9I8V

Cryo-EM structure of the Danio rerio tRNA ligase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000166	molecular_function	nucleotide binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
C	0006396	biological_process	RNA processing
C	0008033	biological_process	tRNA processing
C	0008452	molecular_function	RNA ligase activity
C	0016874	molecular_function	ligase activity
C	0016886	molecular_function	ligase activity, forming phosphoric ester bonds
C	0046872	molecular_function	metal ion binding
C	0072669	cellular_component	tRNA-splicing ligase complex
C	0170057	molecular_function	RNA ligase (GTP) activity
E	0000993	molecular_function	RNA polymerase II complex binding
E	0003723	molecular_function	RNA binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006388	biological_process	tRNA splicing, via endonucleolytic cleavage and ligation
E	0006469	biological_process	negative regulation of protein kinase activity
E	0008033	biological_process	tRNA processing
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0072669	cellular_component	tRNA-splicing ligase complex
E	0072686	cellular_component	mitotic spindle
F	0048598	biological_process	embryonic morphogenesis
F	0072669	cellular_component	tRNA-splicing ligase complex

Functional Information from PROSITE/UniProt

site_id	PS01288
Number of Residues	30
Details	UPF0027 Uncharacterized protein family UPF0027 signature. QIgNvAaLPgIvhrsigLPDvHsGyGfaIG

Chain	Residue	Details
C	GLN68-GLY97

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"GMP-histidine intermediate","evidences":[{"source":"UniProtKB","id":"Q9Y3I0","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_03144","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Y3I0","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_03144","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Y3I0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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