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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9K1R

Structure of SF3B core in complex with the intron-U2 snRNA (SF3B-intron-U2 snRNA)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000124cellular_componentSAGA complex
A0000375biological_processRNA splicing, via transesterification reactions
A0000398biological_processmRNA splicing, via spliceosome
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005681cellular_componentspliceosomal complex
A0005684cellular_componentU2-type spliceosomal complex
A0005686cellular_componentU2 snRNP
A0005689cellular_componentU12-type spliceosomal complex
A0005730cellular_componentnucleolus
A0006282biological_processregulation of DNA repair
A0006397biological_processmRNA processing
A0008380biological_processRNA splicing
A0030620molecular_functionU2 snRNA binding
A0042177biological_processnegative regulation of protein catabolic process
A0043484biological_processregulation of RNA splicing
A0044877molecular_functionprotein-containing complex binding
A0045893biological_processpositive regulation of DNA-templated transcription
A0071005cellular_componentU2-type precatalytic spliceosome
A0071013cellular_componentcatalytic step 2 spliceosome
A1903241biological_processU2-type prespliceosome assembly
B0000124cellular_componentSAGA complex
B0000398biological_processmRNA splicing, via spliceosome
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005681cellular_componentspliceosomal complex
B0005684cellular_componentU2-type spliceosomal complex
B0005686cellular_componentU2 snRNP
B0005689cellular_componentU12-type spliceosomal complex
B0006282biological_processregulation of DNA repair
B0006397biological_processmRNA processing
B0008380biological_processRNA splicing
B0043484biological_processregulation of RNA splicing
B0045893biological_processpositive regulation of DNA-templated transcription
B0071005cellular_componentU2-type precatalytic spliceosome
B0071011cellular_componentprecatalytic spliceosome
B1903241biological_processU2-type prespliceosome assembly
B1990935molecular_functionsplicing factor binding
D0000398biological_processmRNA splicing, via spliceosome
D0003677molecular_functionDNA binding
D0003723molecular_functionRNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005681cellular_componentspliceosomal complex
D0005684cellular_componentU2-type spliceosomal complex
D0005686cellular_componentU2 snRNP
D0005689cellular_componentU12-type spliceosomal complex
D0006397biological_processmRNA processing
D0008270molecular_functionzinc ion binding
D0008380biological_processRNA splicing
D0016363cellular_componentnuclear matrix
D0016607cellular_componentnuclear speck
D0045893biological_processpositive regulation of DNA-templated transcription
D0046872molecular_functionmetal ion binding
D0048863biological_processstem cell differentiation
D0071005cellular_componentU2-type precatalytic spliceosome
D0071011cellular_componentprecatalytic spliceosome
D1903241biological_processU2-type prespliceosome assembly
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FVCSATH
ChainResidueDetails
APHE287-HIS293
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues39
DetailsRepeat: {"description":"HEAT 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues34
DetailsRepeat: {"description":"HEAT 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues37
DetailsRepeat: {"description":"HEAT 3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues34
DetailsRepeat: {"description":"HEAT 4"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues38
DetailsRepeat: {"description":"HEAT 5"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues38
DetailsRepeat: {"description":"HEAT 6"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues38
DetailsRepeat: {"description":"HEAT 7"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues38
DetailsRepeat: {"description":"HEAT 8"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues38
DetailsRepeat: {"description":"HEAT 9"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues38
DetailsRepeat: {"description":"HEAT 10"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues38
DetailsRepeat: {"description":"HEAT 11"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues39
DetailsRegion: {"description":"Interaction with SF3B14"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsRegion: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues56
DetailsRegion: {"description":"Interaction with SF3B3 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues6
DetailsSite: {"description":"Interaction with RNA","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsSite: {"description":"Interaction with PHF5A","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsSite: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues77
DetailsRegion: {"description":"Interaction with SF3B1 and SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues3
DetailsRegion: {"description":"Interaction with SF3B3","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"28541300","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IFE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SYB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P83870","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues37
DetailsRegion: {"description":"Interaction with PHF5A, SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues56
DetailsRegion: {"description":"Interaction with SF3B1 and SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues21
DetailsRegion: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues23
DetailsRegion: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues5
DetailsSite: {"description":"Interaction with SF3B5","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues2
DetailsSite: {"description":"Interaction with SF3B1","evidences":[{"source":"PubMed","id":"27720643","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-10-29

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