9HDE

Crystal structure of methionine gamma-lyase (K209Q variant) from Brevibacterium aurantiacum in complex with PLP and alpha-ketobutyrate

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004123	molecular_function	cystathionine gamma-lyase activity
A	0005737	cellular_component	cytoplasm
A	0016829	molecular_function	lyase activity
A	0016846	molecular_function	carbon-sulfur lyase activity
A	0018826	molecular_function	methionine gamma-lyase activity
A	0019343	biological_process	cysteine biosynthetic process via cystathionine
A	0019346	biological_process	transsulfuration
A	0030170	molecular_function	pyridoxal phosphate binding
A	0047982	molecular_function	homocysteine desulfhydrase activity
B	0003824	molecular_function	catalytic activity
B	0004123	molecular_function	cystathionine gamma-lyase activity
B	0005737	cellular_component	cytoplasm
B	0016829	molecular_function	lyase activity
B	0016846	molecular_function	carbon-sulfur lyase activity
B	0018826	molecular_function	methionine gamma-lyase activity
B	0019343	biological_process	cysteine biosynthetic process via cystathionine
B	0019346	biological_process	transsulfuration
B	0030170	molecular_function	pyridoxal phosphate binding
B	0047982	molecular_function	homocysteine desulfhydrase activity
C	0003824	molecular_function	catalytic activity
C	0004123	molecular_function	cystathionine gamma-lyase activity
C	0005737	cellular_component	cytoplasm
C	0016829	molecular_function	lyase activity
C	0016846	molecular_function	carbon-sulfur lyase activity
C	0018826	molecular_function	methionine gamma-lyase activity
C	0019343	biological_process	cysteine biosynthetic process via cystathionine
C	0019346	biological_process	transsulfuration
C	0030170	molecular_function	pyridoxal phosphate binding
C	0047982	molecular_function	homocysteine desulfhydrase activity
D	0003824	molecular_function	catalytic activity
D	0004123	molecular_function	cystathionine gamma-lyase activity
D	0005737	cellular_component	cytoplasm
D	0016829	molecular_function	lyase activity
D	0016846	molecular_function	carbon-sulfur lyase activity
D	0018826	molecular_function	methionine gamma-lyase activity
D	0019343	biological_process	cysteine biosynthetic process via cystathionine
D	0019346	biological_process	transsulfuration
D	0030170	molecular_function	pyridoxal phosphate binding
D	0047982	molecular_function	homocysteine desulfhydrase activity
E	0003824	molecular_function	catalytic activity
E	0004123	molecular_function	cystathionine gamma-lyase activity
E	0005737	cellular_component	cytoplasm
E	0016829	molecular_function	lyase activity
E	0016846	molecular_function	carbon-sulfur lyase activity
E	0018826	molecular_function	methionine gamma-lyase activity
E	0019343	biological_process	cysteine biosynthetic process via cystathionine
E	0019346	biological_process	transsulfuration
E	0030170	molecular_function	pyridoxal phosphate binding
E	0047982	molecular_function	homocysteine desulfhydrase activity
F	0003824	molecular_function	catalytic activity
F	0004123	molecular_function	cystathionine gamma-lyase activity
F	0005737	cellular_component	cytoplasm
F	0016829	molecular_function	lyase activity
F	0016846	molecular_function	carbon-sulfur lyase activity
F	0018826	molecular_function	methionine gamma-lyase activity
F	0019343	biological_process	cysteine biosynthetic process via cystathionine
F	0019346	biological_process	transsulfuration
F	0030170	molecular_function	pyridoxal phosphate binding
F	0047982	molecular_function	homocysteine desulfhydrase activity
G	0003824	molecular_function	catalytic activity
G	0004123	molecular_function	cystathionine gamma-lyase activity
G	0005737	cellular_component	cytoplasm
G	0016829	molecular_function	lyase activity
G	0016846	molecular_function	carbon-sulfur lyase activity
G	0018826	molecular_function	methionine gamma-lyase activity
G	0019343	biological_process	cysteine biosynthetic process via cystathionine
G	0019346	biological_process	transsulfuration
G	0030170	molecular_function	pyridoxal phosphate binding
G	0047982	molecular_function	homocysteine desulfhydrase activity
H	0003824	molecular_function	catalytic activity
H	0004123	molecular_function	cystathionine gamma-lyase activity
H	0005737	cellular_component	cytoplasm
H	0016829	molecular_function	lyase activity
H	0016846	molecular_function	carbon-sulfur lyase activity
H	0018826	molecular_function	methionine gamma-lyase activity
H	0019343	biological_process	cysteine biosynthetic process via cystathionine
H	0019346	biological_process	transsulfuration
H	0030170	molecular_function	pyridoxal phosphate binding
H	0047982	molecular_function	homocysteine desulfhydrase activity
I	0003824	molecular_function	catalytic activity
I	0004123	molecular_function	cystathionine gamma-lyase activity
