Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9I3V

Cryo-EM structure of the human LRP2 ectodomain

This is a non-PDB format compatible entry.

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CyNmrgsFrCsC

Chain	Residue	Details
A	CYS1404-CYS1415
A	CYS3126-CYS3137
A	CYS3167-CYS3178
A	CYS4021-CYS4032

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CkCpsGytGKyC

Chain	Residue	Details
A	CYS4399-CYS4410

site_id	PS00307
Number of Residues	7
Details	LECTIN_LEGUME_BETA Legume lectins beta-chain signature. VAVDFDS

Chain	Residue	Details
A	VAL1469-SER1475

site_id	PS01186
Number of Residues	15
Details	EGF_2 EGF-like domain signature 2. ChCeeGYilergqy.C

Chain	Residue	Details
A	CYS371-CYS385
A	CYS689-CYS704
A	CYS1373-CYS1388
A	CYS1413-CYS1428
A	CYS1725-CYS1740
A	CYS2043-CYS2058
A	CYS3135-CYS3150
A	CYS3176-CYS3191
A	CYS4399-CYS4410

site_id	PS01187
Number of Residues	24
Details	EGF_CA Calcium-binding EGF-like domain signature. DiDECdilgs.........Csqh....CyNmrgsFrC

Chain	Residue	Details
A	ASP1390-CYS1413
A	ASP3152-CYS3176
A	ASP4007-CYS4030

site_id	PS01209
Number of Residues	23
Details	LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIpadwr.CDgtkDCsdd.ADEig...C

Chain	Residue	Details
A	CYS40-CYS62
A	CYS1200-CYS1222
A	CYS1243-CYS1266
A	CYS1283-CYS1305
A	CYS1325-CYS1348
A	CYS2712-CYS2736
A	CYS2753-CYS2775
A	CYS2835-CYS2859
A	CYS2876-CYS2899
A	CYS2918-CYS2943
A	CYS3005-CYS3027
A	CYS80-CYS103
A	CYS3044-CYS3068
A	CYS3087-CYS3109
A	CYS3525-CYS3548
A	CYS3606-CYS3630
A	CYS3647-CYS3671
A	CYS3692-CYS3714
A	CYS3732-CYS3754
A	CYS3771-CYS3793
A	CYS3810-CYS3832
A	CYS3854-CYS3878
A	CYS120-CYS142
A	CYS3896-CYS3920
A	CYS3940-CYS3962
A	CYS195-CYS217
A	CYS234-CYS256
A	CYS1038-CYS1060
A	CYS1079-CYS1101
A	CYS1121-CYS1143
A	CYS1161-CYS1183

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	92
Details	Repeat: {"description":"LDL-receptor class B 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	88
Details	Repeat: {"description":"LDL-receptor class B 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	74
Details	Domain: {"description":"LDL-receptor class A 12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 13","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 14","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	78
Details	Domain: {"description":"EGF-like 1; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 10","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 11","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	88
Details	Repeat: {"description":"LDL-receptor class B 12","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	80
Details	Repeat: {"description":"LDL-receptor class B 13","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	82
Details	Domain: {"description":"EGF-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 14","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	98
Details	Repeat: {"description":"LDL-receptor class B 15","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	94
Details	Repeat: {"description":"LDL-receptor class B 16","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 17","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	80
Details	Repeat: {"description":"LDL-receptor class B 18","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	98
Details	Repeat: {"description":"LDL-receptor class B 19","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	88
Details	Repeat: {"description":"LDL-receptor class B 20","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 21","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 22","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	92
Details	Repeat: {"description":"LDL-receptor class B 23","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	80
Details	Repeat: {"description":"LDL-receptor class B 24","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 25","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 26","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 27","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 16","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 17","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 24","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 25","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	82
Details	Domain: {"description":"EGF-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	80
Details	Domain: {"description":"EGF-like 4; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 28","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 29","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 30","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 31","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	80
Details	Repeat: {"description":"LDL-receptor class B 32","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 26","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 27","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 28","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 29","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	76
Details	Domain: {"description":"LDL-receptor class A 30","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	74
Details	Domain: {"description":"LDL-receptor class A 31","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 32","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	72
Details	Domain: {"description":"LDL-receptor class A 33","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	38
Details	Domain: {"description":"LDL-receptor class A 34","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	84
Details	Repeat: {"description":"LDL-receptor class B 33","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	86
Details	Repeat: {"description":"LDL-receptor class B 34","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI60
Number of Residues	82
Details	Repeat: {"description":"LDL-receptor class B 35","evidences":[{"source":"PROSITE-ProRule","id":"PRU00461","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI61
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23275343","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2M0P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI62
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P98158","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI63
Number of Residues	56
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)