Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9F5Y

Structure of the Chlamydomonas reinhardtii respiratory complex I from respiratory supercomplex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0016020	cellular_component	membrane
B	0045271	cellular_component	respiratory chain complex I
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	1902600	biological_process	proton transmembrane transport
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0046872	molecular_function	metal ion binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	1902600	biological_process	proton transmembrane transport
d	0016491	molecular_function	oxidoreductase activity
D	0045271	cellular_component	respiratory chain complex I
D	1902600	biological_process	proton transmembrane transport
e	0005739	cellular_component	mitochondrion
e	0005743	cellular_component	mitochondrial inner membrane
e	0008320	molecular_function	protein transmembrane transporter activity
e	0016020	cellular_component	membrane
e	0016491	molecular_function	oxidoreductase activity
e	0030943	molecular_function	mitochondrion targeting sequence binding
e	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
e	0045039	biological_process	protein insertion into mitochondrial inner membrane
e	0071806	biological_process	protein transmembrane transport
E	0005739	cellular_component	mitochondrion
E	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
E	0016491	molecular_function	oxidoreductase activity
E	0045271	cellular_component	respiratory chain complex I
f	0016020	cellular_component	membrane
f	0016491	molecular_function	oxidoreductase activity
F	0005739	cellular_component	mitochondrion
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0009060	biological_process	aerobic respiration
F	0015990	biological_process	electron transport coupled proton transport
F	0016491	molecular_function	oxidoreductase activity
F	0032981	biological_process	mitochondrial respiratory chain complex I assembly
F	0045271	cellular_component	respiratory chain complex I
F	0046872	molecular_function	metal ion binding
F	0051536	molecular_function	iron-sulfur cluster binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0016020	cellular_component	membrane
g	0016491	molecular_function	oxidoreductase activity
g	0045271	cellular_component	respiratory chain complex I
G	0003954	molecular_function	NADH dehydrogenase activity
G	0005739	cellular_component	mitochondrion
G	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
G	0016491	molecular_function	oxidoreductase activity
G	0032981	biological_process	mitochondrial respiratory chain complex I assembly
G	0045271	cellular_component	respiratory chain complex I
G	0046872	molecular_function	metal ion binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
h	0016020	cellular_component	membrane
h	0016491	molecular_function	oxidoreductase activity
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0005758	cellular_component	mitochondrial intermembrane space
i	0016020	cellular_component	membrane
i	0016491	molecular_function	oxidoreductase activity
i	0032981	biological_process	mitochondrial respiratory chain complex I assembly
i	0045271	cellular_component	respiratory chain complex I
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0022904	biological_process	respiratory electron transport chain
I	0045271	cellular_component	respiratory chain complex I
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0005758	cellular_component	mitochondrial intermembrane space
j	0016020	cellular_component	membrane
j	0016491	molecular_function	oxidoreductase activity
j	0045271	cellular_component	respiratory chain complex I
J	0000035	molecular_function	acyl binding
J	0000036	molecular_function	acyl carrier activity
J	0005739	cellular_component	mitochondrion
J	0006629	biological_process	lipid metabolic process
J	0006631	biological_process	fatty acid metabolic process
J	0006633	biological_process	fatty acid biosynthetic process
J	0016491	molecular_function	oxidoreductase activity
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0016020	cellular_component	membrane
k	0016491	molecular_function	oxidoreductase activity
k	0045271	cellular_component	respiratory chain complex I
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0045271	cellular_component	respiratory chain complex I
l	0016020	cellular_component	membrane
l	0016491	molecular_function	oxidoreductase activity
l	0045271	cellular_component	respiratory chain complex I
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
m	0005739	cellular_component	mitochondrion
m	0005743	cellular_component	mitochondrial inner membrane
m	0016020	cellular_component	membrane
m	0016491	molecular_function	oxidoreductase activity
m	0045271	cellular_component	respiratory chain complex I
M	0005739	cellular_component	mitochondrion
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0016491	molecular_function	oxidoreductase activity
M	0045271	cellular_component	respiratory chain complex I
n	0005739	cellular_component	mitochondrion
n	0045271	cellular_component	respiratory chain complex I
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0045271	cellular_component	respiratory chain complex I
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0016491	molecular_function	oxidoreductase activity
O	0045271	cellular_component	respiratory chain complex I
p	0016491	molecular_function	oxidoreductase activity
P	0005739	cellular_component	mitochondrion
P	0006744	biological_process	ubiquinone biosynthetic process
P	0044877	molecular_function	protein-containing complex binding
q	0016491	molecular_function	oxidoreductase activity
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Q	0016020	cellular_component	membrane
Q	1902600	biological_process	proton transmembrane transport
r	0000035	molecular_function	acyl binding
r	0000036	molecular_function	acyl carrier activity
r	0005739	cellular_component	mitochondrion
r	0006629	biological_process	lipid metabolic process
r	0006631	biological_process	fatty acid metabolic process
r	0006633	biological_process	fatty acid biosynthetic process
r	0016491	molecular_function	oxidoreductase activity
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
R	0016020	cellular_component	membrane
R	1902600	biological_process	proton transmembrane transport
s	0016491	molecular_function	oxidoreductase activity
s	0031966	cellular_component	mitochondrial membrane
s	0045271	cellular_component	respiratory chain complex I
S	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S	0016020	cellular_component	membrane
S	0030964	cellular_component	NADH dehydrogenase complex
S	1902600	biological_process	proton transmembrane transport
t	0031966	cellular_component	mitochondrial membrane
t	0045271	cellular_component	respiratory chain complex I
T	0005739	cellular_component	mitochondrion
T	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
T	0016020	cellular_component	membrane
T	0031966	cellular_component	mitochondrial membrane
T	1902600	biological_process	proton transmembrane transport
u	0031966	cellular_component	mitochondrial membrane
u	0045271	cellular_component	respiratory chain complex I
U	0016020	cellular_component	membrane
U	0030964	cellular_component	NADH dehydrogenase complex
U	0048038	molecular_function	quinone binding
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
V	0016020	cellular_component	membrane
V	1902600	biological_process	proton transmembrane transport
w	0016491	molecular_function	oxidoreductase activity
W	0005739	cellular_component	mitochondrion
W	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
W	0016020	cellular_component	membrane
W	0031966	cellular_component	mitochondrial membrane
W	1902600	biological_process	proton transmembrane transport
Y	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDVVELVMAL

