9G7F

Cryo-EM structure of Acetyl-coenzyme A synthetase (AcsA) dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003987	molecular_function	acetate-CoA ligase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006085	biological_process	acetyl-CoA biosynthetic process
A	0016020	cellular_component	membrane
A	0016405	molecular_function	CoA-ligase activity
A	0016874	molecular_function	ligase activity
A	0016878	molecular_function	acid-thiol ligase activity
A	0045121	cellular_component	membrane raft
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003987	molecular_function	acetate-CoA ligase activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006085	biological_process	acetyl-CoA biosynthetic process
B	0016020	cellular_component	membrane
B	0016405	molecular_function	CoA-ligase activity
B	0016874	molecular_function	ligase activity
B	0016878	molecular_function	acid-thiol ligase activity
B	0045121	cellular_component	membrane raft
B	0046872	molecular_function	metal ion binding
C	0009847	biological_process	spore germination
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0019152	molecular_function	acetoin dehydrogenase (NAD+) activity
C	0030435	biological_process	sporulation resulting in formation of a cellular spore
C	0034078	biological_process	butanediol catabolic process
C	0043894	molecular_function	acetyl-CoA synthetase acetyltransferase activity
C	0045014	biological_process	carbon catabolite repression of transcription by glucose
C	0045150	biological_process	acetoin catabolic process
C	0071311	biological_process	cellular response to acetate

Functional Information from PROSITE/UniProt

site_id	PS00455
Number of Residues	12
Details	AMP_BINDING Putative AMP-binding domain signature. LHYTSGSTGtPK

Chain	Residue	Details
B	LEU211-LYS222

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
B	THR260
B	ILE482
A	THR260
A	GLY333
A	ASP354
A	ASP440
A	ARG455
A	SER463
A	ARG466
A	VAL477
A	HIS479
B	GLY333
A	ILE482
B	ASP354
B	ASP440
B	ARG455
B	SER463
B	ARG466
B	VAL477
B	HIS479

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
B	LYS524
A	LYS524

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250

Chain	Residue	Details
B	LYS549
A	LYS549

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