Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9GCP

ChREBP/14-3-3 complex stabilized by AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004860	molecular_function	protein kinase inhibitor activity
A	0004864	molecular_function	protein phosphatase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005774	cellular_component	vacuolar membrane
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006605	biological_process	protein targeting
A	0007165	biological_process	signal transduction
A	0008104	biological_process	intracellular protein localization
A	0016020	cellular_component	membrane
A	0017053	cellular_component	transcription repressor complex
A	0019899	molecular_function	enzyme binding
A	0019904	molecular_function	protein domain specific binding
A	0032991	cellular_component	protein-containing complex
A	0035332	biological_process	positive regulation of hippo signaling
A	0042308	biological_process	negative regulation of protein import into nucleus
A	0042470	cellular_component	melanosome
A	0042802	molecular_function	identical protein binding
A	0042826	molecular_function	histone deacetylase binding
A	0044877	molecular_function	protein-containing complex binding
A	0045296	molecular_function	cadherin binding
A	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050815	molecular_function	phosphoserine residue binding
A	0051219	molecular_function	phosphoprotein binding
A	0060243	biological_process	negative regulation of cell growth involved in contact inhibition
A	0070062	cellular_component	extracellular exosome
A	0140311	molecular_function	protein sequestering activity
C	0004860	molecular_function	protein kinase inhibitor activity
C	0004864	molecular_function	protein phosphatase inhibitor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005774	cellular_component	vacuolar membrane
C	0005829	cellular_component	cytosol
C	0005925	cellular_component	focal adhesion
C	0006605	biological_process	protein targeting
C	0007165	biological_process	signal transduction
C	0008104	biological_process	intracellular protein localization
C	0016020	cellular_component	membrane
C	0017053	cellular_component	transcription repressor complex
C	0019899	molecular_function	enzyme binding
C	0019904	molecular_function	protein domain specific binding
C	0032991	cellular_component	protein-containing complex
C	0035332	biological_process	positive regulation of hippo signaling
C	0042308	biological_process	negative regulation of protein import into nucleus
C	0042470	cellular_component	melanosome
C	0042802	molecular_function	identical protein binding
C	0042826	molecular_function	histone deacetylase binding
C	0044877	molecular_function	protein-containing complex binding
C	0045296	molecular_function	cadherin binding
C	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050815	molecular_function	phosphoserine residue binding
C	0051219	molecular_function	phosphoprotein binding
C	0060243	biological_process	negative regulation of cell growth involved in contact inhibition
C	0070062	cellular_component	extracellular exosome
C	0140311	molecular_function	protein sequestering activity
E	0004860	molecular_function	protein kinase inhibitor activity
E	0004864	molecular_function	protein phosphatase inhibitor activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005774	cellular_component	vacuolar membrane
E	0005829	cellular_component	cytosol
E	0005925	cellular_component	focal adhesion
E	0006605	biological_process	protein targeting
E	0007165	biological_process	signal transduction
E	0008104	biological_process	intracellular protein localization
E	0016020	cellular_component	membrane
E	0017053	cellular_component	transcription repressor complex
E	0019899	molecular_function	enzyme binding
E	0019904	molecular_function	protein domain specific binding
E	0032991	cellular_component	protein-containing complex
E	0035332	biological_process	positive regulation of hippo signaling
E	0042308	biological_process	negative regulation of protein import into nucleus
E	0042470	cellular_component	melanosome
E	0042802	molecular_function	identical protein binding
E	0042826	molecular_function	histone deacetylase binding
E	0044877	molecular_function	protein-containing complex binding
E	0045296	molecular_function	cadherin binding
E	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0050815	molecular_function	phosphoserine residue binding
E	0051219	molecular_function	phosphoprotein binding
E	0060243	biological_process	negative regulation of cell growth involved in contact inhibition
E	0070062	cellular_component	extracellular exosome
E	0140311	molecular_function	protein sequestering activity
G	0004860	molecular_function	protein kinase inhibitor activity
G	0004864	molecular_function	protein phosphatase inhibitor activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005774	cellular_component	vacuolar membrane
G	0005829	cellular_component	cytosol
G	0005925	cellular_component	focal adhesion
G	0006605	biological_process	protein targeting
G	0007165	biological_process	signal transduction
G	0008104	biological_process	intracellular protein localization
G	0016020	cellular_component	membrane
G	0017053	cellular_component	transcription repressor complex
G	0019899	molecular_function	enzyme binding
G	0019904	molecular_function	protein domain specific binding
G	0032991	cellular_component	protein-containing complex
G	0035332	biological_process	positive regulation of hippo signaling
G	0042308	biological_process	negative regulation of protein import into nucleus
G	0042470	cellular_component	melanosome
G	0042802	molecular_function	identical protein binding
G	0042826	molecular_function	histone deacetylase binding
G	0044877	molecular_function	protein-containing complex binding
G	0045296	molecular_function	cadherin binding
G	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0050815	molecular_function	phosphoserine residue binding
G	0051219	molecular_function	phosphoprotein binding
G	0060243	biological_process	negative regulation of cell growth involved in contact inhibition
G	0070062	cellular_component	extracellular exosome
G	0140311	molecular_function	protein sequestering activity

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG43-VAL53

site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
A	TYR213-SER232

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Site: {"description":"Interaction with phosphoserine on interacting protein","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P27348","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P27348","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CQV8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"Q9CQV8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P68251","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"P27348","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)