9J0O

Arrested elongation complex of mammalian RNA polymerase II with nucleosome (AEC1-nuc)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000428	cellular_component	DNA-directed RNA polymerase complex
B	0003677	molecular_function	DNA binding
B	0003899	molecular_function	DNA-directed RNA polymerase activity
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0006351	biological_process	DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0016787	molecular_function	hydrolase activity
B	0032549	molecular_function	ribonucleoside binding
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0046872	molecular_function	metal ion binding
C	0000428	cellular_component	DNA-directed RNA polymerase complex
C	0003677	molecular_function	DNA binding
C	0003899	molecular_function	DNA-directed RNA polymerase activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005665	cellular_component	RNA polymerase II, core complex
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006366	biological_process	transcription by RNA polymerase II
C	0046983	molecular_function	protein dimerization activity
D	0000166	molecular_function	nucleotide binding
D	0000428	cellular_component	DNA-directed RNA polymerase complex
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0006352	biological_process	DNA-templated transcription initiation
D	0030880	cellular_component	RNA polymerase complex
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003677	molecular_function	DNA binding
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005665	cellular_component	RNA polymerase II, core complex
E	0005666	cellular_component	RNA polymerase III complex
E	0005736	cellular_component	RNA polymerase I complex
E	0006351	biological_process	DNA-templated transcription
E	0006362	biological_process	transcription elongation by RNA polymerase I
E	0006366	biological_process	transcription by RNA polymerase II
E	0042797	biological_process	tRNA transcription by RNA polymerase III
F	0000428	cellular_component	DNA-directed RNA polymerase complex
F	0001650	cellular_component	fibrillar center
F	0003677	molecular_function	DNA binding
F	0003899	molecular_function	DNA-directed RNA polymerase activity
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005665	cellular_component	RNA polymerase II, core complex
F	0005666	cellular_component	RNA polymerase III complex
F	0005736	cellular_component	RNA polymerase I complex
F	0006351	biological_process	DNA-templated transcription
F	0006360	biological_process	transcription by RNA polymerase I
F	0006366	biological_process	transcription by RNA polymerase II
F	0042797	biological_process	tRNA transcription by RNA polymerase III
G	0000428	cellular_component	DNA-directed RNA polymerase complex
G	0003676	molecular_function	nucleic acid binding
G	0005634	cellular_component	nucleus
G	0006351	biological_process	DNA-templated transcription
G	0006352	biological_process	DNA-templated transcription initiation
H	0000428	cellular_component	DNA-directed RNA polymerase complex
H	0003899	molecular_function	DNA-directed RNA polymerase activity
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005665	cellular_component	RNA polymerase II, core complex
H	0005666	cellular_component	RNA polymerase III complex
H	0005736	cellular_component	RNA polymerase I complex
H	0006351	biological_process	DNA-templated transcription
I	0000428	cellular_component	DNA-directed RNA polymerase complex
I	0001193	biological_process	maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II
I	0003676	molecular_function	nucleic acid binding
I	0003899	molecular_function	DNA-directed RNA polymerase activity
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005665	cellular_component	RNA polymerase II, core complex
I	0005730	cellular_component	nucleolus
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006366	biological_process	transcription by RNA polymerase II
I	0006367	biological_process	transcription initiation at RNA polymerase II promoter
I	0008270	molecular_function	zinc ion binding
I	0046872	molecular_function	metal ion binding
J	0000428	cellular_component	DNA-directed RNA polymerase complex
J	0003677	molecular_function	DNA binding
J	0003899	molecular_function	DNA-directed RNA polymerase activity
J	0005634	cellular_component	nucleus
J	0005665	cellular_component	RNA polymerase II, core complex
J	0005666	cellular_component	RNA polymerase III complex
J	0005736	cellular_component	RNA polymerase I complex
J	0006351	biological_process	DNA-templated transcription
J	0006360	biological_process	transcription by RNA polymerase I
J	0006366	biological_process	transcription by RNA polymerase II
J	0008270	molecular_function	zinc ion binding
J	0042797	biological_process	tRNA transcription by RNA polymerase III
J	0046872	molecular_function	metal ion binding
K	0000428	cellular_component	DNA-directed RNA polymerase complex
K	0003677	molecular_function	DNA binding
K	0003899	molecular_function	DNA-directed RNA polymerase activity
K	0005634	cellular_component	nucleus
