9LOV
LGP2:MDA5:dsRNA filament
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002753 | biological_process | cytoplasmic pattern recognition receptor signaling pathway |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0003725 | molecular_function | double-stranded RNA binding |
| A | 0003727 | molecular_function | single-stranded RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009615 | biological_process | response to virus |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0032480 | biological_process | negative regulation of type I interferon production |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| A | 0039534 | biological_process | negative regulation of MDA-5 signaling pathway |
| A | 0039536 | biological_process | negative regulation of RIG-I signaling pathway |
| A | 0045088 | biological_process | regulation of innate immune response |
| A | 0045824 | biological_process | negative regulation of innate immune response |
| A | 0140374 | biological_process | antiviral innate immune response |
| A | 1900245 | biological_process | positive regulation of MDA-5 signaling pathway |
| A | 1900246 | biological_process | positive regulation of RIG-I signaling pathway |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 177 |
| Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 528 |
| Details | Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 130 |
| Details | Domain: {"description":"RLR CTR","evidences":[{"source":"PROSITE-ProRule","id":"PRU01125","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 83 |
| Details | Region: {"description":"RNA-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 57 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Motif: {"description":"DECH box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01125","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by RIOK3","evidences":[{"source":"PubMed","id":"25865883","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
