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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9KUW

Cryo-EM structure of dimeric APJR and two Beta-arrestins complex with small molecules

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
Q0001525biological_processangiogenesis
Q0001568biological_processblood vessel development
Q0001570biological_processvasculogenesis
Q0001944biological_processvasculature development
Q0001947biological_processheart looping
Q0003171biological_processatrioventricular valve development
Q0003272biological_processendocardial cushion formation
Q0004930molecular_functionG protein-coupled receptor activity
Q0005515molecular_functionprotein binding
Q0005886cellular_componentplasma membrane
Q0007165biological_processsignal transduction
Q0007186biological_processG protein-coupled receptor signaling pathway
Q0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Q0007369biological_processgastrulation
Q0007507biological_processheart development
Q0007512biological_processadult heart development
Q0008528molecular_functionG protein-coupled peptide receptor activity
Q0010468biological_processregulation of gene expression
Q0010629biological_processnegative regulation of gene expression
Q0035886biological_processvascular associated smooth muscle cell differentiation
Q0035904biological_processaorta development
Q0038023molecular_functionsignaling receptor activity
Q0045766biological_processpositive regulation of angiogenesis
Q0050878biological_processregulation of body fluid levels
Q0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
Q0060182molecular_functionapelin receptor activity
Q0060183biological_processapelin receptor signaling pathway
Q0060412biological_processventricular septum morphogenesis
Q0060841biological_processvenous blood vessel development
Q0060976biological_processcoronary vasculature development
Q0140897molecular_functionmechanoreceptor activity
Q1903243biological_processnegative regulation of cardiac muscle hypertrophy in response to stress
Q1903244biological_processpositive regulation of cardiac muscle hypertrophy in response to stress
Q1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Q1903596biological_processregulation of gap junction assembly
Q1904022biological_processpositive regulation of G protein-coupled receptor internalization
R0001525biological_processangiogenesis
R0001568biological_processblood vessel development
R0001570biological_processvasculogenesis
R0001944biological_processvasculature development
R0001947biological_processheart looping
R0003171biological_processatrioventricular valve development
R0003272biological_processendocardial cushion formation
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0007165biological_processsignal transduction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R0007369biological_processgastrulation
R0007507biological_processheart development
R0007512biological_processadult heart development
R0008528molecular_functionG protein-coupled peptide receptor activity
R0010468biological_processregulation of gene expression
R0010629biological_processnegative regulation of gene expression
R0035886biological_processvascular associated smooth muscle cell differentiation
R0035904biological_processaorta development
R0038023molecular_functionsignaling receptor activity
R0045766biological_processpositive regulation of angiogenesis
R0050878biological_processregulation of body fluid levels
R0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
R0060182molecular_functionapelin receptor activity
R0060183biological_processapelin receptor signaling pathway
R0060412biological_processventricular septum morphogenesis
R0060841biological_processvenous blood vessel development
R0060976biological_processcoronary vasculature development
R0140897molecular_functionmechanoreceptor activity
R1903243biological_processnegative regulation of cardiac muscle hypertrophy in response to stress
R1903244biological_processpositive regulation of cardiac muscle hypertrophy in response to stress
R1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
R1903596biological_processregulation of gap junction assembly
R1904022biological_processpositive regulation of G protein-coupled receptor internalization
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVfCLTGLSFDRYLaI
ChainResidueDetails
QALA115-ILE131
site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
APHE61-LEU79
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues46
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues102
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues126
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues50
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues34
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues46
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7W0O","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsSite: {"description":"Required for APELA and APLN/apelin-13 interaction and signaling","evidences":[{"source":"PubMed","id":"35817871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38428423","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

250359

PDB entries from 2026-03-11

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