome
D	0090382	biological_process	phagosome maturation
D	1903358	biological_process	regulation of Golgi organization

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	192
Details	Domain: {"description":"Rab-GAP TBC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00163","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00753","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00753","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human RAB43 in complex with GDP.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2HUP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8CG50","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by LRRK2","evidences":[{"source":"PubMed","id":"29125462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---