I	0005737	cellular_component	cytoplasm
I	0016829	molecular_function	lyase activity
I	0016846	molecular_function	carbon-sulfur lyase activity
I	0018826	molecular_function	methionine gamma-lyase activity
I	0019343	biological_process	cysteine biosynthetic process via cystathionine
I	0019346	biological_process	transsulfuration
I	0030170	molecular_function	pyridoxal phosphate binding
I	0047982	molecular_function	homocysteine desulfhydrase activity
J	0003824	molecular_function	catalytic activity
J	0004123	molecular_function	cystathionine gamma-lyase activity
J	0005737	cellular_component	cytoplasm
J	0016829	molecular_function	lyase activity
J	0016846	molecular_function	carbon-sulfur lyase activity
J	0018826	molecular_function	methionine gamma-lyase activity
J	0019343	biological_process	cysteine biosynthetic process via cystathionine
J	0019346	biological_process	transsulfuration
J	0030170	molecular_function	pyridoxal phosphate binding
J	0047982	molecular_function	homocysteine desulfhydrase activity
K	0003824	molecular_function	catalytic activity
K	0004123	molecular_function	cystathionine gamma-lyase activity
K	0005737	cellular_component	cytoplasm
K	0016829	molecular_function	lyase activity
K	0016846	molecular_function	carbon-sulfur lyase activity
K	0018826	molecular_function	methionine gamma-lyase activity
K	0019343	biological_process	cysteine biosynthetic process via cystathionine
K	0019346	biological_process	transsulfuration
K	0030170	molecular_function	pyridoxal phosphate binding
K	0047982	molecular_function	homocysteine desulfhydrase activity
L	0003824	molecular_function	catalytic activity
L	0004123	molecular_function	cystathionine gamma-lyase activity
L	0005737	cellular_component	cytoplasm
L	0016829	molecular_function	lyase activity
L	0016846	molecular_function	carbon-sulfur lyase activity
L	0018826	molecular_function	methionine gamma-lyase activity
L	0019343	biological_process	cysteine biosynthetic process via cystathionine
L	0019346	biological_process	transsulfuration
L	0030170	molecular_function	pyridoxal phosphate binding
L	0047982	molecular_function	homocysteine desulfhydrase activity
M	0003824	molecular_function	catalytic activity
M	0004123	molecular_function	cystathionine gamma-lyase activity
M	0005737	cellular_component	cytoplasm
M	0016829	molecular_function	lyase activity
M	0016846	molecular_function	carbon-sulfur lyase activity
M	0018826	molecular_function	methionine gamma-lyase activity
M	0019343	biological_process	cysteine biosynthetic process via cystathionine
M	0019346	biological_process	transsulfuration
M	0030170	molecular_function	pyridoxal phosphate binding
M	0047982	molecular_function	homocysteine desulfhydrase activity
N	0003824	molecular_function	catalytic activity
N	0004123	molecular_function	cystathionine gamma-lyase activity
N	0005737	cellular_component	cytoplasm
N	0016829	molecular_function	lyase activity
N	0016846	molecular_function	carbon-sulfur lyase activity
N	0018826	molecular_function	methionine gamma-lyase activity
N	0019343	biological_process	cysteine biosynthetic process via cystathionine
N	0019346	biological_process	transsulfuration
N	0030170	molecular_function	pyridoxal phosphate binding
N	0047982	molecular_function	homocysteine desulfhydrase activity
O	0003824	molecular_function	catalytic activity
O	0004123	molecular_function	cystathionine gamma-lyase activity
O	0005737	cellular_component	cytoplasm
O	0016829	molecular_function	lyase activity
O	0016846	molecular_function	carbon-sulfur lyase activity
O	0018826	molecular_function	methionine gamma-lyase activity
O	0019343	biological_process	cysteine biosynthetic process via cystathionine
O	0019346	biological_process	transsulfuration
O	0030170	molecular_function	pyridoxal phosphate binding
O	0047982	molecular_function	homocysteine desulfhydrase activity
P	0003824	molecular_function	catalytic activity
P	0004123	molecular_function	cystathionine gamma-lyase activity
P	0005737	cellular_component	cytoplasm
P	0016829	molecular_function	lyase activity
P	0016846	molecular_function	carbon-sulfur lyase activity
P	0018826	molecular_function	methionine gamma-lyase activity
P	0019343	biological_process	cysteine biosynthetic process via cystathionine
P	0019346	biological_process	transsulfuration
P	0030170	molecular_function	pyridoxal phosphate binding
P	0047982	molecular_function	homocysteine desulfhydrase activity
Q	0003824	molecular_function	catalytic activity
Q	0004123	molecular_function	cystathionine gamma-lyase activity
Q	0005737	cellular_component	cytoplasm
Q	0016829	molecular_function	lyase activity
Q	0016846	molecular_function	carbon-sulfur lyase activity
Q	0018826	molecular_function	methionine gamma-lyase activity