K	0005665	cellular_component	RNA polymerase II, core complex
K	0006351	biological_process	DNA-templated transcription
K	0006366	biological_process	transcription by RNA polymerase II
K	0046983	molecular_function	protein dimerization activity
L	0000428	cellular_component	DNA-directed RNA polymerase complex
L	0003677	molecular_function	DNA binding
L	0003899	molecular_function	DNA-directed RNA polymerase activity
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005665	cellular_component	RNA polymerase II, core complex
L	0005666	cellular_component	RNA polymerase III complex
L	0005730	cellular_component	nucleolus
L	0005736	cellular_component	RNA polymerase I complex
L	0006351	biological_process	DNA-templated transcription
L	0006366	biological_process	transcription by RNA polymerase II
L	0008270	molecular_function	zinc ion binding
L	0046872	molecular_function	metal ion binding
U	0003682	molecular_function	chromatin binding
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005829	cellular_component	cytosol
U	0016604	cellular_component	nuclear body
U	0032021	cellular_component	NELF complex
U	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
U	0045944	biological_process	positive regulation of transcription by RNA polymerase II
U	0060090	molecular_function	molecular adaptor activity
V	0003723	molecular_function	RNA binding
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0008283	biological_process	cell population proliferation
V	0032021	cellular_component	NELF complex
V	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
V	0045892	biological_process	negative regulation of DNA-templated transcription
V	0048863	biological_process	stem cell differentiation
V	2000737	biological_process	negative regulation of stem cell differentiation
W	0003723	molecular_function	RNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0016020	cellular_component	membrane
W	0032021	cellular_component	NELF complex
W	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
W	0045892	biological_process	negative regulation of DNA-templated transcription
X	0000122	biological_process	negative regulation of transcription by RNA polymerase II
X	0000785	cellular_component	chromatin
X	0003676	molecular_function	nucleic acid binding
X	0003682	molecular_function	chromatin binding
X	0003723	molecular_function	RNA binding
X	0003729	molecular_function	mRNA binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005694	cellular_component	chromosome
X	0005886	cellular_component	plasma membrane
X	0006355	biological_process	regulation of DNA-templated transcription
X	0006366	biological_process	transcription by RNA polymerase II
X	0016604	cellular_component	nuclear body
X	0032021	cellular_component	NELF complex
X	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
X	0045944	biological_process	positive regulation of transcription by RNA polymerase II
X	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
X	0160239	biological_process	transcription pausing by RNA polymerase II
Y	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Y	0000993	molecular_function	RNA polymerase II complex binding
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0006355	biological_process	regulation of DNA-templated transcription
Y	0006368	biological_process	transcription elongation by RNA polymerase II
Y	0008270	molecular_function	zinc ion binding
Y	0032044	cellular_component	DSIF complex
Y	0032785	biological_process	negative regulation of DNA-templated transcription, elongation
Y	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
Y	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
Y	0034244	biological_process	negative regulation of transcription elongation by RNA polymerase II
Y	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Y	0046872	molecular_function	metal ion binding
Y	0046982	molecular_function	protein heterodimerization activity
Y	0140673	biological_process	transcription elongation-coupled chromatin remodeling
Z	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Z	0003682	molecular_function	chromatin binding
Z	0003723	molecular_function	RNA binding
Z	0003729	molecular_function	mRNA binding
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0006354	biological_process	DNA-templated transcription elongation
Z	0006357	biological_process	regulation of transcription by RNA polymerase II
Z	0006368	biological_process	transcription elongation by RNA polymerase II
Z	0016239	biological_process	positive regulation of macroautophagy
Z	0019899	molecular_function	enzyme binding
Z	0032044	cellular_component	DSIF complex
Z	0032784	biological_process	regulation of DNA-templated transcription elongation
Z	0032785	biological_process	negative regulation of DNA-templated transcription, elongation
Z	0032786	biological_process	positive regulation of DNA-templated transcription, elongation
Z	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
Z	0034243	biological_process	regulation of transcription elongation by RNA polymerase II
