9INH
Cryo-EM structure of human XPR1 in complex with InsP6 in outward-facing state (SPX visible)-in the presence of KIDINS220-1-432 and 10 mM KH2PO4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000822 | molecular_function | inositol hexakisphosphate binding |
| A | 0001618 | molecular_function | virus receptor activity |
| A | 0005315 | molecular_function | phosphate transmembrane transporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006817 | biological_process | phosphate ion transport |
| A | 0009615 | biological_process | response to virus |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016036 | biological_process | cellular response to phosphate starvation |
| A | 0030643 | biological_process | intracellular phosphate ion homeostasis |
| A | 0035435 | biological_process | phosphate ion transmembrane transport |
| A | 0046718 | biological_process | symbiont entry into host cell |
| D | 0000822 | molecular_function | inositol hexakisphosphate binding |
| D | 0001618 | molecular_function | virus receptor activity |
| D | 0005315 | molecular_function | phosphate transmembrane transporter activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006817 | biological_process | phosphate ion transport |
| D | 0009615 | biological_process | response to virus |
| D | 0015562 | molecular_function | efflux transmembrane transporter activity |
| D | 0016020 | cellular_component | membrane |
| D | 0016036 | biological_process | cellular response to phosphate starvation |
| D | 0030643 | biological_process | intracellular phosphate ion homeostasis |
| D | 0035435 | biological_process | phosphate ion transmembrane transport |
| D | 0046718 | biological_process | symbiont entry into host cell |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 980 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-ARG236 | |
| D | ASP529-THR696 | |
| A | GLY286-GLU318 | |
| A | LYS369-LYS376 | |
| A | ASP424-ALA473 | |
| A | ASP529-THR696 | |
| D | MET1-ARG236 | |
| D | GLY286-GLU318 | |
| D | LYS369-LYS376 | |
| D | ASP424-ALA473 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 328 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL237-PHE257 | |
| D | ILE265-LEU285 | |
| D | ILE319-ILE339 | |
| D | VAL346-TYR368 | |
| D | LEU377-ALA397 | |
| D | LEU403-TRP423 | |
| D | PHE474-TYR496 | |
| D | MET508-TRP528 | |
| A | ILE265-LEU285 | |
| A | ILE319-ILE339 | |
| A | VAL346-TYR368 | |
| A | LEU377-ALA397 | |
| A | LEU403-TRP423 | |
| A | PHE474-TYR496 | |
| A | MET508-TRP528 | |
| D | VAL237-PHE257 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 50 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS258-SER264 | |
| A | SER340-TYR345 | |
| A | ASP398-SER402 | |
| A | SER497-THR507 | |
| D | LYS258-SER264 | |
| D | SER340-TYR345 | |
| D | ASP398-SER402 | |
| D | SER497-THR507 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Important for inositol polyphosphate binding => ECO:0000305|PubMed:27080106 |
| Chain | Residue | Details |
| A | TYR22 | |
| A | LYS26 | |
| D | TYR22 | |
| D | LYS26 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER668 | |
| D | SER668 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | THR690 | |
| D | THR690 |
