9KP6

Cryo-EM structure of mouse bestrophin-1 in a closed state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005229	molecular_function	intracellularly calcium-gated chloride channel activity
A	0005254	molecular_function	chloride channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0009925	cellular_component	basal plasma membrane
A	0014047	biological_process	glutamate secretion
A	0015267	molecular_function	channel activity
A	0015701	biological_process	bicarbonate transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0022834	molecular_function	ligand-gated channel activity
A	0030321	biological_process	transepithelial chloride transport
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034707	cellular_component	chloride channel complex
A	0042597	cellular_component	periplasmic space
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0048167	biological_process	regulation of synaptic plasticity
A	0050908	biological_process	detection of light stimulus involved in visual perception
A	0051259	biological_process	protein complex oligomerization
A	0051924	biological_process	regulation of calcium ion transport
A	0061534	biological_process	gamma-aminobutyric acid secretion, neurotransmission
A	0098793	cellular_component	presynapse
A	0098857	cellular_component	membrane microdomain
A	0160133	molecular_function	bicarbonate channel activity
A	1902476	biological_process	chloride transmembrane transport
B	0005229	molecular_function	intracellularly calcium-gated chloride channel activity
B	0005254	molecular_function	chloride channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006821	biological_process	chloride transport
B	0009925	cellular_component	basal plasma membrane
B	0014047	biological_process	glutamate secretion
B	0015267	molecular_function	channel activity
B	0015701	biological_process	bicarbonate transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0022834	molecular_function	ligand-gated channel activity
B	0030321	biological_process	transepithelial chloride transport
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034707	cellular_component	chloride channel complex
B	0042597	cellular_component	periplasmic space
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0048167	biological_process	regulation of synaptic plasticity
B	0050908	biological_process	detection of light stimulus involved in visual perception
B	0051259	biological_process	protein complex oligomerization
B	0051924	biological_process	regulation of calcium ion transport
B	0061534	biological_process	gamma-aminobutyric acid secretion, neurotransmission
B	0098793	cellular_component	presynapse
B	0098857	cellular_component	membrane microdomain
B	0160133	molecular_function	bicarbonate channel activity
B	1902476	biological_process	chloride transmembrane transport
C	0005229	molecular_function	intracellularly calcium-gated chloride channel activity
C	0005254	molecular_function	chloride channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006821	biological_process	chloride transport
C	0009925	cellular_component	basal plasma membrane
C	0014047	biological_process	glutamate secretion
C	0015267	molecular_function	channel activity
C	0015701	biological_process	bicarbonate transport
C	0016020	cellular_component	membrane
C	0016323	cellular_component	basolateral plasma membrane
C	0022834	molecular_function	ligand-gated channel activity
C	0030321	biological_process	transepithelial chloride transport
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034707	cellular_component	chloride channel complex
C	0042597	cellular_component	periplasmic space
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0048167	biological_process	regulation of synaptic plasticity
C	0050908	biological_process	detection of light stimulus involved in visual perception
C	0051259	biological_process	protein complex oligomerization
C	0051924	biological_process	regulation of calcium ion transport
C	0061534	biological_process	gamma-aminobutyric acid secretion, neurotransmission
C	0098793	cellular_component	presynapse
C	0098857	cellular_component	membrane microdomain
C	0160133	molecular_function	bicarbonate channel activity
C	1902476	biological_process	chloride transmembrane transport
D	0005229	molecular_function	intracellularly calcium-gated chloride channel activity
D	0005254	molecular_function	chloride channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006821	biological_process	chloride transport
D	0009925	cellular_component	basal plasma membrane
D	0014047	biological_process	glutamate secretion
D	0015267	molecular_function	channel activity
D	0015701	biological_process	bicarbonate transport
D	0016020	cellular_component	membrane
D	0016323	cellular_component	basolateral plasma membrane
D	0022834	molecular_function	ligand-gated channel activity
D	0030321	biological_process	transepithelial chloride transport
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034707	cellular_component	chloride channel complex
D	0042597	cellular_component	periplasmic space
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0048167	biological_process	regulation of synaptic plasticity
D	0050908	biological_process	detection of light stimulus involved in visual perception
D	0051259	biological_process	protein complex oligomerization
D	0051924	biological_process	regulation of calcium ion transport
D	0061534	biological_process	gamma-aminobutyric acid secretion, neurotransmission
D	0098793	cellular_component	presynapse
D	0098857	cellular_component	membrane microdomain
D	0160133	molecular_function	bicarbonate channel activity
D	1902476	biological_process	chloride transmembrane transport
E	0005229	molecular_function	intracellularly calcium-gated chloride channel activity
E	0005254	molecular_function	chloride channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006821	biological_process	chloride transport
E	0009925	cellular_component	basal plasma membrane
E	0014047	biological_process	glutamate secretion
E	0015267	molecular_function	channel activity
E	0015701	biological_process	bicarbonate transport
E	0016020	cellular_component	membrane
E	0016323	cellular_component	basolateral plasma membrane
E	0022834	molecular_function	ligand-gated channel activity
E	0030321	biological_process	transepithelial chloride transport
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034707	cellular_component	chloride channel complex
E	0042597	cellular_component	periplasmic space
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0048167	biological_process	regulation of synaptic plasticity
E	0050908	biological_process	detection of light stimulus involved in visual perception
E	0051259	biological_process	protein complex oligomerization
E	0051924	biological_process	regulation of calcium ion transport
E	0061534	biological_process	gamma-aminobutyric acid secretion, neurotransmission
E	0098793	cellular_component	presynapse
E	0098857	cellular_component	membrane microdomain
E	0160133	molecular_function	bicarbonate channel activity
E	1902476	biological_process	chloride transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	350
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"O76090","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	130
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"O76090","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	770
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"O76090","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"O76090","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O76090","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---