Z	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Z	0046982	molecular_function	protein heterodimerization activity
a	0000775	cellular_component	chromosome, centromeric region
a	0000781	cellular_component	chromosome, telomeric region
a	0000785	cellular_component	chromatin
a	0000786	cellular_component	nucleosome
a	0000939	cellular_component	inner kinetochore
a	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
a	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
a	0001556	biological_process	oocyte maturation
a	0001649	biological_process	osteoblast differentiation
a	0001740	cellular_component	Barr body
a	0003677	molecular_function	DNA binding
a	0005515	molecular_function	protein binding
a	0005576	cellular_component	extracellular region
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005694	cellular_component	chromosome
a	0006334	biological_process	nucleosome assembly
a	0006997	biological_process	nucleus organization
a	0007283	biological_process	spermatogenesis
a	0007286	biological_process	spermatid development
a	0007338	biological_process	single fertilization
a	0007566	biological_process	embryo implantation
a	0008283	biological_process	cell population proliferation
a	0008584	biological_process	male gonad development
a	0030307	biological_process	positive regulation of cell growth
a	0030527	molecular_function	structural constituent of chromatin
a	0031492	molecular_function	nucleosomal DNA binding
a	0031508	biological_process	pericentric heterochromatin formation
a	0031509	biological_process	subtelomeric heterochromatin formation
a	0032200	biological_process	telomere organization
a	0032991	cellular_component	protein-containing complex
a	0035264	biological_process	multicellular organism growth
a	0042692	biological_process	muscle cell differentiation
a	0046982	molecular_function	protein heterodimerization activity
a	0048477	biological_process	oogenesis
a	0070062	cellular_component	extracellular exosome
a	0090230	biological_process	regulation of centromere complex assembly
a	1902340	biological_process	negative regulation of chromosome condensation
b	0000781	cellular_component	chromosome, telomeric region
b	0000786	cellular_component	nucleosome
b	0003677	molecular_function	DNA binding
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005576	cellular_component	extracellular region
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005694	cellular_component	chromosome
b	0006325	biological_process	chromatin organization
b	0006334	biological_process	nucleosome assembly
b	0016020	cellular_component	membrane
b	0030527	molecular_function	structural constituent of chromatin
b	0032200	biological_process	telomere organization
b	0032991	cellular_component	protein-containing complex
b	0043505	cellular_component	CENP-A containing nucleosome
b	0045653	biological_process	negative regulation of megakaryocyte differentiation
b	0046982	molecular_function	protein heterodimerization activity
b	0061644	biological_process	protein localization to CENP-A containing chromatin
b	0070062	cellular_component	extracellular exosome
c	0000786	cellular_component	nucleosome
c	0003677	molecular_function	DNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005694	cellular_component	chromosome
c	0006325	biological_process	chromatin organization
c	0008285	biological_process	negative regulation of cell population proliferation
c	0030527	molecular_function	structural constituent of chromatin
c	0031507	biological_process	heterochromatin formation
c	0043505	cellular_component	CENP-A containing nucleosome
c	0046982	molecular_function	protein heterodimerization activity
c	0061644	biological_process	protein localization to CENP-A containing chromatin
c	0070062	cellular_component	extracellular exosome
d	0000786	cellular_component	nucleosome
d	0001530	molecular_function	lipopolysaccharide binding
d	0002227	biological_process	innate immune response in mucosa
d	0003677	molecular_function	DNA binding
d	0005515	molecular_function	protein binding
d	0005615	cellular_component	extracellular space
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005694	cellular_component	chromosome
d	0005829	cellular_component	cytosol
d	0005886	cellular_component	plasma membrane
d	0006325	biological_process	chromatin organization
d	0006334	biological_process	nucleosome assembly
d	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
d	0019731	biological_process	antibacterial humoral response
d	0030527	molecular_function	structural constituent of chromatin
d	0031640	biological_process	killing of cells of another organism
d	0042742	biological_process	defense response to bacterium
d	0043505	cellular_component	CENP-A containing nucleosome
d	0046982	molecular_function	protein heterodimerization activity
d	0050829	biological_process	defense response to Gram-negative bacterium
d	0050830	biological_process	defense response to Gram-positive bacterium
d	0061644	biological_process	protein localization to CENP-A containing chromatin
