9HFQ
Cryo-EM structure of human CDADC1 inactive mutant (E400A): trimer without a ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004126 | molecular_function | cytidine deaminase activity |
| A | 0004132 | molecular_function | dCMP deaminase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006229 | biological_process | dUTP biosynthetic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008829 | molecular_function | dCTP deaminase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0061676 | molecular_function | importin-alpha family protein binding |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0070383 | biological_process | DNA cytosine deamination |
| B | 0004126 | molecular_function | cytidine deaminase activity |
| B | 0004132 | molecular_function | dCMP deaminase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006229 | biological_process | dUTP biosynthetic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008829 | molecular_function | dCTP deaminase activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0061676 | molecular_function | importin-alpha family protein binding |
| B | 0070207 | biological_process | protein homotrimerization |
| B | 0070383 | biological_process | DNA cytosine deamination |
| C | 0004126 | molecular_function | cytidine deaminase activity |
| C | 0004132 | molecular_function | dCMP deaminase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006229 | biological_process | dUTP biosynthetic process |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0008829 | molecular_function | dCTP deaminase activity |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0061676 | molecular_function | importin-alpha family protein binding |
| C | 0070207 | biological_process | protein homotrimerization |
| C | 0070383 | biological_process | DNA cytosine deamination |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | Motif: {"description":"Nuclear export signal","evidences":[{"source":"PubMed","id":"26945630","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"40324085","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"40324085","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9HFQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9HFR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9HFS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9HFT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"40324085","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9HFQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9HFR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9HFS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9HFT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"40324085","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9HFS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
