9LGU

Crystal structure of Bcl-xL in complex with stapled HRK peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001836	biological_process	release of cytochrome c from mitochondria
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005743	cellular_component	mitochondrial inner membrane
A	0005759	cellular_component	mitochondrial matrix
A	0005783	cellular_component	endoplasmic reticulum
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006897	biological_process	endocytosis
A	0006915	biological_process	apoptotic process
A	0006950	biological_process	response to stress
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0008637	biological_process	apoptotic mitochondrial changes
A	0015267	molecular_function	channel activity
A	0016020	cellular_component	membrane
A	0019901	molecular_function	protein kinase binding
A	0030672	cellular_component	synaptic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031965	cellular_component	nuclear membrane
A	0031966	cellular_component	mitochondrial membrane
A	0032465	biological_process	regulation of cytokinesis
A	0034097	biological_process	response to cytokine
A	0042802	molecular_function	identical protein binding
A	0043065	biological_process	positive regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0046902	biological_process	regulation of mitochondrial membrane permeability
A	0051434	molecular_function	BH3 domain binding
A	0051607	biological_process	defense response to virus
A	0051707	biological_process	response to other organism
A	0051881	biological_process	regulation of mitochondrial membrane potential
A	0055085	biological_process	transmembrane transport
A	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
A	0097136	cellular_component	Bcl-2 family protein complex
A	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
A	1900118	biological_process	negative regulation of execution phase of apoptosis
A	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A	1902531	biological_process	regulation of intracellular signal transduction
A	1903077	biological_process	negative regulation of protein localization to plasma membrane
A	2001233	biological_process	regulation of apoptotic signaling pathway
A	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
A	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
C	0001836	biological_process	release of cytochrome c from mitochondria
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005743	cellular_component	mitochondrial inner membrane
C	0005759	cellular_component	mitochondrial matrix
C	0005783	cellular_component	endoplasmic reticulum
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0006897	biological_process	endocytosis
C	0006915	biological_process	apoptotic process
C	0006950	biological_process	response to stress
C	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
C	0008637	biological_process	apoptotic mitochondrial changes
C	0015267	molecular_function	channel activity
C	0016020	cellular_component	membrane
C	0019901	molecular_function	protein kinase binding
C	0030672	cellular_component	synaptic vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0031965	cellular_component	nuclear membrane
C	0031966	cellular_component	mitochondrial membrane
C	0032465	biological_process	regulation of cytokinesis
C	0034097	biological_process	response to cytokine
C	0042802	molecular_function	identical protein binding
C	0043065	biological_process	positive regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0046902	biological_process	regulation of mitochondrial membrane permeability
C	0051434	molecular_function	BH3 domain binding
C	0051607	biological_process	defense response to virus
C	0051707	biological_process	response to other organism
C	0051881	biological_process	regulation of mitochondrial membrane potential
C	0055085	biological_process	transmembrane transport
C	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
C	0097136	cellular_component	Bcl-2 family protein complex
C	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
C	1900118	biological_process	negative regulation of execution phase of apoptosis
C	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
C	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
C	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
C	1902531	biological_process	regulation of intracellular signal transduction
C	1903077	biological_process	negative regulation of protein localization to plasma membrane
C	2001233	biological_process	regulation of apoptotic signaling pathway
C	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
C	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
E	0001836	biological_process	release of cytochrome c from mitochondria
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005743	cellular_component	mitochondrial inner membrane
E	0005759	cellular_component	mitochondrial matrix
E	0005783	cellular_component	endoplasmic reticulum
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0006897	biological_process	endocytosis
E	0006915	biological_process	apoptotic process
E	0006950	biological_process	response to stress
E	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
E	0008637	biological_process	apoptotic mitochondrial changes
E	0015267	molecular_function	channel activity
E	0016020	cellular_component	membrane
E	0019901	molecular_function	protein kinase binding
E	0030672	cellular_component	synaptic vesicle membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0031965	cellular_component	nuclear membrane
E	0031966	cellular_component	mitochondrial membrane
E	0032465	biological_process	regulation of cytokinesis
E	0034097	biological_process	response to cytokine
E	0042802	molecular_function	identical protein binding
E	0043065	biological_process	positive regulation of apoptotic process
E	0043066	biological_process	negative regulation of apoptotic process
E	0046902	biological_process	regulation of mitochondrial membrane permeability
E	0051434	molecular_function	BH3 domain binding
E	0051607	biological_process	defense response to virus
E	0051707	biological_process	response to other organism
E	0051881	biological_process	regulation of mitochondrial membrane potential
E	0055085	biological_process	transmembrane transport
E	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
E	0097136	cellular_component	Bcl-2 family protein complex
E	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
E	1900118	biological_process	negative regulation of execution phase of apoptosis
E	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
E	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
E	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
E	1902531	biological_process	regulation of intracellular signal transduction
E	1903077	biological_process	negative regulation of protein localization to plasma membrane
E	2001233	biological_process	regulation of apoptotic signaling pathway
E	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
E	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
G	0001836	biological_process	release of cytochrome c from mitochondria
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0005743	cellular_component	mitochondrial inner membrane
G	0005759	cellular_component	mitochondrial matrix
G	0005783	cellular_component	endoplasmic reticulum
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0006897	biological_process	endocytosis
G	0006915	biological_process	apoptotic process
G	0006950	biological_process	response to stress
G	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
G	0008637	biological_process	apoptotic mitochondrial changes
