9HZL

High resolution cryo-EM structure of human complex III in mitochondria

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0021539	biological_process	subthalamus development
A	0021548	biological_process	pons development
A	0021680	biological_process	cerebellar Purkinje cell layer development
A	0021766	biological_process	hippocampus development
A	0021794	biological_process	thalamus development
A	0021854	biological_process	hypothalamus development
A	0021860	biological_process	pyramidal neuron development
A	0030901	biological_process	midbrain development
A	0045275	cellular_component	respiratory chain complex III
A	0045333	biological_process	cellular respiration
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005759	cellular_component	mitochondrial matrix
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0008121	molecular_function	quinol-cytochrome-c reductase activity
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0022904	biological_process	respiratory electron transport chain
B	0031966	cellular_component	mitochondrial membrane
B	0034551	biological_process	mitochondrial respiratory chain complex III assembly
B	0045275	cellular_component	respiratory chain complex III
B	0051537	molecular_function	2 iron, 2 sulfur cluster binding
B	1902600	biological_process	proton transmembrane transport
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005759	cellular_component	mitochondrial matrix
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	quinol-cytochrome-c reductase activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0022904	biological_process	respiratory electron transport chain
C	0031966	cellular_component	mitochondrial membrane
C	0034551	biological_process	mitochondrial respiratory chain complex III assembly
C	0045275	cellular_component	respiratory chain complex III
C	0051537	molecular_function	2 iron, 2 sulfur cluster binding
C	1902600	biological_process	proton transmembrane transport
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0008121	molecular_function	quinol-cytochrome-c reductase activity
D	0045275	cellular_component	respiratory chain complex III
D	0045333	biological_process	cellular respiration
D	1902600	biological_process	proton transmembrane transport
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006119	biological_process	oxidative phosphorylation
E	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
E	0008121	molecular_function	quinol-cytochrome-c reductase activity
E	0009060	biological_process	aerobic respiration
E	0045275	cellular_component	respiratory chain complex III
E	0045333	biological_process	cellular respiration
E	0098803	cellular_component	respiratory chain complex
E	1902600	biological_process	proton transmembrane transport
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006119	biological_process	oxidative phosphorylation
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0009060	biological_process	aerobic respiration
F	0045275	cellular_component	respiratory chain complex III
F	0045333	biological_process	cellular respiration
F	0098803	cellular_component	respiratory chain complex
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006091	biological_process	generation of precursor metabolites and energy
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0009055	molecular_function	electron transfer activity
G	0045275	cellular_component	respiratory chain complex III
G	0045333	biological_process	cellular respiration
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0008121	molecular_function	quinol-cytochrome-c reductase activity
H	0009055	molecular_function	electron transfer activity
H	0016020	cellular_component	membrane
H	0020037	molecular_function	heme binding
H	0033762	biological_process	response to glucagon
H	0045275	cellular_component	respiratory chain complex III
H	0045333	biological_process	cellular respiration
H	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0008121	molecular_function	quinol-cytochrome-c reductase activity
J	0009055	molecular_function	electron transfer activity
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0022904	biological_process	respiratory electron transport chain
J	0045275	cellular_component	respiratory chain complex III
J	0045333	biological_process	cellular respiration
J	1902600	biological_process	proton transmembrane transport
K	0004222	molecular_function	metalloendopeptidase activity
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0006119	biological_process	oxidative phosphorylation
K	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
K	0006508	biological_process	proteolysis
K	0009060	biological_process	aerobic respiration
K	0045275	cellular_component	respiratory chain complex III
K	0045333	biological_process	cellular respiration
K	0046872	molecular_function	metal ion binding
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0006119	biological_process	oxidative phosphorylation
L	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
L	0008121	molecular_function	quinol-cytochrome-c reductase activity
L	0009060	biological_process	aerobic respiration
L	0014823	biological_process	response to activity
L	0017087	cellular_component	mitochondrial processing peptidase complex
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0043279	biological_process	response to alkaloid
L	0044877	molecular_function	protein-containing complex binding
L	0045275	cellular_component	respiratory chain complex III
L	0045333	biological_process	cellular respiration
L	0046872	molecular_function	metal ion binding
L	0098803	cellular_component	respiratory chain complex
L	1902600	biological_process	proton transmembrane transport
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
N	0021539	biological_process	subthalamus development
N	0021548	biological_process	pons development
N	0021680	biological_process	cerebellar Purkinje cell layer development
N	0021766	biological_process	hippocampus development
N	0021794	biological_process	thalamus development
N	0021854	biological_process	hypothalamus development
N	0021860	biological_process	pyramidal neuron development
N	0030901	biological_process	midbrain development
N	0045275	cellular_component	respiratory chain complex III
N	0045333	biological_process	cellular respiration
O	0005515	molecular_function	protein binding
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005759	cellular_component	mitochondrial matrix
O	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
O	0008121	molecular_function	quinol-cytochrome-c reductase activity
O	0016020	cellular_component	membrane
O	0016491	molecular_function	oxidoreductase activity
O	0022904	biological_process	respiratory electron transport chain
