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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9HEO

Open-state RyR1 in 0.05% POPC micelles, in complex with a nanobody and FKBP

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003151biological_processoutflow tract morphogenesis
A0005219molecular_functionryanodine-sensitive calcium-release channel activity
A0005245molecular_functionvoltage-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005790cellular_componentsmooth endoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006936biological_processmuscle contraction
A0006941biological_processstriated muscle contraction
A0008144molecular_functionobsolete drug binding
A0014802cellular_componentterminal cisterna
A0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0015278molecular_functionintracellularly gated calcium channel activity
A0015643molecular_functiontoxic substance binding
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0030018cellular_componentZ disc
A0031090cellular_componentorganelle membrane
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034704cellular_componentcalcium channel complex
A0035381molecular_functionATP-gated ion channel activity
A0042383cellular_componentsarcolemma
A0042802molecular_functionidentical protein binding
A0043588biological_processskin development
A0043931biological_processossification involved in bone maturation
A0044325molecular_functiontransmembrane transporter binding
A0046872molecular_functionmetal ion binding
A0048741biological_processskeletal muscle fiber development
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0070588biological_processcalcium ion transmembrane transport
A0071277biological_processcellular response to calcium ion
A0071313biological_processcellular response to caffeine
A0097718molecular_functiondisordered domain specific binding
A1990425cellular_componentryanodine receptor complex
C0000166molecular_functionnucleotide binding
C0003151biological_processoutflow tract morphogenesis
C0005219molecular_functionryanodine-sensitive calcium-release channel activity
C0005245molecular_functionvoltage-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005790cellular_componentsmooth endoplasmic reticulum
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006936biological_processmuscle contraction
C0006941biological_processstriated muscle contraction
C0008144molecular_functionobsolete drug binding
C0014802cellular_componentterminal cisterna
C0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0015278molecular_functionintracellularly gated calcium channel activity
C0015643molecular_functiontoxic substance binding
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0030018cellular_componentZ disc
C0031090cellular_componentorganelle membrane
C0033017cellular_componentsarcoplasmic reticulum membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034704cellular_componentcalcium channel complex
C0035381molecular_functionATP-gated ion channel activity
C0042383cellular_componentsarcolemma
C0042802molecular_functionidentical protein binding
C0043588biological_processskin development
C0043931biological_processossification involved in bone maturation
C0044325molecular_functiontransmembrane transporter binding
C0046872molecular_functionmetal ion binding
C0048741biological_processskeletal muscle fiber development
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0070588biological_processcalcium ion transmembrane transport
C0071277biological_processcellular response to calcium ion
C0071313biological_processcellular response to caffeine
C0097718molecular_functiondisordered domain specific binding
C1990425cellular_componentryanodine receptor complex
E0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0008144molecular_functionobsolete drug binding
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0014802cellular_componentterminal cisterna
E0016529cellular_componentsarcoplasmic reticulum
E0016853molecular_functionisomerase activity
E0033017cellular_componentsarcoplasmic reticulum membrane
E0043231cellular_componentintracellular membrane-bounded organelle
E0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0008144molecular_functionobsolete drug binding
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0014802cellular_componentterminal cisterna
F0016529cellular_componentsarcoplasmic reticulum
F0016853molecular_functionisomerase activity
F0033017cellular_componentsarcoplasmic reticulum membrane
F0043231cellular_componentintracellular membrane-bounded organelle
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
G0000166molecular_functionnucleotide binding
G0003151biological_processoutflow tract morphogenesis
G0005219molecular_functionryanodine-sensitive calcium-release channel activity
G0005245molecular_functionvoltage-gated calcium channel activity
G0005262molecular_functioncalcium channel activity
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005516molecular_functioncalmodulin binding
G0005524molecular_functionATP binding
G0005790cellular_componentsmooth endoplasmic reticulum
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0006816biological_processcalcium ion transport
G0006936biological_processmuscle contraction
G0006941biological_processstriated muscle contraction
G0008144molecular_functionobsolete drug binding
G0014802cellular_componentterminal cisterna
G0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G0015278molecular_functionintracellularly gated calcium channel activity
G0015643molecular_functiontoxic substance binding
G0016020cellular_componentmembrane
G0016529cellular_componentsarcoplasmic reticulum
G0019722biological_processcalcium-mediated signaling
G0030018cellular_componentZ disc
G0031090cellular_componentorganelle membrane
G0033017cellular_componentsarcoplasmic reticulum membrane
G0034220biological_processmonoatomic ion transmembrane transport
G0034704cellular_componentcalcium channel complex
G0035381molecular_functionATP-gated ion channel activity
G0042383cellular_componentsarcolemma
G0042802molecular_functionidentical protein binding
G0043588biological_processskin development
G0043931biological_processossification involved in bone maturation
