9FL3

Crystal structure of IL-17A in complex with compound 26

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002225	biological_process	positive regulation of antimicrobial peptide production
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006915	biological_process	apoptotic process
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response
A	0007219	biological_process	Notch signaling pathway
A	0007267	biological_process	cell-cell signaling
A	0008219	biological_process	cell death
A	0009611	biological_process	response to wounding
A	0009897	cellular_component	external side of plasma membrane
A	0010467	biological_process	gene expression
A	0030216	biological_process	keratinocyte differentiation
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0032735	biological_process	positive regulation of interleukin-12 production
A	0032739	biological_process	positive regulation of interleukin-16 production
A	0032747	biological_process	positive regulation of interleukin-23 production
A	0032755	biological_process	positive regulation of interleukin-6 production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0038173	biological_process	interleukin-17A-mediated signaling pathway
A	0042803	molecular_function	protein homodimerization activity
A	0043616	biological_process	keratinocyte proliferation
A	0045087	biological_process	innate immune response
A	0045672	biological_process	positive regulation of osteoclast differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046982	molecular_function	protein heterodimerization activity
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0050832	biological_process	defense response to fungus
A	0060729	biological_process	intestinal epithelial structure maintenance
A	0070534	biological_process	protein K63-linked ubiquitination
A	0072537	biological_process	fibroblast activation
A	0072538	biological_process	T-helper 17 type immune response
A	0080090	biological_process	regulation of primary metabolic process
A	0097400	biological_process	interleukin-17-mediated signaling pathway
A	0097530	biological_process	granulocyte migration
A	0106015	biological_process	negative regulation of inflammatory response to wounding
A	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
A	1903348	biological_process	positive regulation of bicellular tight junction assembly
A	1903557	biological_process	positive regulation of tumor necrosis factor superfamily cytokine production
A	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production
B	0002225	biological_process	positive regulation of antimicrobial peptide production
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005886	cellular_component	plasma membrane
B	0006915	biological_process	apoptotic process
B	0006954	biological_process	inflammatory response
B	0006955	biological_process	immune response
B	0007219	biological_process	Notch signaling pathway
B	0007267	biological_process	cell-cell signaling
B	0008219	biological_process	cell death
B	0009611	biological_process	response to wounding
B	0009897	cellular_component	external side of plasma membrane
B	0010467	biological_process	gene expression
B	0030216	biological_process	keratinocyte differentiation
B	0032731	biological_process	positive regulation of interleukin-1 beta production
B	0032735	biological_process	positive regulation of interleukin-12 production
B	0032739	biological_process	positive regulation of interleukin-16 production
B	0032747	biological_process	positive regulation of interleukin-23 production
B	0032755	biological_process	positive regulation of interleukin-6 production
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0038173	biological_process	interleukin-17A-mediated signaling pathway
B	0042803	molecular_function	protein homodimerization activity
B	0043616	biological_process	keratinocyte proliferation
B	0045087	biological_process	innate immune response
B	0045672	biological_process	positive regulation of osteoclast differentiation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046982	molecular_function	protein heterodimerization activity
B	0050829	biological_process	defense response to Gram-negative bacterium
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0050832	biological_process	defense response to fungus
B	0060729	biological_process	intestinal epithelial structure maintenance
B	0070534	biological_process	protein K63-linked ubiquitination
B	0072537	biological_process	fibroblast activation
B	0072538	biological_process	T-helper 17 type immune response
B	0080090	biological_process	regulation of primary metabolic process
B	0097400	biological_process	interleukin-17-mediated signaling pathway
B	0097530	biological_process	granulocyte migration
B	0106015	biological_process	negative regulation of inflammatory response to wounding
B	1900017	biological_process	positive regulation of cytokine production involved in inflammatory response
B	1903348	biological_process	positive regulation of bicellular tight junction assembly
B	1903557	biological_process	positive regulation of tumor necrosis factor superfamily cytokine production
B	2000340	biological_process	positive regulation of chemokine (C-X-C motif) ligand 1 production

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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