O	0031966	cellular_component	mitochondrial membrane
O	0034551	biological_process	mitochondrial respiratory chain complex III assembly
O	0045275	cellular_component	respiratory chain complex III
O	0051537	molecular_function	2 iron, 2 sulfur cluster binding
O	1902600	biological_process	proton transmembrane transport
P	0005515	molecular_function	protein binding
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005759	cellular_component	mitochondrial matrix
P	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
P	0008121	molecular_function	quinol-cytochrome-c reductase activity
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0022904	biological_process	respiratory electron transport chain
P	0031966	cellular_component	mitochondrial membrane
P	0034551	biological_process	mitochondrial respiratory chain complex III assembly
P	0045275	cellular_component	respiratory chain complex III
P	0051537	molecular_function	2 iron, 2 sulfur cluster binding
P	1902600	biological_process	proton transmembrane transport
Q	0005515	molecular_function	protein binding
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Q	0008121	molecular_function	quinol-cytochrome-c reductase activity
Q	0045275	cellular_component	respiratory chain complex III
Q	0045333	biological_process	cellular respiration
Q	1902600	biological_process	proton transmembrane transport
R	0005515	molecular_function	protein binding
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0006119	biological_process	oxidative phosphorylation
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0008121	molecular_function	quinol-cytochrome-c reductase activity
R	0009060	biological_process	aerobic respiration
R	0045275	cellular_component	respiratory chain complex III
R	0045333	biological_process	cellular respiration
R	0098803	cellular_component	respiratory chain complex
R	1902600	biological_process	proton transmembrane transport
S	0005515	molecular_function	protein binding
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0006119	biological_process	oxidative phosphorylation
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
S	0009060	biological_process	aerobic respiration
S	0045275	cellular_component	respiratory chain complex III
S	0045333	biological_process	cellular respiration
S	0098803	cellular_component	respiratory chain complex
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0006091	biological_process	generation of precursor metabolites and energy
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0009055	molecular_function	electron transfer activity
T	0045275	cellular_component	respiratory chain complex III
T	0045333	biological_process	cellular respiration
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0008121	molecular_function	quinol-cytochrome-c reductase activity
U	0009055	molecular_function	electron transfer activity
U	0016020	cellular_component	membrane
U	0020037	molecular_function	heme binding
U	0033762	biological_process	response to glucagon
U	0045275	cellular_component	respiratory chain complex III
U	0045333	biological_process	cellular respiration
U	1902600	biological_process	proton transmembrane transport
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
V	0008121	molecular_function	quinol-cytochrome-c reductase activity
V	0009055	molecular_function	electron transfer activity
V	0016020	cellular_component	membrane
V	0016491	molecular_function	oxidoreductase activity
V	0022904	biological_process	respiratory electron transport chain
V	0045275	cellular_component	respiratory chain complex III
V	0045333	biological_process	cellular respiration
V	1902600	biological_process	proton transmembrane transport
W	0004222	molecular_function	metalloendopeptidase activity
W	0005515	molecular_function	protein binding
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0006119	biological_process	oxidative phosphorylation
W	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
W	0006508	biological_process	proteolysis
W	0009060	biological_process	aerobic respiration
W	0045275	cellular_component	respiratory chain complex III
W	0045333	biological_process	cellular respiration
W	0046872	molecular_function	metal ion binding
Y	0005515	molecular_function	protein binding
Y	0005739	cellular_component	mitochondrion
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0006119	biological_process	oxidative phosphorylation
Y	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Y	0008121	molecular_function	quinol-cytochrome-c reductase activity
Y	0009060	biological_process	aerobic respiration
Y	0014823	biological_process	response to activity
Y	0017087	cellular_component	mitochondrial processing peptidase complex
Y	0031625	molecular_function	ubiquitin protein ligase binding
Y	0043279	biological_process	response to alkaloid
Y	0044877	molecular_function	protein-containing complex binding
Y	0045275	cellular_component	respiratory chain complex III
Y	0045333	biological_process	cellular respiration
Y	0046872	molecular_function	metal ion binding
Y	0098803	cellular_component	respiratory chain complex
Y	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryedfsnlGtTHLLRLTsSlTT

Chain	Residue	Details
K	GLY68-THR91

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	178
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	288
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	581
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CQ69","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13272","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	85
Details	Domain: {"description":"Rieske","evidences":[{"source":"PROSITE-ProRule","id":"PRU00628","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P99028","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9D855","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D855","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	202
Details	Domain: {"description":"Cytochrome c","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Binding site: {"description":"covalent","evidences":[{"source":"UniProtKB","id":"P00125","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XTE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XTH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	322
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"P00157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P00157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DB77","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CZ13","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CZ13","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q68FY0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---