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9F6C

Cardiac myosin motor domain in the pre-powerstroke state co-crystallized with the inhibitor aficamten

Functional Information from GO Data
ChainGOidnamespacecontents
A0003774molecular_functioncytoskeletal motor activity
A0005524molecular_functionATP binding
A0016459cellular_componentmyosin complex
A0051015molecular_functionactin filament binding
B0003774molecular_functioncytoskeletal motor activity
B0005524molecular_functionATP binding
B0016459cellular_componentmyosin complex
B0051015molecular_functionactin filament binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY178
BGLY178

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6,N6,N6-trimethyllysine => ECO:0000255
ChainResidueDetails
AM3L129
BM3L129

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P02563
ChainResidueDetails
ATHR378
BTHR378

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PDB entries from 2025-06-11

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