G0044325molecular_functiontransmembrane transporter binding
G0046872molecular_functionmetal ion binding
G0048741biological_processskeletal muscle fiber development
G0051209biological_processrelease of sequestered calcium ion into cytosol
G0051289biological_processprotein homotetramerization
G0070588biological_processcalcium ion transmembrane transport
G0071277biological_processcellular response to calcium ion
G0071313biological_processcellular response to caffeine
G0097718molecular_functiondisordered domain specific binding
G1990425cellular_componentryanodine receptor complex
I0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0008144molecular_functionobsolete drug binding
I0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
I0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
I0014802cellular_componentterminal cisterna
I0016529cellular_componentsarcoplasmic reticulum
I0016853molecular_functionisomerase activity
I0033017cellular_componentsarcoplasmic reticulum membrane
I0043231cellular_componentintracellular membrane-bounded organelle
I0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
J0000166molecular_functionnucleotide binding
J0003151biological_processoutflow tract morphogenesis
J0005219molecular_functionryanodine-sensitive calcium-release channel activity
J0005245molecular_functionvoltage-gated calcium channel activity
J0005262molecular_functioncalcium channel activity
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005516molecular_functioncalmodulin binding
J0005524molecular_functionATP binding
J0005790cellular_componentsmooth endoplasmic reticulum
J0005886cellular_componentplasma membrane
J0006811biological_processmonoatomic ion transport
J0006816biological_processcalcium ion transport
J0006936biological_processmuscle contraction
J0006941biological_processstriated muscle contraction
J0008144molecular_functionobsolete drug binding
J0014802cellular_componentterminal cisterna
J0014808biological_processrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum
J0015278molecular_functionintracellularly gated calcium channel activity
J0015643molecular_functiontoxic substance binding
J0016020cellular_componentmembrane
J0016529cellular_componentsarcoplasmic reticulum
J0019722biological_processcalcium-mediated signaling
J0030018cellular_componentZ disc
J0031090cellular_componentorganelle membrane
J0033017cellular_componentsarcoplasmic reticulum membrane
J0034220biological_processmonoatomic ion transmembrane transport
J0034704cellular_componentcalcium channel complex
J0035381molecular_functionATP-gated ion channel activity
J0042383cellular_componentsarcolemma
J0042802molecular_functionidentical protein binding
J0043588biological_processskin development
J0043931biological_processossification involved in bone maturation
J0044325molecular_functiontransmembrane transporter binding
J0046872molecular_functionmetal ion binding
J0048741biological_processskeletal muscle fiber development
J0051209biological_processrelease of sequestered calcium ion into cytosol
J0051289biological_processprotein homotetramerization
J0070588biological_processcalcium ion transmembrane transport
J0071277biological_processcellular response to calcium ion
J0071313biological_processcellular response to caffeine
J0097718molecular_functiondisordered domain specific binding
J1990425cellular_componentryanodine receptor complex
L0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
L0005515molecular_functionprotein binding
L0005737cellular_componentcytoplasm
L0008144molecular_functionobsolete drug binding
L0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
L0014802cellular_componentterminal cisterna
L0016529cellular_componentsarcoplasmic reticulum
L0016853molecular_functionisomerase activity
L0033017cellular_componentsarcoplasmic reticulum membrane
L0043231cellular_componentintracellular membrane-bounded organelle
L0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues908
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues168
DetailsTopological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues64
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues76
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25470059","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27468892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues220
DetailsDomain: {"description":"MIR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues180
DetailsDomain: {"description":"MIR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues216
DetailsDomain: {"description":"MIR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues864
DetailsDomain: {"description":"B30.2/SPRY 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00548","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues452
DetailsRepeat: {"description":"1"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues112
DetailsDomain: {"description":"EF-hand","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues44
DetailsRegion: {"description":"Interaction with FKBP1A","evidences":[{"source":"PubMed","id":"26245150","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues24
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"25517095","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27573175","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27662087","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27662087","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5TA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues60
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27662087","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5T9V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TAU","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27662087","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5TAN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"F1LMY4","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P21817","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P21817","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues352
DetailsDomain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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