9FNO
Cryo-EM structure of human CD163 SRCR1-9 in complex with haptoglobin-hemoglobin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0005344 | molecular_function | oxygen carrier activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005829 | cellular_component | cytosol |
| A | 0005833 | cellular_component | hemoglobin complex |
| A | 0006954 | biological_process | inflammatory response |
| A | 0015670 | biological_process | carbon dioxide transport |
| A | 0015671 | biological_process | oxygen transport |
| A | 0016020 | cellular_component | membrane |
| A | 0019825 | molecular_function | oxygen binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0030185 | biological_process | nitric oxide transport |
| A | 0031720 | molecular_function | haptoglobin binding |
| A | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| A | 0042542 | biological_process | response to hydrogen peroxide |
| A | 0042744 | biological_process | hydrogen peroxide catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048821 | biological_process | erythrocyte development |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071682 | cellular_component | endocytic vesicle lumen |
| A | 0072562 | cellular_component | blood microparticle |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004601 | molecular_function | peroxidase activity |
| B | 0005344 | molecular_function | oxygen carrier activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005829 | cellular_component | cytosol |
| B | 0005833 | cellular_component | hemoglobin complex |
| B | 0006954 | biological_process | inflammatory response |
| B | 0008217 | biological_process | regulation of blood pressure |
| B | 0015670 | biological_process | carbon dioxide transport |
| B | 0015671 | biological_process | oxygen transport |
| B | 0019825 | molecular_function | oxygen binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0030185 | biological_process | nitric oxide transport |
| B | 0030492 | molecular_function | hemoglobin binding |
| B | 0031720 | molecular_function | haptoglobin binding |
| B | 0031721 | molecular_function | hemoglobin alpha binding |
| B | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
| B | 0042542 | biological_process | response to hydrogen peroxide |
| B | 0042744 | biological_process | hydrogen peroxide catabolic process |
| B | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048821 | biological_process | erythrocyte development |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070293 | biological_process | renal absorption |
| B | 0070527 | biological_process | platelet aggregation |
| B | 0071682 | cellular_component | endocytic vesicle lumen |
| B | 0072562 | cellular_component | blood microparticle |
| B | 0097746 | biological_process | blood vessel diameter maintenance |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| B | 1904724 | cellular_component | tertiary granule lumen |
| B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| E | 0016020 | cellular_component | membrane |
| F | 0016020 | cellular_component | membrane |
| G | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00420 |
| Number of Residues | 38 |
| Details | SRCR_1 SRCR domain signature. GenkcsGrvEvkvqeeWGtvCnngWsmeavsviCnqlG |
| Chain | Residue | Details |
| E | GLY56-GLY93 | |
| E | GLY271-GLY308 | |
| E | GLY724-GLY761 | |
| E | GLY934-GLY971 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3024 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| E | SER42-SER1050 | |
| F | SER42-SER1050 | |
| G | SER42-SER1050 | |
| B | HIS143 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| E | PHE1051-LEU1071 | |
| F | PHE1051-LEU1071 | |
| G | PHE1051-LEU1071 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 252 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| E | THR1072-LEU1156 | |
| A | LEU91 | |
| A | LEU106 | |
| A | THR108 | |
| A | VAL121 | |
| A | SER133 | |
| F | THR1072-LEU1156 | |
| G | THR1072-LEU1156 | |
| A | LEU29 | |
| A | HIS45 | |
| A | ASP47 | |
| A | SER52 | |
| A | VAL55 | |
| A | GLY59 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | SITE: Cleavage; in calcium-free condition |
| Chain | Residue | Details |
| E | VAL269 | |
| G | VAL281 | |
| G | VAL333 | |
| G | ASP360 | |
| B | ARG104 | |
| B | LEU110 | |
| B | GLY119 | |
| B | PHE122 | |
| B | ALA128 | |
| B | ALA140 | |
| B | LYS144 | |
| E | VAL281 | |
| E | VAL333 | |
| E | ASP360 | |
| F | VAL269 | |
| F | VAL281 | |
| F | VAL333 | |
| F | ASP360 | |
| G | VAL269 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| E | ASN105 | |
| F | ASN105 | |
| G | ASN105 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| E | ASN140 | |
| E | ASN767 | |
| E | ASN1027 | |
| F | ASN140 | |
| F | ASN767 | |
| F | ASN1027 | |
| G | ASN140 | |
| G | ASN767 | |
| G | ASN1027 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER9 | |
| B | SER44 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | THR12 | |
| B | THR50 | |
| B | THR87 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:4531009 |
| Chain | Residue | Details |
| B | LYS59 | |
| B | LYS82 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 |
| Chain | Residue | Details |
| B | CYS93 | |
| A | SER124 | |
| A | SER131 | |
| A | SER138 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009 |
| Chain | Residue | Details |
| B | LYS144 | |
| A | THR134 | |
| A | THR137 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 |
| Chain | Residue | Details |
| B | VAL1 | |
| A | LYS16 | |
| A | LYS40 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 |
| Chain | Residue | Details |
| B | LYS8 | |
| B | LYS17 | |
| B | LYS66 | |
| B | LYS120 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733 |
| Chain | Residue | Details |
| B | LYS144 |
