9FH5

Cryo-EM Structure of Amyloid-beta Fibrils Carrying the Uppsala AbetaUpp(1-42)delta(19-24) Mutation - Polymorph 4

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943

Chain	Residue	Details
A	HIS12
E	HIS20
F	HIS12
F	HIS20
G	HIS12
G	HIS20
H	HIS12
H	HIS20
I	HIS12
I	HIS20
J	HIS12
A	HIS20
J	HIS20
K	HIS12
K	HIS20
L	HIS12
L	HIS20
M	HIS12
M	HIS20
N	HIS12
N	HIS20
O	HIS12
B	HIS12
O	HIS20
P	HIS12
P	HIS20
Q	HIS12
Q	HIS20
R	HIS12
R	HIS20
S	HIS12
S	HIS20
T	HIS12
B	HIS20
T	HIS20
C	HIS12
C	HIS20
D	HIS12
D	HIS20
E	HIS12

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000305|PubMed:10413512, ECO:0000305|PubMed:11274207

Chain	Residue	Details
A	TYR16
J	TYR16
K	TYR16
L	TYR16
M	TYR16
N	TYR16
O	TYR16
P	TYR16
Q	TYR16
R	TYR16
S	TYR16
B	TYR16
T	TYR16
C	TYR16
D	TYR16
E	TYR16
F	TYR16
G	TYR16
H	TYR16
I	TYR16

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:10413512, ECO:0000269|PubMed:11274207, ECO:0000269|PubMed:26898943

Chain	Residue	Details
A	HIS19
J	HIS19
K	HIS19
L	HIS19
M	HIS19
N	HIS19
O	HIS19
P	HIS19
Q	HIS19
R	HIS19
S	HIS19
B	HIS19
T	HIS19
C	HIS19
D	HIS19
E	HIS19
F	HIS19
G	HIS19
H	HIS19
I	HIS19

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	SITE: Cleavage; by caspase-6; when associated with variant 670-N-L-671

Chain	Residue	Details
A	ASP7
J	ASP7
K	ASP7
L	ASP7
M	ASP7
N	ASP7
O	ASP7
P	ASP7
Q	ASP7
R	ASP7
S	ASP7
B	ASP7
T	ASP7
C	ASP7
D	ASP7
E	ASP7
F	ASP7
G	ASP7
H	ASP7
I	ASP7

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	SITE: Cleavage; by ACE => ECO:0000269|PubMed:11604391, ECO:0000269|PubMed:16154999

Chain	Residue	Details
A	ASP13
J	ASP13
K	ASP13
L	ASP13
M	ASP13
N	ASP13
O	ASP13
P	ASP13
Q	ASP13
R	ASP13
S	ASP13
B	ASP13
T	ASP13
C	ASP13
D	ASP13
E	ASP13
F	ASP13
G	ASP13
H	ASP13
I	ASP13

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	SITE: Cleavage; by alpha-secretase => ECO:0000305|PubMed:11851430

Chain	Residue	Details
A	LYS22
J	LYS22
K	LYS22
L	LYS22
M	LYS22
N	LYS22
O	LYS22
P	LYS22
Q	LYS22
R	LYS22
S	LYS22
B	LYS22
T	LYS22
C	LYS22
D	LYS22
E	LYS22
F	LYS22
G	LYS22
H	LYS22
I	LYS22

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	SITE: Cleavage; by theta-secretase => ECO:0000269|PubMed:16816112

Chain	Residue	Details
A	GLY25
J	GLY25
K	GLY25
L	GLY25
M	GLY25
N	GLY25
O	GLY25
P	GLY25
Q	GLY25
R	GLY25
S	GLY25
B	GLY25
T	GLY25
C	GLY25
D	GLY25
E	GLY25
F	GLY25
G	GLY25
H	GLY25
I	GLY25

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	SITE: Implicated in free radical propagation => ECO:0000250

Chain	Residue	Details
A	VAL39
J	VAL39
K	VAL39
L	VAL39
M	VAL39
N	VAL39
O	VAL39
P	VAL39
Q	VAL39
R	VAL39
S	VAL39
B	VAL39
T	VAL39
C	VAL39
D	VAL39
E	VAL39
F	VAL39
G	VAL39
H	VAL39
I	VAL39

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	SITE: Susceptible to oxidation => ECO:0000269|PubMed:10535332

Chain	Residue	Details
A	ILE41
J	ILE41
K	ILE41
L	ILE41
M	ILE41
N	ILE41
O	ILE41
P	ILE41
Q	ILE41
R	ILE41
S	ILE41
B	ILE41
T	ILE41
C	ILE41
D	ILE41
E	ILE41
F	ILE41
G	ILE41
H	ILE41
I	ILE41

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	SITE: Cleavage; by gamma-secretase; site 1 => ECO:0000305|PubMed:11851430

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	20
Details	SITE: Cleavage; by gamma-secretase; site 2 => ECO:0000305|PubMed:11851430

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	20
Details	CARBOHYD: O-linked (HexNAc...) tyrosine; partial => ECO:0000269|PubMed:22576872

Chain	Residue	Details
A	TYR16
J	TYR16
K	TYR16
L	TYR16
M	TYR16
N	TYR16
O	TYR16
P	TYR16
Q	TYR16
R	TYR16
S	TYR16
B	TYR16
T	TYR16
C	TYR16
D	TYR16
E	TYR16
F	TYR16
G	TYR16
H	TYR16
I	TYR16

---