9GP1
Jumonji domain-containing protein 2A with crystallization epitope mutatios K330R:A334E
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16677698 |
| Chain | Residue | Details |
| A | TYR133 | |
| D | TYR133 | |
| D | ASN199 | |
| D | LYS207 | |
| A | ASN199 | |
| A | LYS207 | |
| B | TYR133 | |
| B | ASN199 | |
| B | LYS207 | |
| C | TYR133 | |
| C | ASN199 | |
| C | LYS207 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 |
| Chain | Residue | Details |
| A | HIS189 | |
| A | HIS277 | |
| B | HIS189 | |
| B | HIS277 | |
| C | HIS189 | |
| C | HIS277 | |
| D | HIS189 | |
| D | HIS277 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16677698, ECO:0000305|PubMed:26741168 |
| Chain | Residue | Details |
| A | GLU191 | |
| B | GLU191 | |
| C | GLU191 | |
| D | GLU191 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0007744|PDB:5F2W, ECO:0007744|PDB:5F32, ECO:0007744|PDB:5F37, ECO:0007744|PDB:5F39, ECO:0007744|PDB:5F3E, ECO:0007744|PDB:5F3G, ECO:0007744|PDB:5F5I |
| Chain | Residue | Details |
| A | CYS235 | |
| C | HIS241 | |
| C | CYS307 | |
| C | CYS309 | |
| D | CYS235 | |
| D | HIS241 | |
| D | CYS307 | |
| D | CYS309 | |
| A | HIS241 | |
| A | CYS307 | |
| A | CYS309 | |
| B | CYS235 | |
| B | HIS241 | |
| B | CYS307 | |
| B | CYS309 | |
| C | CYS235 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:B2RXH2 |
| Chain | Residue | Details |
| A | LYS242 | |
| B | LYS242 | |
| C | LYS242 | |
| D | LYS242 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| A | ALA3 | |
| B | ALA3 | |
| C | ALA3 | |
| D | ALA4 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 370 |
| Chain | Residue | Details |
| A | GLY171 | hydrogen bond acceptor, steric role |
| A | TYR178 | hydrogen bond donor, steric role |
| A | HIS189 | metal ligand |
| A | GLU191 | attractive charge-charge interaction, hydrogen bond acceptor, metal ligand, steric role |
| A | HIS277 | metal ligand |
| A | SER289 | hydrogen bond donor, steric role |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 370 |
| Chain | Residue | Details |
| B | GLY171 | hydrogen bond acceptor, steric role |
| B | TYR178 | hydrogen bond donor, steric role |
| B | HIS189 | metal ligand |
| B | GLU191 | attractive charge-charge interaction, hydrogen bond acceptor, metal ligand, steric role |
| B | HIS277 | metal ligand |
| B | SER289 | hydrogen bond donor, steric role |
| site_id | MCSA3 |
| Number of Residues | 6 |
| Details | M-CSA 370 |
| Chain | Residue | Details |
| C | GLY171 | hydrogen bond acceptor, steric role |
| C | TYR178 | hydrogen bond donor, steric role |
| C | HIS189 | metal ligand |
| C | GLU191 | attractive charge-charge interaction, hydrogen bond acceptor, metal ligand, steric role |
| C | HIS277 | metal ligand |
| C | SER289 | hydrogen bond donor, steric role |
| site_id | MCSA4 |
| Number of Residues | 6 |
| Details | M-CSA 370 |
| Chain | Residue | Details |
| D | GLY171 | hydrogen bond acceptor, steric role |
| D | TYR178 | hydrogen bond donor, steric role |
| D | HIS189 | metal ligand |
| D | GLU191 | attractive charge-charge interaction, hydrogen bond acceptor, metal ligand, steric role |
| D | HIS277 | metal ligand |
| D | SER289 | hydrogen bond donor, steric role |