G	0015267	molecular_function	channel activity
G	0016020	cellular_component	membrane
G	0019901	molecular_function	protein kinase binding
G	0030672	cellular_component	synaptic vesicle membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0031965	cellular_component	nuclear membrane
G	0031966	cellular_component	mitochondrial membrane
G	0032465	biological_process	regulation of cytokinesis
G	0034097	biological_process	response to cytokine
G	0042802	molecular_function	identical protein binding
G	0043065	biological_process	positive regulation of apoptotic process
G	0043066	biological_process	negative regulation of apoptotic process
G	0046902	biological_process	regulation of mitochondrial membrane permeability
G	0051434	molecular_function	BH3 domain binding
G	0051607	biological_process	defense response to virus
G	0051707	biological_process	response to other organism
G	0051881	biological_process	regulation of mitochondrial membrane potential
G	0055085	biological_process	transmembrane transport
G	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
G	0097136	cellular_component	Bcl-2 family protein complex
G	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
G	1900118	biological_process	negative regulation of execution phase of apoptosis
G	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
G	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
G	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
G	1902531	biological_process	regulation of intracellular signal transduction
G	1903077	biological_process	negative regulation of protein localization to plasma membrane
G	2001233	biological_process	regulation of apoptotic signaling pathway
G	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
G	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
I	0001836	biological_process	release of cytochrome c from mitochondria
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005741	cellular_component	mitochondrial outer membrane
I	0005743	cellular_component	mitochondrial inner membrane
I	0005759	cellular_component	mitochondrial matrix
I	0005783	cellular_component	endoplasmic reticulum
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0006897	biological_process	endocytosis
I	0006915	biological_process	apoptotic process
I	0006950	biological_process	response to stress
I	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
I	0008637	biological_process	apoptotic mitochondrial changes
I	0015267	molecular_function	channel activity
I	0016020	cellular_component	membrane
I	0019901	molecular_function	protein kinase binding
I	0030672	cellular_component	synaptic vesicle membrane
I	0031410	cellular_component	cytoplasmic vesicle
I	0031965	cellular_component	nuclear membrane
I	0031966	cellular_component	mitochondrial membrane
I	0032465	biological_process	regulation of cytokinesis
I	0034097	biological_process	response to cytokine
I	0042802	molecular_function	identical protein binding
I	0043065	biological_process	positive regulation of apoptotic process
I	0043066	biological_process	negative regulation of apoptotic process
I	0046902	biological_process	regulation of mitochondrial membrane permeability
I	0051434	molecular_function	BH3 domain binding
I	0051607	biological_process	defense response to virus
I	0051707	biological_process	response to other organism
I	0051881	biological_process	regulation of mitochondrial membrane potential
I	0055085	biological_process	transmembrane transport
I	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
I	0097136	cellular_component	Bcl-2 family protein complex
I	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
I	1900118	biological_process	negative regulation of execution phase of apoptosis
I	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
I	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
I	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
I	1902531	biological_process	regulation of intracellular signal transduction
I	1903077	biological_process	negative regulation of protein localization to plasma membrane
I	2001233	biological_process	regulation of apoptotic signaling pathway
I	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
I	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
K	0001836	biological_process	release of cytochrome c from mitochondria
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005741	cellular_component	mitochondrial outer membrane
K	0005743	cellular_component	mitochondrial inner membrane
K	0005759	cellular_component	mitochondrial matrix
K	0005783	cellular_component	endoplasmic reticulum
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0006897	biological_process	endocytosis
K	0006915	biological_process	apoptotic process
K	0006950	biological_process	response to stress
K	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
K	0008637	biological_process	apoptotic mitochondrial changes
K	0015267	molecular_function	channel activity
K	0016020	cellular_component	membrane
K	0019901	molecular_function	protein kinase binding
K	0030672	cellular_component	synaptic vesicle membrane
K	0031410	cellular_component	cytoplasmic vesicle
K	0031965	cellular_component	nuclear membrane
K	0031966	cellular_component	mitochondrial membrane
K	0032465	biological_process	regulation of cytokinesis
K	0034097	biological_process	response to cytokine
K	0042802	molecular_function	identical protein binding
K	0043065	biological_process	positive regulation of apoptotic process
K	0043066	biological_process	negative regulation of apoptotic process
K	0046902	biological_process	regulation of mitochondrial membrane permeability
K	0051434	molecular_function	BH3 domain binding
K	0051607	biological_process	defense response to virus
K	0051707	biological_process	response to other organism
K	0051881	biological_process	regulation of mitochondrial membrane potential
K	0055085	biological_process	transmembrane transport
K	0090201	biological_process	negative regulation of release of cytochrome c from mitochondria
K	0097136	cellular_component	Bcl-2 family protein complex
K	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
K	1900118	biological_process	negative regulation of execution phase of apoptosis
K	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
K	1902230	biological_process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
K	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
K	1902531	biological_process	regulation of intracellular signal transduction
K	1903077	biological_process	negative regulation of protein localization to plasma membrane
K	2001233	biological_process	regulation of apoptotic signaling pathway
K	2001240	biological_process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
K	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	19
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG

Chain	Residue	Details
A	LEU130-GLY148

---

site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV

Chain	Residue	Details
A	TRP181-VAL192

---

site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. LalrLKlLGDELHQR

Chain	Residue	Details
B	LEU33-ARG47
A	VAL86-ARG100

---

site_id	PS01260
Number of Residues	21
Details	BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW

Chain	Residue	Details
A	SER4-TRP24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	Motif: {"description":"BH4"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	84
Details	Motif: {"description":"BH3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	114
Details	Motif: {"description":"BH1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	90
Details	Motif: {"description":"BH2"}

Chain

Residue

Details

---