9G7F
Cryo-EM structure of Acetyl-coenzyme A synthetase (AcsA) dimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003987 | molecular_function | acetyl-CoA synthetase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| A | 0016405 | molecular_function | CoA-ligase activity |
| A | 0016878 | molecular_function | acid-thiol ligase activity |
| A | 0045121 | cellular_component | membrane raft |
| B | 0003987 | molecular_function | acetyl-CoA synthetase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| B | 0016405 | molecular_function | CoA-ligase activity |
| B | 0016878 | molecular_function | acid-thiol ligase activity |
| B | 0045121 | cellular_component | membrane raft |
| C | 0008959 | molecular_function | phosphate acetyltransferase activity |
| C | 0009847 | biological_process | spore germination |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0019152 | molecular_function | acetoin dehydrogenase (NAD+) activity |
| C | 0034078 | biological_process | butanediol catabolic process |
| C | 0043894 | molecular_function | acetyl-CoA synthetase acetyltransferase activity |
| C | 0045014 | biological_process | carbon catabolite repression of transcription by glucose |
| C | 0045150 | biological_process | acetoin catabolic process |
| C | 0061733 | molecular_function | protein-lysine-acetyltransferase activity |
| C | 0140391 | biological_process | negative regulation of acetyl-CoA biosynthesis |
Functional Information from PROSITE/UniProt
| site_id | PS00455 |
| Number of Residues | 12 |
| Details | AMP_BINDING Putative AMP-binding domain signature. LHYTSGSTGtPK |
| Chain | Residue | Details |
| B | LEU211-LYS222 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P27550","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; by AcuA","evidences":[{"source":"PubMed","id":"39019872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40089509","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 141 |
| Details | Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"39019872","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
