Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9KGL

Structure of KATP channel in complex with centipede toxin SpTx1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005242	molecular_function	inward rectifier potassium channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006006	biological_process	glucose metabolic process
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008282	cellular_component	inward rectifying potassium channel
A	0009410	biological_process	response to xenobiotic stimulus
A	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
A	0016020	cellular_component	membrane
A	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
A	0030315	cellular_component	T-tubule
A	0030506	molecular_function	ankyrin binding
A	0030955	molecular_function	potassium ion binding
A	0032991	cellular_component	protein-containing complex
A	0033198	biological_process	response to ATP
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0042391	biological_process	regulation of membrane potential
A	0044325	molecular_function	transmembrane transporter binding
A	0046676	biological_process	negative regulation of insulin secretion
A	0046872	molecular_function	metal ion binding
A	0050796	biological_process	regulation of insulin secretion
A	0050877	biological_process	nervous system process
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
A	0098659	biological_process	inorganic cation import across plasma membrane
A	0099505	biological_process	regulation of presynaptic membrane potential
A	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A	1990573	biological_process	potassium ion import across plasma membrane
B	0000166	molecular_function	nucleotide binding
B	0005267	molecular_function	potassium channel activity
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0008282	cellular_component	inward rectifying potassium channel
B	0009410	biological_process	response to xenobiotic stimulus
B	0016020	cellular_component	membrane
B	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
B	0032991	cellular_component	protein-containing complex
B	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
B	0042383	cellular_component	sarcolemma
B	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
B	0043531	molecular_function	ADP binding
B	0044325	molecular_function	transmembrane transporter binding
B	0046676	biological_process	negative regulation of insulin secretion
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0071805	biological_process	potassium ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0005242	molecular_function	inward rectifier potassium channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006006	biological_process	glucose metabolic process
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0008282	cellular_component	inward rectifying potassium channel
C	0009410	biological_process	response to xenobiotic stimulus
C	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
C	0016020	cellular_component	membrane
C	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
C	0030315	cellular_component	T-tubule
C	0030506	molecular_function	ankyrin binding
C	0030955	molecular_function	potassium ion binding
C	0032991	cellular_component	protein-containing complex
C	0033198	biological_process	response to ATP
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0042391	biological_process	regulation of membrane potential
C	0044325	molecular_function	transmembrane transporter binding
C	0046676	biological_process	negative regulation of insulin secretion
C	0046872	molecular_function	metal ion binding
C	0050796	biological_process	regulation of insulin secretion
C	0050877	biological_process	nervous system process
C	0055085	biological_process	transmembrane transport
C	0071805	biological_process	potassium ion transmembrane transport
C	0098659	biological_process	inorganic cation import across plasma membrane
C	0099505	biological_process	regulation of presynaptic membrane potential
C	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C	1990573	biological_process	potassium ion import across plasma membrane
D	0000166	molecular_function	nucleotide binding
D	0005267	molecular_function	potassium channel activity
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0008282	cellular_component	inward rectifying potassium channel
D	0009410	biological_process	response to xenobiotic stimulus
D	0016020	cellular_component	membrane
D	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
D	0032991	cellular_component	protein-containing complex
D	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
D	0042383	cellular_component	sarcolemma
D	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
D	0043531	molecular_function	ADP binding
D	0044325	molecular_function	transmembrane transporter binding
D	0046676	biological_process	negative regulation of insulin secretion
D	0046872	molecular_function	metal ion binding
D	0055085	biological_process	transmembrane transport
D	0071805	biological_process	potassium ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport
E	0000166	molecular_function	nucleotide binding
E	0005242	molecular_function	inward rectifier potassium channel activity
E	0005249	molecular_function	voltage-gated potassium channel activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0006006	biological_process	glucose metabolic process
E	0006811	biological_process	monoatomic ion transport
E	0006813	biological_process	potassium ion transport
E	0008282	cellular_component	inward rectifying potassium channel
E	0009410	biological_process	response to xenobiotic stimulus
E	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
