9HDR
Human LINE-1 ORF2p target-primed reverse transcription complex with EN domain resolved
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000794 | cellular_component | condensed nuclear chromosome |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005940 | cellular_component | septin ring |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| A | 0006310 | biological_process | DNA recombination |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008643 | biological_process | carbohydrate transport |
| A | 0009036 | molecular_function | type II site-specific deoxyribonuclease activity |
| A | 0015768 | biological_process | maltose transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016925 | biological_process | protein sumoylation |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0031386 | molecular_function | protein tag activity |
| A | 0032197 | biological_process | retrotransposition |
| A | 0034061 | molecular_function | DNA polymerase activity |
| A | 0034219 | biological_process | carbohydrate transmembrane transport |
| A | 0034289 | biological_process | detection of maltose stimulus |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042956 | biological_process | maltodextrin transmembrane transport |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0044389 | molecular_function | ubiquitin-like protein ligase binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 0071897 | biological_process | DNA biosynthetic process |
| A | 0090304 | biological_process | nucleic acid metabolic process |
| A | 1901982 | molecular_function | maltose binding |
| A | 1990060 | cellular_component | maltose transport complex |
Functional Information from PROSITE/UniProt
| site_id | PS01037 |
| Number of Residues | 18 |
| Details | SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN |
| Chain | Residue | Details |
| A | PRO-372-ASN-355 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 275 |
| Details | Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Domain: {"description":"DUF1725"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Motif: {"description":"FADD motif","evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17626046","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34554261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V0S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7N8K","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8UW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8UW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38096901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38096902","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8C8J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SXT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
