9GCD

CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH Fulacimstat (COMPOUND86)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0002003	biological_process	angiotensin maturation
AAA	0004175	molecular_function	endopeptidase activity
AAA	0004252	molecular_function	serine-type endopeptidase activity
AAA	0005576	cellular_component	extracellular region
AAA	0005615	cellular_component	extracellular space
AAA	0006508	biological_process	proteolysis
AAA	0006518	biological_process	peptide metabolic process
AAA	0008233	molecular_function	peptidase activity
AAA	0008236	molecular_function	serine-type peptidase activity
AAA	0016485	biological_process	protein processing
AAA	0016787	molecular_function	hydrolase activity
AAA	0022617	biological_process	extracellular matrix disassembly
AAA	0030141	cellular_component	secretory granule
AAA	0030163	biological_process	protein catabolic process
AAA	0030901	biological_process	midbrain development
AAA	0031012	cellular_component	extracellular matrix
AAA	0034769	biological_process	basement membrane disassembly
AAA	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
AAA	0042277	molecular_function	peptide binding
AAA	0045766	biological_process	positive regulation of angiogenesis
AAA	0050727	biological_process	regulation of inflammatory response
AAA	0051604	biological_process	protein maturation
AAA	0071333	biological_process	cellular response to glucose stimulus
AAA	0140447	biological_process	cytokine precursor processing

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
AAA	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. SAfkGDSGGPLL

Chain	Residue	Details
AAA	SER189-LEU200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2071582","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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