9HPE

The NTD dimer and the interfacing LBD region of the AMPAR complex GluA3- TARP gamma2 in the apo state

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001540	molecular_function	amyloid-beta binding
B	0001919	biological_process	regulation of receptor recycling
B	0004970	molecular_function	glutamate-gated receptor activity
B	0004971	molecular_function	AMPA glutamate receptor activity
B	0005245	molecular_function	voltage-gated calcium channel activity
B	0005246	molecular_function	calcium channel regulator activity
B	0005262	molecular_function	calcium channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006612	biological_process	protein targeting to membrane
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0007528	biological_process	neuromuscular junction development
B	0008328	cellular_component	ionotropic glutamate receptor complex
B	0009986	cellular_component	cell surface
B	0010226	biological_process	response to lithium ion
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0016247	molecular_function	channel regulator activity
B	0019226	biological_process	transmission of nerve impulse
B	0019722	biological_process	calcium-mediated signaling
B	0022849	molecular_function	glutamate-gated calcium ion channel activity
B	0030425	cellular_component	dendrite
B	0032279	cellular_component	asymmetric synapse
B	0032281	cellular_component	AMPA glutamate receptor complex
B	0032991	cellular_component	protein-containing complex
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034702	cellular_component	monoatomic ion channel complex
B	0035235	biological_process	ionotropic glutamate receptor signaling pathway
B	0035249	biological_process	synaptic transmission, glutamatergic
B	0035255	molecular_function	ionotropic glutamate receptor binding
B	0036477	cellular_component	somatodendritic compartment
B	0042391	biological_process	regulation of membrane potential
B	0042734	cellular_component	presynaptic membrane
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0043083	cellular_component	synaptic cleft
B	0043195	cellular_component	terminal bouton
B	0043197	cellular_component	dendritic spine
B	0043198	cellular_component	dendritic shaft
B	0043204	cellular_component	perikaryon
B	0044300	cellular_component	cerebellar mossy fiber
B	0045202	cellular_component	synapse
B	0045211	cellular_component	postsynaptic membrane
B	0048787	cellular_component	presynaptic active zone membrane
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0050877	biological_process	nervous system process
B	0051289	biological_process	protein homotetramerization
B	0051290	biological_process	protein heterotetramerization
B	0051592	biological_process	response to calcium ion
B	0051899	biological_process	membrane depolarization
B	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
B	0060078	biological_process	regulation of postsynaptic membrane potential
B	0060081	biological_process	membrane hyperpolarization
B	0060082	biological_process	eye blink reflex
B	0060291	biological_process	long-term synaptic potentiation
B	0060992	biological_process	response to fungicide
B	0070588	biological_process	calcium ion transmembrane transport
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
B	0098688	cellular_component	parallel fiber to Purkinje cell synapse
B	0098839	cellular_component	postsynaptic density membrane
B	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
B	0098978	cellular_component	glutamatergic synapse
B	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
B	0099505	biological_process	regulation of presynaptic membrane potential
B	0099507	molecular_function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B	0099604	molecular_function	ligand-gated calcium channel activity
B	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
B	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
B	1905430	biological_process	cellular response to glycine
B	2000311	biological_process	regulation of AMPA receptor activity
B	2000969	biological_process	positive regulation of AMPA receptor activity
C	0001540	molecular_function	amyloid-beta binding
C	0001919	biological_process	regulation of receptor recycling
C	0004970	molecular_function	glutamate-gated receptor activity
C	0004971	molecular_function	AMPA glutamate receptor activity
C	0005245	molecular_function	voltage-gated calcium channel activity
C	0005246	molecular_function	calcium channel regulator activity
C	0005262	molecular_function	calcium channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006612	biological_process	protein targeting to membrane
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0007528	biological_process	neuromuscular junction development
C	0008328	cellular_component	ionotropic glutamate receptor complex
C	0009986	cellular_component	cell surface
C	0010226	biological_process	response to lithium ion
C	0014069	cellular_component	postsynaptic density
C	0016020	cellular_component	membrane
C	0016247	molecular_function	channel regulator activity
C	0019226	biological_process	transmission of nerve impulse
C	0019722	biological_process	calcium-mediated signaling
C	0022849	molecular_function	glutamate-gated calcium ion channel activity
C	0030425	cellular_component	dendrite
C	0032279	cellular_component	asymmetric synapse
C	0032281	cellular_component	AMPA glutamate receptor complex
C	0032991	cellular_component	protein-containing complex
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0035235	biological_process	ionotropic glutamate receptor signaling pathway
C	0035249	biological_process	synaptic transmission, glutamatergic
C	0035255	molecular_function	ionotropic glutamate receptor binding
C	0036477	cellular_component	somatodendritic compartment
C	0042391	biological_process	regulation of membrane potential
C	0042734	cellular_component	presynaptic membrane
C	0043005	cellular_component	neuron projection
C	0043025	cellular_component	neuronal cell body
C	0043083	cellular_component	synaptic cleft
C	0043195	cellular_component	terminal bouton
C	0043197	cellular_component	dendritic spine
C	0043198	cellular_component	dendritic shaft
C	0043204	cellular_component	perikaryon
C	0044300	cellular_component	cerebellar mossy fiber
C	0045202	cellular_component	synapse
C	0045211	cellular_component	postsynaptic membrane
C	0048787	cellular_component	presynaptic active zone membrane
C	0050804	biological_process	modulation of chemical synaptic transmission
C	0050877	biological_process	nervous system process
C	0051289	biological_process	protein homotetramerization
C	0051290	biological_process	protein heterotetramerization
C	0051592	biological_process	response to calcium ion
C	0051899	biological_process	membrane depolarization
C	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
C	0060078	biological_process	regulation of postsynaptic membrane potential
C	0060081	biological_process	membrane hyperpolarization
C	0060082	biological_process	eye blink reflex
C	0060291	biological_process	long-term synaptic potentiation
C	0060992	biological_process	response to fungicide
C	0070588	biological_process	calcium ion transmembrane transport
C	0098685	cellular_component	Schaffer collateral - CA1 synapse
C	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
C	0098688	cellular_component	parallel fiber to Purkinje cell synapse
C	0098839	cellular_component	postsynaptic density membrane
C	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
C	0098978	cellular_component	glutamatergic synapse
C	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
C	0099505	biological_process	regulation of presynaptic membrane potential
C	0099507	molecular_function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C	0099604	molecular_function	ligand-gated calcium channel activity
C	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
C	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
C	1905430	biological_process	cellular response to glycine
C	2000311	biological_process	regulation of AMPA receptor activity
C	2000969	biological_process	positive regulation of AMPA receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21317871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24090084","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21317871","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19003990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20199107","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3DLN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3M3K","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---