d	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
e	0000775	cellular_component	chromosome, centromeric region
e	0000781	cellular_component	chromosome, telomeric region
e	0000785	cellular_component	chromatin
e	0000786	cellular_component	nucleosome
e	0000939	cellular_component	inner kinetochore
e	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
e	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
e	0001556	biological_process	oocyte maturation
e	0001649	biological_process	osteoblast differentiation
e	0001740	cellular_component	Barr body
e	0003677	molecular_function	DNA binding
e	0005515	molecular_function	protein binding
e	0005576	cellular_component	extracellular region
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005694	cellular_component	chromosome
e	0006334	biological_process	nucleosome assembly
e	0006997	biological_process	nucleus organization
e	0007283	biological_process	spermatogenesis
e	0007286	biological_process	spermatid development
e	0007338	biological_process	single fertilization
e	0007566	biological_process	embryo implantation
e	0008283	biological_process	cell population proliferation
e	0008584	biological_process	male gonad development
e	0030307	biological_process	positive regulation of cell growth
e	0030527	molecular_function	structural constituent of chromatin
e	0031492	molecular_function	nucleosomal DNA binding
e	0031508	biological_process	pericentric heterochromatin formation
e	0031509	biological_process	subtelomeric heterochromatin formation
e	0032200	biological_process	telomere organization
e	0032991	cellular_component	protein-containing complex
e	0035264	biological_process	multicellular organism growth
e	0042692	biological_process	muscle cell differentiation
e	0046982	molecular_function	protein heterodimerization activity
e	0048477	biological_process	oogenesis
e	0070062	cellular_component	extracellular exosome
e	0090230	biological_process	regulation of centromere complex assembly
e	1902340	biological_process	negative regulation of chromosome condensation
f	0000781	cellular_component	chromosome, telomeric region
f	0000786	cellular_component	nucleosome
f	0003677	molecular_function	DNA binding
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005576	cellular_component	extracellular region
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005694	cellular_component	chromosome
f	0006325	biological_process	chromatin organization
f	0006334	biological_process	nucleosome assembly
f	0016020	cellular_component	membrane
f	0030527	molecular_function	structural constituent of chromatin
f	0032200	biological_process	telomere organization
f	0032991	cellular_component	protein-containing complex
f	0043505	cellular_component	CENP-A containing nucleosome
f	0045653	biological_process	negative regulation of megakaryocyte differentiation
f	0046982	molecular_function	protein heterodimerization activity
f	0061644	biological_process	protein localization to CENP-A containing chromatin
f	0070062	cellular_component	extracellular exosome
g	0000786	cellular_component	nucleosome
g	0003677	molecular_function	DNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005694	cellular_component	chromosome
g	0006325	biological_process	chromatin organization
g	0008285	biological_process	negative regulation of cell population proliferation
g	0030527	molecular_function	structural constituent of chromatin
g	0031507	biological_process	heterochromatin formation
g	0043505	cellular_component	CENP-A containing nucleosome
g	0046982	molecular_function	protein heterodimerization activity
g	0061644	biological_process	protein localization to CENP-A containing chromatin
g	0070062	cellular_component	extracellular exosome
h	0000786	cellular_component	nucleosome
h	0001530	molecular_function	lipopolysaccharide binding
h	0002227	biological_process	innate immune response in mucosa
h	0003677	molecular_function	DNA binding
h	0005515	molecular_function	protein binding
h	0005615	cellular_component	extracellular space
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005694	cellular_component	chromosome
h	0005829	cellular_component	cytosol
h	0005886	cellular_component	plasma membrane
h	0006325	biological_process	chromatin organization
h	0006334	biological_process	nucleosome assembly
h	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
h	0019731	biological_process	antibacterial humoral response
h	0030527	molecular_function	structural constituent of chromatin
h	0031640	biological_process	killing of cells of another organism
h	0042742	biological_process	defense response to bacterium
h	0043505	cellular_component	CENP-A containing nucleosome
h	0046982	molecular_function	protein heterodimerization activity
h	0050829	biological_process	defense response to Gram-negative bacterium
h	0050830	biological_process	defense response to Gram-positive bacterium
h	0061644	biological_process	protein localization to CENP-A containing chromatin
h	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DNDPSDYVEqdDI

