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9GVO

type-I interferons autoantibodies pmab15 and pmab14 in complex with Interferon alpha-2

Functional Information from GO Data
ChainGOidnamespacecontents
B0002250biological_processadaptive immune response
B0002286biological_processT cell activation involved in immune response
B0002312biological_processB cell activation involved in immune response
B0002323biological_processnatural killer cell activation involved in immune response
B0005125molecular_functioncytokine activity
B0005132molecular_functiontype I interferon receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0006959biological_processhumoral immune response
B0007166biological_processcell surface receptor signaling pathway
B0007267biological_processcell-cell signaling
B0010629biological_processnegative regulation of gene expression
B0031012cellular_componentextracellular matrix
B0032696biological_processnegative regulation of interleukin-13 production
B0032714biological_processnegative regulation of interleukin-5 production
B0043330biological_processresponse to exogenous dsRNA
B0045581biological_processnegative regulation of T cell differentiation
B0045892biological_processnegative regulation of DNA-templated transcription
B0046597biological_processhost-mediated suppression of symbiont invasion
B0051607biological_processdefense response to virus
B0060337biological_processtype I interferon-mediated signaling pathway
B0097696biological_processcell surface receptor signaling pathway via STAT
B0098586biological_processcellular response to virus
B2000552biological_processnegative regulation of T-helper 2 cell cytokine production
Functional Information from PROSITE/UniProt
site_idPS00252
Number of Residues19
DetailsINTERFERON_A_B_D Interferon alpha, beta and delta family signature. YFqRItlYLkekkyspCAW
ChainResidueDetails
BTYR122-TRP140

246704

PDB entries from 2025-12-24

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