E	0016020	cellular_component	membrane
E	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
E	0030315	cellular_component	T-tubule
E	0030506	molecular_function	ankyrin binding
E	0030955	molecular_function	potassium ion binding
E	0032991	cellular_component	protein-containing complex
E	0033198	biological_process	response to ATP
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034702	cellular_component	monoatomic ion channel complex
E	0042391	biological_process	regulation of membrane potential
E	0044325	molecular_function	transmembrane transporter binding
E	0046676	biological_process	negative regulation of insulin secretion
E	0046872	molecular_function	metal ion binding
E	0050796	biological_process	regulation of insulin secretion
E	0050877	biological_process	nervous system process
E	0055085	biological_process	transmembrane transport
E	0071805	biological_process	potassium ion transmembrane transport
E	0098659	biological_process	inorganic cation import across plasma membrane
E	0099505	biological_process	regulation of presynaptic membrane potential
E	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
E	1990573	biological_process	potassium ion import across plasma membrane
F	0000166	molecular_function	nucleotide binding
F	0005267	molecular_function	potassium channel activity
F	0005524	molecular_function	ATP binding
F	0005886	cellular_component	plasma membrane
F	0008282	cellular_component	inward rectifying potassium channel
F	0009410	biological_process	response to xenobiotic stimulus
F	0016020	cellular_component	membrane
F	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
F	0032991	cellular_component	protein-containing complex
F	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
F	0042383	cellular_component	sarcolemma
F	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
F	0043531	molecular_function	ADP binding
F	0044325	molecular_function	transmembrane transporter binding
F	0046676	biological_process	negative regulation of insulin secretion
F	0046872	molecular_function	metal ion binding
F	0055085	biological_process	transmembrane transport
F	0071805	biological_process	potassium ion transmembrane transport
F	0098655	biological_process	monoatomic cation transmembrane transport
G	0000166	molecular_function	nucleotide binding
G	0005242	molecular_function	inward rectifier potassium channel activity
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005886	cellular_component	plasma membrane
G	0006006	biological_process	glucose metabolic process
G	0006811	biological_process	monoatomic ion transport
G	0006813	biological_process	potassium ion transport
G	0008282	cellular_component	inward rectifying potassium channel
G	0009410	biological_process	response to xenobiotic stimulus
G	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
G	0016020	cellular_component	membrane
G	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
G	0030315	cellular_component	T-tubule
G	0030506	molecular_function	ankyrin binding
G	0030955	molecular_function	potassium ion binding
G	0032991	cellular_component	protein-containing complex
G	0033198	biological_process	response to ATP
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0034702	cellular_component	monoatomic ion channel complex
G	0042391	biological_process	regulation of membrane potential
G	0044325	molecular_function	transmembrane transporter binding
G	0046676	biological_process	negative regulation of insulin secretion
G	0046872	molecular_function	metal ion binding
G	0050796	biological_process	regulation of insulin secretion
G	0050877	biological_process	nervous system process
G	0055085	biological_process	transmembrane transport
G	0071805	biological_process	potassium ion transmembrane transport
G	0098659	biological_process	inorganic cation import across plasma membrane
G	0099505	biological_process	regulation of presynaptic membrane potential
G	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
G	1990573	biological_process	potassium ion import across plasma membrane
H	0000166	molecular_function	nucleotide binding
H	0005267	molecular_function	potassium channel activity
H	0005524	molecular_function	ATP binding
H	0005886	cellular_component	plasma membrane
H	0008282	cellular_component	inward rectifying potassium channel
H	0009410	biological_process	response to xenobiotic stimulus
H	0016020	cellular_component	membrane
H	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
H	0032991	cellular_component	protein-containing complex
H	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
H	0042383	cellular_component	sarcolemma
H	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
H	0043531	molecular_function	ADP binding
H	0044325	molecular_function	transmembrane transporter binding
H	0046676	biological_process	negative regulation of insulin secretion
H	0046872	molecular_function	metal ion binding
H	0055085	biological_process	transmembrane transport
H	0071805	biological_process	potassium ion transmembrane transport
H	0098655	biological_process	monoatomic cation transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL

Chain	Residue	Details
B	LEU830-LEU844
B	PHE1482-PHE1496

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	104
Details	Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	124
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	64
Details	Intramembrane: {"description":"Discontinuously helical; Pore-forming","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P70673","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by MAPK1","evidences":[{"source":"PubMed","id":"18280666","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)