9F6Y

CryoEM structure of Human Mediator subunit MED23 complexed with phosphorylated Elk-1 transcription factor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003713	molecular_function	transcription coactivator activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005667	cellular_component	transcription regulator complex
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0010628	biological_process	positive regulation of gene expression
A	0016592	cellular_component	mediator complex
A	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
A	0051123	biological_process	RNA polymerase II preinitiation complex assembly
A	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
A	0070847	cellular_component	core mediator complex
A	2000409	biological_process	positive regulation of T cell extravasation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by MAPK1 and MAPK8","evidences":[{"source":"PubMed","id":"10637505","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17296730","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7889942","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GlcNAc) threonine","evidences":[{"source":"PubMed","id":"28939839","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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