Chain	Residue	Details
J	ASP80-LEU95

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. LAmaIlLLdiMLKVWVgTnllsgM

Chain	Residue	Details
V	LEU444-MET467

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaICP

Chain	Residue	Details
G	CYS132-PRO143
G	CYS171-PRO182

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. LFINSSFVLmM

Chain	Residue	Details
W	LEU34-MET44

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLlEyK

Chain	Residue	Details
E	LEU120-LYS131

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREtwDMFgvffsgHpdlRrIL

Chain	Residue	Details
D	GLU205-LEU226

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYhqrlsiaGnCRmC

Chain	Residue	Details
C	PRO80-CYS97

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
C	CYS147-GLN159

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCVrF

Chain	Residue	Details
C	ARG194-PHE204

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
B	GLY221-SER236

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
B	GLU398-GLY409

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpFwDGLKLGvKE

Chain	Residue	Details
Q	GLY44-GLU59

site_id	PS00668
Number of Residues	12
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLPEAE..LVa.G

Chain	Residue	Details
Q	PRO194-GLY205

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GELGGLSP

Chain	Residue	Details
p	GLY121-PRO128

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DglFTlgemeCMGaCvnAP

Chain	Residue	Details
A	ASP177-PRO195

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRVVPVDVYvPgCPP

Chain	Residue	Details
F	GLY120-PRO136

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	100
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
W	MET1-THR21
V	GLU264-THR284
V	VAL291-GLY310
V	LEU321-GLY341
V	ALA358-LEU378
V	ILE387-LEU407
V	VAL440-GLY460
V	LEU468-LEU488
W	VAL32-LEU52
W	LEU55-ILE75
W	TRP87-MET107
W	LEU129-PHE149
V	LEU135-TYR155
V	VAL175-GLU195
V	LEU198-GLY218
V	THR237-VAL257

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)