9H2I

Dihydrolipoyl Dehydrogenase (E3) in complex with the binding domain of Dihydrolipoamide Acetyltransferase (E2) from the E. coli pyruvate dehydrogenase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016746	molecular_function	acyltransferase activity
B	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005960	cellular_component	glycine cleavage complex
B	0006099	biological_process	tricarboxylic acid cycle
B	0006103	biological_process	2-oxoglutarate metabolic process
B	0006730	biological_process	one-carbon metabolic process
B	0006979	biological_process	response to oxidative stress
B	0008270	molecular_function	zinc ion binding
B	0015036	molecular_function	disulfide oxidoreductase activity
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
B	0019464	biological_process	glycine decarboxylation via glycine cleavage system
B	0042802	molecular_function	identical protein binding
B	0042867	biological_process	pyruvate catabolic process
B	0050660	molecular_function	flavin adenine dinucleotide binding
C	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005960	cellular_component	glycine cleavage complex
C	0006099	biological_process	tricarboxylic acid cycle
C	0006103	biological_process	2-oxoglutarate metabolic process
C	0006730	biological_process	one-carbon metabolic process
C	0006979	biological_process	response to oxidative stress
C	0008270	molecular_function	zinc ion binding
C	0015036	molecular_function	disulfide oxidoreductase activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
C	0019464	biological_process	glycine decarboxylation via glycine cleavage system
C	0042802	molecular_function	identical protein binding
C	0042867	biological_process	pyruvate catabolic process
C	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PROSITE/UniProt

site_id	PS00076
Number of Residues	11
Details	PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGvCLnvGCIP

Chain	Residue	Details
B	GLY42-PRO52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	37
Details	Domain: {"description":"Peripheral subunit-binding (PSBD)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01170","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	44
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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