9KWL

hCES1A contently binding with compound F-3 at the catalytic pocket.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004771	molecular_function	sterol ester esterase activity
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006695	biological_process	cholesterol biosynthetic process
A	0008203	biological_process	cholesterol metabolic process
A	0009636	biological_process	response to toxic substance
A	0010875	biological_process	positive regulation of cholesterol efflux
A	0010887	biological_process	negative regulation of cholesterol storage
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0030855	biological_process	epithelial cell differentiation
A	0042632	biological_process	cholesterol homeostasis
A	0043691	biological_process	reverse cholesterol transport
A	0047374	molecular_function	methylumbelliferyl-acetate deacetylase activity
A	0051791	biological_process	medium-chain fatty acid metabolic process
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	0070857	biological_process	regulation of bile acid biosynthetic process
A	0071397	biological_process	cellular response to cholesterol
A	0071404	biological_process	cellular response to low-density lipoprotein particle stimulus
A	0090122	biological_process	cholesterol ester hydrolysis involved in cholesterol transport
A	0090205	biological_process	positive regulation of cholesterol metabolic process
A	0106435	molecular_function	carboxylesterase activity
A	0120188	biological_process	regulation of bile acid secretion

Functional Information from PROSITE/UniProt

site_id	PS00122
Number of Residues	16
Details	CARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGnpgsVtIfGeSAG

Chain	Residue	Details
A	PHE191-GLY206

---

site_id	PS00941
Number of Residues	11
Details	CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNIYtP

Chain	Residue	Details
A	GLU97-PRO107

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10039","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12022871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"12022871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12022871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---