Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9FL7

Cryo-EM structure of human AK2 bound to reduced human AIFM1 (residues 102-613), class 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0046983	molecular_function	protein dimerization activity
B	0016491	molecular_function	oxidoreductase activity
B	0046983	molecular_function	protein dimerization activity
D	0000166	molecular_function	nucleotide binding
D	0004017	molecular_function	AMP kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005758	cellular_component	mitochondrial intermembrane space
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006172	biological_process	ADP biosynthetic process
D	0009117	biological_process	nucleotide metabolic process
D	0009123	biological_process	nucleoside monophosphate metabolic process
D	0015949	biological_process	nucleobase-containing small molecule interconversion
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0016776	molecular_function	phosphotransferase activity, phosphate group as acceptor
D	0019205	molecular_function	nucleobase-containing compound kinase activity
D	0036126	cellular_component	sperm flagellum
D	0046033	biological_process	AMP metabolic process
D	0046034	biological_process	ATP metabolic process
D	0046940	biological_process	nucleoside monophosphate phosphorylation
D	0070062	cellular_component	extracellular exosome
D	0097226	cellular_component	sperm mitochondrial sheath

Functional Information from PROSITE/UniProt

site_id	PS00113
Number of Residues	12
Details	ADENYLATE_KINASE Adenylate kinase signature. FLLDGFPRtvrQ

Chain	Residue	Details
D	PHE96-GLN107

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	698
Details	Region: {"description":"FAD-dependent oxidoreductase","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	10
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23217327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23217327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23217327","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Z0X1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12198487","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27178839","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27818101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FS9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24914854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9Z0X1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22103349","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	29
Details	Region: {"description":"NMP","evidences":[{"source":"HAMAP-Rule","id":"MF_03168","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2006","submissionDatabase":"PDB data bank","title":"Structure of human adenylate kinase 2.","authors":["Bunkoczi G.","Filippakopoulos P.","Debreczeni J.E.","Turnbull A.","Papagrigoriou E.","Savitsky P.","Colebrook S.","Von Delft F.","Arrowsmith C.","Edwards A.","Sundstrom M.","Weigelt J.","Knapp S."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	37
Details	Region: {"description":"LID","evidences":[{"source":"HAMAP-Rule","id":"MF_03168","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2006","submissionDatabase":"PDB data bank","title":"Structure of human adenylate kinase 2.","authors":["Bunkoczi G.","Filippakopoulos P.","Debreczeni J.E.","Turnbull A.","Papagrigoriou E.","Savitsky P.","Colebrook S.","Von Delft F.","Arrowsmith C.","Edwards A.","Sundstrom M.","Weigelt J.","Knapp S."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	19
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	18
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03168","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2006","submissionDatabase":"PDB data bank","title":"Structure of human adenylate kinase 2.","authors":["Bunkoczi G.","Filippakopoulos P.","Debreczeni J.E.","Turnbull A.","Papagrigoriou E.","Savitsky P.","Colebrook S.","Von Delft F.","Arrowsmith C.","Edwards A.","Sundstrom M.","Weigelt J.","Knapp S."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03168","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2006","submissionDatabase":"PDB data bank","title":"Structure of human adenylate kinase 2.","authors":["Bunkoczi G.","Filippakopoulos P.","Debreczeni J.E.","Turnbull A.","Papagrigoriou E.","Savitsky P.","Colebrook S.","Von Delft F.","Arrowsmith C.","Edwards A.","Sundstrom M.","Weigelt J.","Knapp S."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9WTP6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9WTP6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)