Chain	Residue	Details
C	ASP136-ILE148

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site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
c	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
b	GLY14-HIS18

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPA

Chain	Residue	Details
A	TYR1593-ALA1599
A	TYR1671-SER1677
A	TYR1678-SER1684
A	TYR1685-SER1691
A	TYR1692-SER1698
A	TYR1699-SER1705
A	TYR1706-SER1712
A	TYR1713-SER1719
A	TYR1720-SER1726
A	TYR1727-SER1733
A	TYR1734-SER1740
A	TYR1615-SER1621
A	TYR1741-ASN1747
A	TYR1748-ASN1754
A	TYR1755-SER1761
A	TYR1762-SER1768
A	TYR1769-ASN1775
A	TYR1776-ASN1782
A	TYR1783-SER1789
A	TYR1790-SER1796
A	TYR1797-SER1803
A	TYR1818-SER1824
A	TYR1622-SER1628
A	TYR1825-SER1831
A	TYR1832-LYS1838
A	TYR1839-SER1845
A	TYR1853-LYS1859
A	TYR1860-LYS1866
A	TYR1867-LYS1873
A	TYR1874-THR1880
A	TYR1888-THR1894
A	TYR1902-LYS1908
A	TYR1909-THR1915
A	TYR1629-ASN1635
A	TYR1916-LYS1922
A	TYR1923-THR1929
A	TYR1930-LYS1936
A	TYR1947-THR1953
A	TYR1636-SER1642
A	TYR1643-SER1649
A	TYR1650-SER1656
A	TYR1657-SER1663
A	TYR1664-SER1670

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YVCTAPH

Chain	Residue	Details
I	TYR112-HIS118

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site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
a	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
d	ARG89-GLY111

---

site_id	PS00446
Number of Residues	41
Details	RNA_POL_D_30KD RNA polymerases D / 30 to 40 Kd subunits signature. NSIRRvfiaevpiiAidwVqidaNsSvlhDEfIAhRLGLIP

Chain	Residue	Details
C	ASN32-PRO72

---

site_id	PS00466
Number of Residues	38
Details	ZF_TFIIS_1 Zinc finger TFIIS-type signature. CqkCghkeavffqSHSARaEDAmrlyyvCtaph.CghrW

Chain	Residue	Details
I	CYS86-TRP123

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
a	PRO66-ILE74

---

site_id	PS01030
Number of Residues	27
Details	RNA_POL_M_15KD RNA polymerases M / 15 Kd subunits signature. FCQECNNMLypkedkenrillyaCrnC

Chain	Residue	Details
I	PHE16-CYS42

---

site_id	PS01110
Number of Residues	14
Details	RNA_POL_H_23KD RNA polymerases H / 23 Kd subunits signature. HELVPEHvvMtkEE

