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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9HVF

Native human PPP1R15B-P-eIF2-eIF2B complex

Functional Information from GO Data
ChainGOidnamespacecontents
B0000423biological_processmitophagy
B0003723molecular_functionRNA binding
B0003743molecular_functiontranslation initiation factor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005850cellular_componenteukaryotic translation initiation factor 2 complex
B0006412biological_processtranslation
B0006413biological_processtranslational initiation
B0006417biological_processregulation of translation
B0006446biological_processregulation of translational initiation
B0010494cellular_componentcytoplasmic stress granule
B0016020cellular_componentmembrane
B0032057biological_processnegative regulation of translational initiation in response to stress
B0033290cellular_componenteukaryotic 48S preinitiation complex
B0034063biological_processstress granule assembly
B0034198biological_processcellular response to amino acid starvation
B0034599biological_processcellular response to oxidative stress
B0034605biological_processcellular response to heat
B0034644biological_processcellular response to UV
B0034976biological_processresponse to endoplasmic reticulum stress
B0036490biological_processregulation of translation in response to endoplasmic reticulum stress
B0036499biological_processPERK-mediated unfolded protein response
B0043022molecular_functionribosome binding
B0044207cellular_componenttranslation initiation ternary complex
B0045202cellular_componentsynapse
B0070062cellular_componentextracellular exosome
B0097451cellular_componentglial limiting end-foot
B0140468biological_processHRI-mediated signaling
B0160296molecular_functioncap-dependent translation initiation factor activity
B0160297molecular_functionIRES-mediated translation initiation factor activity
B1904373biological_processresponse to kainic acid
B1990737biological_processresponse to manganese-induced endoplasmic reticulum stress
B2000676biological_processpositive regulation of type B pancreatic cell apoptotic process
C0001731biological_processformation of translation preinitiation complex
C0002183biological_processcytoplasmic translational initiation
C0003723molecular_functionRNA binding
C0003729molecular_functionmRNA binding
C0003743molecular_functiontranslation initiation factor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005850cellular_componenteukaryotic translation initiation factor 2 complex
C0006412biological_processtranslation
C0006413biological_processtranslational initiation
C0006446biological_processregulation of translational initiation
C0008135molecular_functiontranslation factor activity, RNA binding
C0008270molecular_functionzinc ion binding
C0031369molecular_functiontranslation initiation factor binding
C0045202cellular_componentsynapse
C0046872molecular_functionmetal ion binding
D0000049molecular_functiontRNA binding
D0000166molecular_functionnucleotide binding
D0001731biological_processformation of translation preinitiation complex
D0002183biological_processcytoplasmic translational initiation
D0003743molecular_functiontranslation initiation factor activity
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005850cellular_componenteukaryotic translation initiation factor 2 complex
D0006412biological_processtranslation
D0006413biological_processtranslational initiation
D0006446biological_processregulation of translational initiation
D0008135molecular_functiontranslation factor activity, RNA binding
D0016787molecular_functionhydrolase activity
D0045296molecular_functioncadherin binding
D0070062cellular_componentextracellular exosome
D1990856molecular_functionmethionyl-initiator methionine tRNA binding
E0002183biological_processcytoplasmic translational initiation
E0003743molecular_functiontranslation initiation factor activity
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005851cellular_componenteukaryotic translation initiation factor 2B complex
E0006412biological_processtranslation
E0006413biological_processtranslational initiation
E0007417biological_processcentral nervous system development
E0008135molecular_functiontranslation factor activity, RNA binding
E0009408biological_processresponse to heat
E0009749biological_processresponse to glucose
E0014003biological_processoligodendrocyte development
E0043434biological_processresponse to peptide hormone
E0045948biological_processpositive regulation of translational initiation
E0050852biological_processT cell receptor signaling pathway
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues209
DetailsDomain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues7
DetailsRegion: {"description":"G1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsRegion: {"description":"G2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsRegion: {"description":"G3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsRegion: {"description":"G4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsRegion: {"description":"G5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues12
DetailsRegion: {"description":"Interacts with CDC123","evidences":[{"source":"PubMed","id":"35031321","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P32481","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9Z0N1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues22
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues9
DetailsCompositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2026-01-21

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