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9KRJ

Structure of mouse Dyrk1a

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000381biological_processregulation of alternative mRNA splicing, via spliceosome
A0000724biological_processdouble-strand break repair via homologous recombination
A0001933biological_processnegative regulation of protein phosphorylation
A0003713molecular_functiontranscription coactivator activity
A0003779molecular_functionactin binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005883cellular_componentneurofilament
A0005884cellular_componentactin filament
A0006303biological_processdouble-strand break repair via nonhomologous end joining
A0006338biological_processchromatin remodeling
A0006351biological_processDNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0006606biological_processprotein import into nucleus
A0007623biological_processcircadian rhythm
A0008092molecular_functioncytoskeletal protein binding
A0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
A0010629biological_processnegative regulation of gene expression
A0015631molecular_functiontubulin binding
A0016301molecular_functionkinase activity
A0016607cellular_componentnuclear speck
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0018108biological_processpeptidyl-tyrosine phosphorylation
A0030332molecular_functioncyclin binding
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031115biological_processnegative regulation of microtubule polymerization
A0031452biological_processnegative regulation of heterochromatin formation
A0033120biological_processpositive regulation of RNA splicing
A0033173biological_processcalcineurin-NFAT signaling cascade
A0042802molecular_functionidentical protein binding
A0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
A0045786biological_processnegative regulation of cell cycle
A0045893biological_processpositive regulation of DNA-templated transcription
A0046777biological_processprotein autophosphorylation
A0048025biological_processnegative regulation of mRNA splicing, via spliceosome
A0048156molecular_functiontau protein binding
A0060043biological_processregulation of cardiac muscle cell proliferation
A0061050biological_processregulation of cell growth involved in cardiac muscle cell development
A0106310molecular_functionprotein serine kinase activity
A0140857molecular_functionhistone H3T45 kinase activity
A1902003biological_processregulation of amyloid-beta formation
A1902996biological_processregulation of neurofibrillary tangle assembly
A1990904cellular_componentribonucleoprotein complex
A1990935molecular_functionsplicing factor binding
A2000781biological_processpositive regulation of double-strand break repair
B0000166molecular_functionnucleotide binding
B0000381biological_processregulation of alternative mRNA splicing, via spliceosome
B0000724biological_processdouble-strand break repair via homologous recombination
B0001933biological_processnegative regulation of protein phosphorylation
B0003713molecular_functiontranscription coactivator activity
B0003779molecular_functionactin binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0005883cellular_componentneurofilament
B0005884cellular_componentactin filament
B0006303biological_processdouble-strand break repair via nonhomologous end joining
B0006338biological_processchromatin remodeling
B0006351biological_processDNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0006606biological_processprotein import into nucleus
B0007623biological_processcircadian rhythm
B0008092molecular_functioncytoskeletal protein binding
B0008353molecular_functionRNA polymerase II CTD heptapeptide repeat kinase activity
B0010629biological_processnegative regulation of gene expression
B0015631molecular_functiontubulin binding
B0016301molecular_functionkinase activity
B0016607cellular_componentnuclear speck
B0016740molecular_functiontransferase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0018108biological_processpeptidyl-tyrosine phosphorylation
B0030332molecular_functioncyclin binding
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0031115biological_processnegative regulation of microtubule polymerization
B0031452biological_processnegative regulation of heterochromatin formation
B0033120biological_processpositive regulation of RNA splicing
B0033173biological_processcalcineurin-NFAT signaling cascade
B0042802molecular_functionidentical protein binding
B0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
B0045786biological_processnegative regulation of cell cycle
B0045893biological_processpositive regulation of DNA-templated transcription
B0046777biological_processprotein autophosphorylation
B0048025biological_processnegative regulation of mRNA splicing, via spliceosome
B0048156molecular_functiontau protein binding
B0060043biological_processregulation of cardiac muscle cell proliferation
B0061050biological_processregulation of cell growth involved in cardiac muscle cell development
B0106310molecular_functionprotein serine kinase activity
B0140857molecular_functionhistone H3T45 kinase activity
B1902003biological_processregulation of amyloid-beta formation
B1902996biological_processregulation of neurofibrillary tangle assembly
B1990904cellular_componentribonucleoprotein complex
B1990935molecular_functionsplicing factor binding
B2000781biological_processpositive regulation of double-strand break repair
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGSFGQVVkAydrveqew..........VAIK
ChainResidueDetails
AILE165-LYS188

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHcDLKpeNILL
ChainResidueDetails
AILE283-LEU295

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues12
DetailsModified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q13627","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18034455","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q63470","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q13627","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q13627","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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