Chain	Residue	Details
E	HIS142-GLU155

---

site_id	PS01111
Number of Residues	15
Details	RNA_POL_K_14KD RNA polymerases K / 14 to 18 Kd subunits signature. TkYErARvLGtRAlQ

Chain	Residue	Details
F	THR58-GLN72

---

site_id	PS01112
Number of Residues	10
Details	RNA_POL_N_8KD RNA polymerases N / 8 Kd subunits signature. IIPVrCFTCG

Chain	Residue	Details
J	ILE2-GLY11

---

site_id	PS01154
Number of Residues	32
Details	RNA_POL_L_13KD RNA polymerases L / 13 to 16 Kd subunits signature. InkEdHTLgNiIksqLlkdpqVlfagYkvpHP

Chain	Residue	Details
K	ILE35-PRO66

---

site_id	PS01166
Number of Residues	13
Details	RNA_POL_BETA RNA polymerases beta chain signature. GdKFASrHGQKGT

Chain	Residue	Details
B	GLY932-THR944

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
X	SER51
X	SER139
X	SER165
X	SER249

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
X	SER113
U	SER233
Y	CYS33
Y	CYS36

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
X	SER115
h	LYS8
h	LYS12
h	LYS13
h	LYS17
h	LYS20
h	LYS40
h	LYS82
d	LYS8
d	LYS12
d	LYS13
d	LYS17
d	LYS20
d	LYS40
d	LYS82
h	LYS2

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: PolyADP-ribosyl glutamic acid => ECO:0000269|PubMed:27256882

Chain	Residue	Details
X	GLU122
X	GLU151
X	GLU172
X	GLU374

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
X	SER131
h	LYS9
b	LYS44
f	LYS8
f	LYS16
f	LYS44

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
X	SER179
h	SER11
b	LYS77
b	LYS91
f	LYS12
f	LYS31
f	LYS77
f	LYS91

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CDK9 => ECO:0000305|PubMed:14701750, ECO:0007744|PubMed:21406692

Chain	Residue	Details
X	SER181
X	SER185
g	LYS74
g	LYS75

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CDK9 => ECO:0000305|PubMed:14701750

Chain	Residue	Details
X	SER187
X	SER191
d	LYS117
h	LYS31
h	LYS113
h	LYS117

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
X	SER251
h	GLU32
c	LYS125
g	LYS118
g	LYS119
g	LYS125

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
X	THR272
X	THR274

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231

Chain	Residue	Details
X	SER281
d	LYS105
h	LYS43
h	LYS105

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
X	SER353
h	LYS54
g	LYS119

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
X	LYS78
h	ARG76
e	LYS18
e	LYS64

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
d	ARG83
X	LYS82
h	ARG83
h	ARG89

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q00729

Chain	Residue	Details
d	THR112
h	THR112
f	LYS91

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250|UniProtKB:P62807

Chain	Residue	Details
d	SER109
h	SER109
b	LYS79
f	LYS20
f	LYS59
f	LYS79

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P58876

Chain	Residue	Details
d	LYS2
h	LYS2

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:16713563

Chain	Residue	Details
a	SER31
d	LYS117
h	LYS117

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:Q5QNW6

Chain	Residue	Details
d	LYS17
h	LYS17

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:21726816

Chain	Residue	Details
d	LYS31
h	LYS31

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:20850016

Chain	Residue	Details
a	SER57
e	SER57

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:29211711

Chain	Residue	Details
a	LYS79
e	LYS79

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:20850016

Chain	Residue	Details
a	THR80
e	THR80

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
a	SER86
e	SER86

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
a	THR107
e	THR107

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297

Chain	Residue	Details
a	LYS115
e	LYS115

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435, ECO:0000269|PubMed:27436229

Chain	Residue	Details
a	LYS122
e	LYS122

---

site_id	SWS_FT_FI28
Number of Residues	2
Details	LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806

Chain	Residue	Details
a	LYS18
e	LYS18

---