Q	0019343	biological_process	cysteine biosynthetic process via cystathionine
Q	0019346	biological_process	transsulfuration
Q	0030170	molecular_function	pyridoxal phosphate binding
Q	0047982	molecular_function	homocysteine desulfhydrase activity
R	0003824	molecular_function	catalytic activity
R	0004123	molecular_function	cystathionine gamma-lyase activity
R	0005737	cellular_component	cytoplasm
R	0016829	molecular_function	lyase activity
R	0016846	molecular_function	carbon-sulfur lyase activity
R	0018826	molecular_function	methionine gamma-lyase activity
R	0019343	biological_process	cysteine biosynthetic process via cystathionine
R	0019346	biological_process	transsulfuration
R	0030170	molecular_function	pyridoxal phosphate binding
R	0047982	molecular_function	homocysteine desulfhydrase activity
S	0003824	molecular_function	catalytic activity
S	0004123	molecular_function	cystathionine gamma-lyase activity
S	0005737	cellular_component	cytoplasm
S	0016829	molecular_function	lyase activity
S	0016846	molecular_function	carbon-sulfur lyase activity
S	0018826	molecular_function	methionine gamma-lyase activity
S	0019343	biological_process	cysteine biosynthetic process via cystathionine
S	0019346	biological_process	transsulfuration
S	0030170	molecular_function	pyridoxal phosphate binding
S	0047982	molecular_function	homocysteine desulfhydrase activity
T	0003824	molecular_function	catalytic activity
T	0004123	molecular_function	cystathionine gamma-lyase activity
T	0005737	cellular_component	cytoplasm
T	0016829	molecular_function	lyase activity
T	0016846	molecular_function	carbon-sulfur lyase activity
T	0018826	molecular_function	methionine gamma-lyase activity
T	0019343	biological_process	cysteine biosynthetic process via cystathionine
T	0019346	biological_process	transsulfuration
T	0030170	molecular_function	pyridoxal phosphate binding
T	0047982	molecular_function	homocysteine desulfhydrase activity
U	0003824	molecular_function	catalytic activity
U	0004123	molecular_function	cystathionine gamma-lyase activity
U	0005737	cellular_component	cytoplasm
U	0016829	molecular_function	lyase activity
U	0016846	molecular_function	carbon-sulfur lyase activity
U	0018826	molecular_function	methionine gamma-lyase activity
U	0019343	biological_process	cysteine biosynthetic process via cystathionine
U	0019346	biological_process	transsulfuration
U	0030170	molecular_function	pyridoxal phosphate binding
U	0047982	molecular_function	homocysteine desulfhydrase activity
V	0003824	molecular_function	catalytic activity
V	0004123	molecular_function	cystathionine gamma-lyase activity
V	0005737	cellular_component	cytoplasm
V	0016829	molecular_function	lyase activity
V	0016846	molecular_function	carbon-sulfur lyase activity
V	0018826	molecular_function	methionine gamma-lyase activity
V	0019343	biological_process	cysteine biosynthetic process via cystathionine
V	0019346	biological_process	transsulfuration
V	0030170	molecular_function	pyridoxal phosphate binding
V	0047982	molecular_function	homocysteine desulfhydrase activity
W	0003824	molecular_function	catalytic activity
W	0004123	molecular_function	cystathionine gamma-lyase activity
W	0005737	cellular_component	cytoplasm
W	0016829	molecular_function	lyase activity
W	0016846	molecular_function	carbon-sulfur lyase activity
W	0018826	molecular_function	methionine gamma-lyase activity
W	0019343	biological_process	cysteine biosynthetic process via cystathionine
W	0019346	biological_process	transsulfuration
W	0030170	molecular_function	pyridoxal phosphate binding
W	0047982	molecular_function	homocysteine desulfhydrase activity
X	0003824	molecular_function	catalytic activity
X	0004123	molecular_function	cystathionine gamma-lyase activity
X	0005737	cellular_component	cytoplasm
X	0016829	molecular_function	lyase activity
X	0016846	molecular_function	carbon-sulfur lyase activity
X	0018826	molecular_function	methionine gamma-lyase activity
X	0019343	biological_process	cysteine biosynthetic process via cystathionine
X	0019346	biological_process	transsulfuration
X	0030170	molecular_function	pyridoxal phosphate binding
X	0047982	molecular_function	homocysteine desulfhydrase activity

Functional Information from PROSITE/UniProt

site_id	PS00626
Number of Residues	11
Details	RCC1_2 Regulator of chromosome condensation (RCC1) signature 2. VSAGtPHIVAV

Chain	Residue	Details
A	VAL105-VAL115

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13254","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	72
Details	Binding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"P13254","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"UniProtKB","id":"P13254","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---