9KDG

CryoEM structure of Calcineurin-fusion Human endothelin receptor type-B in the ligand-free form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005509	molecular_function	calcium ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0033192	molecular_function	calmodulin-dependent protein phosphatase activity
A	0097720	biological_process	calcineurin-mediated signaling
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0005102	molecular_function	signaling receptor binding
F	0005246	molecular_function	calcium channel regulator activity
F	0005515	molecular_function	protein binding
F	0005528	molecular_function	FK506 binding
F	0005737	cellular_component	cytoplasm
F	0006457	biological_process	protein folding
F	0006458	biological_process	'de novo' protein folding
F	0010459	biological_process	negative regulation of heart rate
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0016529	cellular_component	sarcoplasmic reticulum
F	0019722	biological_process	calcium-mediated signaling
F	0019855	molecular_function	calcium channel inhibitor activity
F	0030018	cellular_component	Z disc
F	0033017	cellular_component	sarcoplasmic reticulum membrane
F	0034704	cellular_component	calcium channel complex
F	0042026	biological_process	protein refolding
F	0044325	molecular_function	transmembrane transporter binding
F	0050849	biological_process	negative regulation of calcium-mediated signaling
F	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
F	0051604	biological_process	protein maturation
F	0051775	biological_process	response to redox state

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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