9FML

Aerolysin heptamer in membrane inserted form reconstituted in amphipoles.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001897	biological_process	symbiont-mediated cytolysis of host cell
A	0005576	cellular_component	extracellular region
A	0016020	cellular_component	membrane
A	0020002	cellular_component	host cell plasma membrane
A	0033644	cellular_component	host cell membrane
A	0035821	biological_process	modulation of process of another organism
A	0042802	molecular_function	identical protein binding
A	0090729	molecular_function	toxin activity
B	0001897	biological_process	symbiont-mediated cytolysis of host cell
B	0005576	cellular_component	extracellular region
B	0016020	cellular_component	membrane
B	0020002	cellular_component	host cell plasma membrane
B	0033644	cellular_component	host cell membrane
B	0035821	biological_process	modulation of process of another organism
B	0042802	molecular_function	identical protein binding
B	0090729	molecular_function	toxin activity
C	0001897	biological_process	symbiont-mediated cytolysis of host cell
C	0005576	cellular_component	extracellular region
C	0016020	cellular_component	membrane
C	0020002	cellular_component	host cell plasma membrane
C	0033644	cellular_component	host cell membrane
C	0035821	biological_process	modulation of process of another organism
C	0042802	molecular_function	identical protein binding
C	0090729	molecular_function	toxin activity
D	0001897	biological_process	symbiont-mediated cytolysis of host cell
D	0005576	cellular_component	extracellular region
D	0016020	cellular_component	membrane
D	0020002	cellular_component	host cell plasma membrane
D	0033644	cellular_component	host cell membrane
D	0035821	biological_process	modulation of process of another organism
D	0042802	molecular_function	identical protein binding
D	0090729	molecular_function	toxin activity
E	0001897	biological_process	symbiont-mediated cytolysis of host cell
E	0005576	cellular_component	extracellular region
E	0016020	cellular_component	membrane
E	0020002	cellular_component	host cell plasma membrane
E	0033644	cellular_component	host cell membrane
E	0035821	biological_process	modulation of process of another organism
E	0042802	molecular_function	identical protein binding
E	0090729	molecular_function	toxin activity
F	0001897	biological_process	symbiont-mediated cytolysis of host cell
F	0005576	cellular_component	extracellular region
F	0016020	cellular_component	membrane
F	0020002	cellular_component	host cell plasma membrane
F	0033644	cellular_component	host cell membrane
F	0035821	biological_process	modulation of process of another organism
F	0042802	molecular_function	identical protein binding
F	0090729	molecular_function	toxin activity
G	0001897	biological_process	symbiont-mediated cytolysis of host cell
G	0005576	cellular_component	extracellular region
G	0016020	cellular_component	membrane
G	0020002	cellular_component	host cell plasma membrane
G	0033644	cellular_component	host cell membrane
G	0035821	biological_process	modulation of process of another organism
G	0042802	molecular_function	identical protein binding
G	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS00274
Number of Residues	10
Details	AEROLYSIN Aerolysin type toxins signature. TatNWskTNT

Chain	Residue	Details
A	THR223-THR232

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site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DGDEVDV

Chain	Residue	Details
A	ASP95-VAL101

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	SITE: Important for oligomerization

Chain	Residue	Details
A	HIS132
B	HIS132
C	HIS132
D	HIS132
E	HIS132
F	HIS132
G	HIS132

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site_id	SWS_FT_FI2
Number of Residues	14
Details	SITE: Important for heptamerization

Chain	Residue	Details
A	LYS351
E	GLU367
F	LYS351
F	GLU367
G	LYS351
G	GLU367
A	GLU367
B	LYS351
B	GLU367
C	LYS351
C	GLU367
D	LYS351
D	GLU367
E	LYS351

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