9IUL
The structure of Candida albicans Cdr1 in fluconazole-bound state
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009986 | cellular_component | cell surface |
| A | 0015244 | molecular_function | fluconazole transmembrane transporter activity |
| A | 0015247 | molecular_function | aminophospholipid flippase activity |
| A | 0015903 | biological_process | fluconazole transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0017111 | molecular_function | ribonucleoside triphosphate phosphatase activity |
| A | 0042626 | molecular_function | ATPase-coupled transmembrane transporter activity |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0045117 | biological_process | azole transmembrane transport |
| A | 0045332 | biological_process | phospholipid translocation |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0046898 | biological_process | response to cycloheximide |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0090554 | molecular_function | phosphatidylcholine floppase activity |
| A | 0090556 | molecular_function | phosphatidylserine floppase activity |
| A | 0140331 | biological_process | aminophospholipid translocation |
| A | 0140341 | molecular_function | phosphatidylethanolamine floppase activity |
| A | 0140359 | molecular_function | ABC-type transporter activity |
| A | 1901474 | molecular_function | azole transmembrane transporter activity |
| A | 1903561 | cellular_component | extracellular vesicle |
| A | 1903875 | molecular_function | corticosterone binding |
| A | 1903924 | molecular_function | estradiol binding |
| A | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. VSGGERKRVSIAEAS |
| Chain | Residue | Details |
| A | VAL303-SER317 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1019 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-SER513 | |
| A | GLU570-GLU597 | |
| A | ARG644-SER654 | |
| A | ASN786-GLY1195 | |
| A | VAL1251-GLU1280 | |
| A | CYS1336-THR1355 | |
| A | ALA1488-LYS1501 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE514-TYR534 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 217 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | ASN535-ALA548 | |
| A | ARG619-PRO622 | |
| A | PRO676-ASN764 | |
| A | LYS1217-MET1229 | |
| A | TYR1302-ARG1314 | |
| A | MET1377-ASN1466 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA549-PHE569 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU598-PHE618 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY623-PHE643 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY655-ILE675 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU765-PHE785 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR1196-PHE1216 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE1230-PHE1250 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE1281-LEU1301 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY1315-LEU1335 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1356-PHE1376 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE1467-LEU1487 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 |
| Chain | Residue | Details |
| A | GLY895 |
