Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9KHI

Cryo-EM structure of heteromeric TRPC channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005102	molecular_function	signaling receptor binding
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0015279	molecular_function	store-operated calcium channel activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034703	cellular_component	cation channel complex
A	0042438	biological_process	melanin biosynthetic process
A	0043235	cellular_component	receptor complex
A	0046872	molecular_function	metal ion binding
A	0051117	molecular_function	ATPase binding
A	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
A	0051480	biological_process	regulation of cytosolic calcium ion concentration
A	0051592	biological_process	response to calcium ion
A	0070588	biological_process	calcium ion transmembrane transport
A	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
A	1903779	biological_process	regulation of cardiac conduction

Functional Information from PROSITE/UniProt

site_id	PS00962
Number of Residues	12
Details	RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. LiSLFTANSHLG

Chain	Residue	Details
D	LEU493-GLY504

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	Intramembrane: {"description":"Discontinuously helical; Name=Pre-S1","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	39
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	17
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	20
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39478185","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8WPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8WPM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	102
Details	Intramembrane: {"description":"Discontinuously helical; Name=Pre-S1","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	87
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	321
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	66
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	84
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	87
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37137991","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7X6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)