9FML

Aerolysin heptamer in membrane inserted form reconstituted in amphipoles.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001897	biological_process	symbiont-mediated cytolysis of host cell
A	0005576	cellular_component	extracellular region
A	0020002	cellular_component	host cell plasma membrane
A	0035821	biological_process	modulation of process of another organism
A	0042802	molecular_function	identical protein binding
A	0090729	molecular_function	toxin activity
B	0001897	biological_process	symbiont-mediated cytolysis of host cell
B	0005576	cellular_component	extracellular region
B	0020002	cellular_component	host cell plasma membrane
B	0035821	biological_process	modulation of process of another organism
B	0042802	molecular_function	identical protein binding
B	0090729	molecular_function	toxin activity
C	0001897	biological_process	symbiont-mediated cytolysis of host cell
C	0005576	cellular_component	extracellular region
C	0020002	cellular_component	host cell plasma membrane
C	0035821	biological_process	modulation of process of another organism
C	0042802	molecular_function	identical protein binding
C	0090729	molecular_function	toxin activity
D	0001897	biological_process	symbiont-mediated cytolysis of host cell
D	0005576	cellular_component	extracellular region
D	0020002	cellular_component	host cell plasma membrane
D	0035821	biological_process	modulation of process of another organism
D	0042802	molecular_function	identical protein binding
D	0090729	molecular_function	toxin activity
E	0001897	biological_process	symbiont-mediated cytolysis of host cell
E	0005576	cellular_component	extracellular region
E	0020002	cellular_component	host cell plasma membrane
E	0035821	biological_process	modulation of process of another organism
E	0042802	molecular_function	identical protein binding
E	0090729	molecular_function	toxin activity
F	0001897	biological_process	symbiont-mediated cytolysis of host cell
F	0005576	cellular_component	extracellular region
F	0020002	cellular_component	host cell plasma membrane
F	0035821	biological_process	modulation of process of another organism
F	0042802	molecular_function	identical protein binding
F	0090729	molecular_function	toxin activity
G	0001897	biological_process	symbiont-mediated cytolysis of host cell
G	0005576	cellular_component	extracellular region
G	0020002	cellular_component	host cell plasma membrane
G	0035821	biological_process	modulation of process of another organism
G	0042802	molecular_function	identical protein binding
G	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS00274
Number of Residues	10
Details	AEROLYSIN Aerolysin type toxins signature. TatNWskTNT

Chain	Residue	Details
A	THR223-THR232

---

site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DGDEVDV

Chain	Residue	Details
A	ASP95-VAL101

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	112
Details	Region: {"description":"Interaction with host N-linked glycan"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	224
Details	Region: {"description":"Part of the transmembrane beta-barrel after proteolytic activation of the toxin and insertion into the host membrane"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	63
Details	Region: {"description":"Interaction with glycans from host GPI-anchor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Site: {"description":"Important for oligomerization"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Site: {"description":"Important for heptamerization"}

Chain

Residue

Details

---