9LTP
Crystal structure of human RAB43 in GDP-AlF3 transition state complex with USP6NL TBC domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000045 | biological_process | autophagosome assembly |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| B | 0007030 | biological_process | Golgi organization |
| B | 0019068 | biological_process | virion assembly |
| B | 0030670 | cellular_component | phagocytic vesicle membrane |
| B | 0032588 | cellular_component | trans-Golgi network membrane |
| B | 0033106 | cellular_component | cis-Golgi network membrane |
| B | 0033116 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| B | 0035526 | biological_process | retrograde transport, plasma membrane to Golgi |
| B | 0045335 | cellular_component | phagocytic vesicle |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0090382 | biological_process | phagosome maturation |
| B | 1903358 | biological_process | regulation of Golgi organization |
| D | 0000045 | biological_process | autophagosome assembly |
| D | 0000139 | cellular_component | Golgi membrane |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0003925 | molecular_function | G protein activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005789 | cellular_component | endoplasmic reticulum membrane |
| D | 0005794 | cellular_component | Golgi apparatus |
| D | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| D | 0007030 | biological_process | Golgi organization |
| D | 0019068 | biological_process | virion assembly |
| D | 0030670 | cellular_component | phagocytic vesicle membrane |
| D | 0032588 | cellular_component | trans-Golgi network membrane |
| D | 0033106 | cellular_component | cis-Golgi network membrane |
| D | 0033116 | cellular_component | endoplasmic reticulum-Golgi intermediate compartment membrane |
| D | 0035526 | biological_process | retrograde transport, plasma membrane to Golgi |
| D | 0045335 | cellular_component | phagocytic vesicle |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0090382 | biological_process | phagosome maturation |
| D | 1903358 | biological_process | regulation of Golgi organization |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 192 |
| Details | Domain: {"description":"Rab-GAP TBC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00163","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00753","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 32 |
| Details | Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00753","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human RAB43 in complex with GDP.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2HUP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8CG50","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by LRRK2","evidences":[{"source":"PubMed","id":"29125462","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
