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9JKB

Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO4 SCF ubiquition ligase complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006355biological_processregulation of DNA-templated transcription
A0006511biological_processubiquitin-dependent protein catabolic process
A0006879biological_processintracellular iron ion homeostasis
A0007346biological_processregulation of mitotic cell cycle
A0010564biological_processregulation of cell cycle process
A0010824biological_processregulation of centrosome duplication
A0014033biological_processneural crest cell differentiation
A0016567biological_processprotein ubiquitination
A0019005cellular_componentSCF ubiquitin ligase complex
A0030510biological_processregulation of BMP signaling pathway
A0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
A0031461cellular_componentcullin-RING ubiquitin ligase complex
A0031625molecular_functionubiquitin protein ligase binding
A0032006biological_processregulation of TOR signaling
A0034599biological_processcellular response to oxidative stress
A0042752biological_processregulation of circadian rhythm
A0042981biological_processregulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0050727biological_processregulation of inflammatory response
A0051298biological_processcentrosome duplication
A0051726biological_processregulation of cell cycle
A0060173biological_processlimb development
A0060271biological_processcilium assembly
A0070936biological_processprotein K48-linked ubiquitination
A0097193biological_processintrinsic apoptotic signaling pathway
A0160072molecular_functionubiquitin ligase complex scaffold activity
A1901524biological_processregulation of mitophagy
A1904415biological_processregulation of xenophagy
A1990452cellular_componentParkin-FBXW7-Cul1 ubiquitin ligase complex
A2000001biological_processregulation of DNA damage checkpoint
B0000082biological_processG1/S transition of mitotic cell cycle
B0000209biological_processprotein polyubiquitination
B0000785cellular_componentchromatin
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0006338biological_processchromatin remodeling
B0006355biological_processregulation of DNA-templated transcription
B0006511biological_processubiquitin-dependent protein catabolic process
B0006879biological_processintracellular iron ion homeostasis
B0007346biological_processregulation of mitotic cell cycle
B0008013molecular_functionbeta-catenin binding
B0010564biological_processregulation of cell cycle process
B0010824biological_processregulation of centrosome duplication
B0014033biological_processneural crest cell differentiation
B0016567biological_processprotein ubiquitination
B0019005cellular_componentSCF ubiquitin ligase complex
B0019904molecular_functionprotein domain specific binding
B0030510biological_processregulation of BMP signaling pathway
B0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
B0031467cellular_componentCul7-RING ubiquitin ligase complex
B0031507biological_processheterochromatin formation
B0031519cellular_componentPcG protein complex
B0032006biological_processregulation of TOR signaling
B0042752biological_processregulation of circadian rhythm
B0042981biological_processregulation of apoptotic process
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045892biological_processnegative regulation of DNA-templated transcription
B0050727biological_processregulation of inflammatory response
B0051124biological_processsynaptic assembly at neuromuscular junction
B0051298biological_processcentrosome duplication
B0051457biological_processmaintenance of protein location in nucleus
B0051726biological_processregulation of cell cycle
B0060173biological_processlimb development
B0060271biological_processcilium assembly
B0070936biological_processprotein K48-linked ubiquitination
B0097602molecular_functioncullin family protein binding
B0140677molecular_functionmolecular function activator activity
B0160072molecular_functionubiquitin ligase complex scaffold activity
B1901524biological_processregulation of mitophagy
B1904415biological_processregulation of xenophagy
B1990444molecular_functionF-box domain binding
B1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
B1990757molecular_functionubiquitin ligase activator activity
B2000001biological_processregulation of DNA damage checkpoint
C0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D0031146biological_processSCF-dependent proteasomal ubiquitin-dependent protein catabolic process
R0008270molecular_functionzinc ion binding
Functional Information from PROSITE/UniProt
site_idPS01256
Number of Residues28
DetailsCULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA
ChainResidueDetails
AILE749-ALA776

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues46
DetailsDomain: {"description":"F-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00080","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues60
DetailsDomain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"PubMed","id":"10597293","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15537541","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18805092","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues20
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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