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9KDG

CryoEM structure of Calcineurin-fusion Human endothelin receptor type-B in the ligand-free form

Functional Information from GO Data
ChainGOidnamespacecontents
A0004930molecular_functionG protein-coupled receptor activity
A0005509molecular_functioncalcium ion binding
A0007186biological_processG protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0033192molecular_functioncalmodulin-dependent protein phosphatase activity
A0097720biological_processcalcineurin-mediated signaling
F0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
F0005102molecular_functionsignaling receptor binding
F0005246molecular_functioncalcium channel regulator activity
F0005515molecular_functionprotein binding
F0005528molecular_functionFK506 binding
F0005737cellular_componentcytoplasm
F0006457biological_processprotein folding
F0006458biological_process'de novo' protein folding
F0010459biological_processnegative regulation of heart rate
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016529cellular_componentsarcoplasmic reticulum
F0016853molecular_functionisomerase activity
F0019722biological_processcalcium-mediated signaling
F0019855molecular_functioncalcium channel inhibitor activity
F0030018cellular_componentZ disc
F0033017cellular_componentsarcoplasmic reticulum membrane
F0034704cellular_componentcalcium channel complex
F0042026biological_processprotein refolding
F0044325molecular_functiontransmembrane transporter binding
F0050849biological_processnegative regulation of calcium-mediated signaling
F0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
F0051604biological_processprotein maturation
F0051775biological_processresponse to redox state
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DLDNSGSLSveEF
ChainResidueDetails
AASP320-PHE332
AASP352-PHE364
AASP389-LEU401
AASP430-PHE442

site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
ALEU1132-GLU1137

site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ITVlSLCALSIDRYRaV
ChainResidueDetails
AILE187-VAL203

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues88
DetailsDomain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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