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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9IQY

Cryo-EM structure of human TRPV4 intracellular domain in complex with GTPase RhoA

Functional Information from GO Data
ChainGOidnamespacecontents
B0005216molecular_functionmonoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0055085biological_processtransmembrane transport
C0005216molecular_functionmonoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0055085biological_processtransmembrane transport
J0000166molecular_functionnucleotide binding
J0000281biological_processmitotic cytokinesis
J0002363biological_processalpha-beta T cell lineage commitment
J0003189biological_processaortic valve formation
J0003924molecular_functionGTPase activity
J0003925molecular_functionG protein activity
J0005515molecular_functionprotein binding
J0005525molecular_functionGTP binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005768cellular_componentendosome
J0005789cellular_componentendoplasmic reticulum membrane
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005886cellular_componentplasma membrane
J0005925cellular_componentfocal adhesion
J0005938cellular_componentcell cortex
J0007264biological_processsmall GTPase-mediated signal transduction
J0007266biological_processRho protein signal transduction
J0009898cellular_componentcytoplasmic side of plasma membrane
J0010812biological_processnegative regulation of cell-substrate adhesion
J0016477biological_processcell migration
J0016787molecular_functionhydrolase activity
J0017022molecular_functionmyosin binding
J0019901molecular_functionprotein kinase binding
J0021762biological_processsubstantia nigra development
J0030027cellular_componentlamellipodium
J0030036biological_processactin cytoskeleton organization
J0030054cellular_componentcell junction
J0030334biological_processregulation of cell migration
J0030335biological_processpositive regulation of cell migration
J0030425cellular_componentdendrite
J0030496cellular_componentmidbody
J0030667cellular_componentsecretory granule membrane
J0031122biological_processcytoplasmic microtubule organization
J0031982cellular_componentvesicle
J0032154cellular_componentcleavage furrow
J0032467biological_processpositive regulation of cytokinesis
J0032587cellular_componentruffle membrane
J0032956biological_processregulation of actin cytoskeleton organization
J0033688biological_processregulation of osteoblast proliferation
J0034329biological_processcell junction assembly
J0034446biological_processsubstrate adhesion-dependent cell spreading
J0035385biological_processRoundabout signaling pathway
J0036089biological_processcleavage furrow formation
J0038027biological_processapolipoprotein A-I-mediated signaling pathway
J0042476biological_processodontogenesis
J0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
J0043149biological_processstress fiber assembly
J0043197cellular_componentdendritic spine
J0043296cellular_componentapical junction complex
J0043297biological_processapical junction assembly
J0043366biological_processbeta selection
J0043542biological_processendothelial cell migration
J0043931biological_processossification involved in bone maturation
J0044319biological_processwound healing, spreading of cells
J0045198biological_processestablishment of epithelial cell apical/basal polarity
J0045666biological_processpositive regulation of neuron differentiation
J0045792biological_processnegative regulation of cell size
J0046638biological_processpositive regulation of alpha-beta T cell differentiation
J0050919biological_processnegative chemotaxis
J0051301biological_processcell division
J0051496biological_processpositive regulation of stress fiber assembly
J0051893biological_processregulation of focal adhesion assembly
J0060071biological_processWnt signaling pathway, planar cell polarity pathway
J0060193biological_processpositive regulation of lipase activity
J0061430biological_processbone trabecula morphogenesis
J0070062cellular_componentextracellular exosome
J0070507biological_processregulation of microtubule cytoskeleton organization
J0071222biological_processcellular response to lipopolysaccharide
J0071345biological_processcellular response to cytokine stimulus
J0071526biological_processsemaphorin-plexin signaling pathway
J0071902biological_processpositive regulation of protein serine/threonine kinase activity
J0071944cellular_componentcell periphery
J0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
J0090307biological_processmitotic spindle assembly
J0090324biological_processnegative regulation of oxidative phosphorylation
J0097498biological_processendothelial tube lumen extension
J0098794cellular_componentpostsynapse
J0098978cellular_componentglutamatergic synapse
J0099159biological_processregulation of modification of postsynaptic structure
J0101003cellular_componentficolin-1-rich granule membrane
J1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
J1902766biological_processskeletal muscle satellite cell migration
J1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
J1903673biological_processmitotic cleavage furrow formation
J1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
J1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
J1990869biological_processcellular response to chemokine
J2000406biological_processpositive regulation of T cell migration
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues29
DetailsRepeat: {"description":"ANK 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues29
DetailsRepeat: {"description":"ANK 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues29
DetailsRepeat: {"description":"ANK 3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"22702953","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4DX2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"A0A1D5PXA5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9EPK8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues17
DetailsRegion: {"description":"Switch II region; involved in RAP1GDS1 isoform 2 binding","evidences":[{"source":"PubMed","id":"30190425","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZHX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"10748207","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12777804","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues13
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"(Microbial infection) ADP-ribosylasparagine; by botulinum toxin","evidences":[{"source":"PubMed","id":"1328215","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl serotonin","evidences":[{"source":"UniProtKB","id":"Q9QUI0","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsGlycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23871831","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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