9FL9

Cryo-EM structure of the human KEOPS complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000408	cellular_component	EKC/KEOPS complex
A	0002949	biological_process	tRNA threonylcarbamoyladenosine modification
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0019901	molecular_function	protein kinase binding
A	1990145	biological_process	maintenance of translational fidelity
B	0000408	cellular_component	EKC/KEOPS complex
B	0002039	molecular_function	p53 binding
B	0003824	molecular_function	catalytic activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006468	biological_process	protein phosphorylation
B	0070525	biological_process	tRNA threonylcarbamoyladenosine metabolic process
B	0106310	molecular_function	protein serine kinase activity
B	1901796	biological_process	regulation of signal transduction by p53 class mediator
B	1990145	biological_process	maintenance of translational fidelity
C	0000408	cellular_component	EKC/KEOPS complex
C	0002949	biological_process	tRNA threonylcarbamoyladenosine modification
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006400	biological_process	tRNA modification
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0061711	molecular_function	tRNA N(6)-L-threonylcarbamoyladenine synthase activity
C	1990145	biological_process	maintenance of translational fidelity
D	0000408	cellular_component	EKC/KEOPS complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0016604	cellular_component	nuclear body
D	0070525	biological_process	tRNA threonylcarbamoyladenosine metabolic process
D	1990145	biological_process	maintenance of translational fidelity
E	0000408	cellular_component	EKC/KEOPS complex
E	0002949	biological_process	tRNA threonylcarbamoyladenosine modification
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	1990145	biological_process	maintenance of translational fidelity

Functional Information from PROSITE/UniProt

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LIHgDLTTSNMLL

Chain	Residue	Details
B	LEU158-LEU170

---

site_id	PS01016
Number of Residues	21
Details	GLYCOPROTEASE Glycoprotease family signature. RTvaqlWNkPlVgvnHciGHI

Chain	Residue	Details
C	ARG94-ILE114

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03180","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---